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Motion Sickness: Current Knowledge and Recent Advance.
CNS Neurosci Ther. 2016 Jan; 22(1):15-24.CN

Abstract

Motion sickness (MS) is a common physiological response to real or virtual motion. Numerous studies have investigated the neurobiological mechanism and the control measures of MS. This review summarizes the current knowledge about pathogenesis and pathophysiology, prediction, evaluation, and countermeasures of MS. The sensory conflict hypothesis is the most widely accepted theory for MS. Both the hippocampus and vestibular cortex might play a role in forming internal model. The pathophysiology focuses on the visceral afference, thermoregulation and MS-related neuroendocrine. Single-nucleotide polymorphisms (SNPs) in some genes and epigenetic modulation might contribute to MS susceptibility and habituation. Questionnaires, heart rate variability (HRV) and electrogastrogram (EGG) are useful for diagnosing and evaluating MS. We also list MS medications to guide clinical practice. Repeated real motion exposure and combined visual-vestibular interaction training accelerate the progress of habituation. Behavioral and dietary countermeasures, as well as physiotherapy, are also effective in alleviating MS symptoms.

Authors+Show Affiliations

Department of Pharmacology, Second Military Medical University, Shanghai, China.Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China.Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China.Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China.Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China.Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26452639

Citation

Zhang, Li-Li, et al. "Motion Sickness: Current Knowledge and Recent Advance." CNS Neuroscience & Therapeutics, vol. 22, no. 1, 2016, pp. 15-24.
Zhang LL, Wang JQ, Qi RR, et al. Motion Sickness: Current Knowledge and Recent Advance. CNS Neurosci Ther. 2016;22(1):15-24.
Zhang, L. L., Wang, J. Q., Qi, R. R., Pan, L. L., Li, M., & Cai, Y. L. (2016). Motion Sickness: Current Knowledge and Recent Advance. CNS Neuroscience & Therapeutics, 22(1), 15-24. https://doi.org/10.1111/cns.12468
Zhang LL, et al. Motion Sickness: Current Knowledge and Recent Advance. CNS Neurosci Ther. 2016;22(1):15-24. PubMed PMID: 26452639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motion Sickness: Current Knowledge and Recent Advance. AU - Zhang,Li-Li, AU - Wang,Jun-Qin, AU - Qi,Rui-Rui, AU - Pan,Lei-Lei, AU - Li,Min, AU - Cai,Yi-Ling, Y1 - 2015/10/09/ PY - 2015/07/24/received PY - 2015/09/10/revised PY - 2015/09/10/accepted PY - 2015/10/11/entrez PY - 2015/10/11/pubmed PY - 2016/10/19/medline KW - Countermeasure KW - Evaluation KW - Motion sickness KW - Pathogenesis KW - Prediction SP - 15 EP - 24 JF - CNS neuroscience & therapeutics JO - CNS Neurosci Ther VL - 22 IS - 1 N2 - Motion sickness (MS) is a common physiological response to real or virtual motion. Numerous studies have investigated the neurobiological mechanism and the control measures of MS. This review summarizes the current knowledge about pathogenesis and pathophysiology, prediction, evaluation, and countermeasures of MS. The sensory conflict hypothesis is the most widely accepted theory for MS. Both the hippocampus and vestibular cortex might play a role in forming internal model. The pathophysiology focuses on the visceral afference, thermoregulation and MS-related neuroendocrine. Single-nucleotide polymorphisms (SNPs) in some genes and epigenetic modulation might contribute to MS susceptibility and habituation. Questionnaires, heart rate variability (HRV) and electrogastrogram (EGG) are useful for diagnosing and evaluating MS. We also list MS medications to guide clinical practice. Repeated real motion exposure and combined visual-vestibular interaction training accelerate the progress of habituation. Behavioral and dietary countermeasures, as well as physiotherapy, are also effective in alleviating MS symptoms. SN - 1755-5949 UR - https://www.unboundmedicine.com/medline/citation/26452639/full_citation L2 - https://doi.org/10.1111/cns.12468 DB - PRIME DP - Unbound Medicine ER -
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