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A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer.

Abstract

OBJECTIVE

To investigate the effect of Beri-honey-impregnated dressing on diabetic foot ulcer and compare it with normal saline dressing.

STUDY DESIGN

A randomized, controlled trial.

PLACE AND DURATION OF STUDY

Sughra Shafi Medical Complex, Narowal, Pakistan and Bhatti International Trust (BIT) Hospital, Affiliated with Central Park Medical College, Lahore, from February 2006 to February 2010.

METHODOLOGY

Patients with Wagner's grade 1 and 2 ulcers were enrolled. Those patients were divided in two groups; group A (n=179) treated with honey dressing and group B (n=169) treated with normal saline dressing. Outcome measures were calculated in terms of proportion of wounds completely healed (primary outcome), wound healing time, and deterioration of wounds. Patients were followed-up for a maximum of 120 days.

RESULTS

One hundred and thirty six wounds (75.97%) out of 179 were completely healed with honey dressing and 97 (57.39%) out of 169 wtih saline dressing (p=0.001). The median wound healing time was 18.00 (6 - 120) days (Median with IQR) in group A and 29.00 (7 - 120) days (Median with IQR) in group B (p < 0.001).

CONCLUSION

The present results showed that honey is an effective dressing agent instead of conventional dressings, in treating patients of diabetic foot ulcer.

Authors+Show Affiliations

,

Department of General Surgery, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.

,

Department of Microbiology, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.

Department of Biochemistry, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.

Source

MeSH

Adult
Aged
Apitherapy
Bandages
Diabetic Foot
Female
Foot Ulcer
Honey
Humans
Male
Middle Aged
Pakistan
Prospective Studies
Sodium Chloride
Time Factors
Treatment Outcome
Wound Healing

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26454386

Citation

Imran, Muhammad, et al. "A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer." Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 25, no. 10, 2015, pp. 721-5.
Imran M, Hussain MB, Baig M. A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer. J Coll Physicians Surg Pak. 2015;25(10):721-5.
Imran, M., Hussain, M. B., & Baig, M. (2015). A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 25(10), pp. 721-5. doi:10.2015/JCPSP.721725.
Imran M, Hussain MB, Baig M. A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer. J Coll Physicians Surg Pak. 2015;25(10):721-5. PubMed PMID: 26454386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer. AU - Imran,Muhammad, AU - Hussain,Muhammad Barkaat, AU - Baig,Mukhtiar, PY - 2015/02/24/received PY - 2015/08/10/accepted PY - 2015/10/12/entrez PY - 2015/10/12/pubmed PY - 2016/11/1/medline SP - 721 EP - 5 JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JO - J Coll Physicians Surg Pak VL - 25 IS - 10 N2 - OBJECTIVE: To investigate the effect of Beri-honey-impregnated dressing on diabetic foot ulcer and compare it with normal saline dressing. STUDY DESIGN: A randomized, controlled trial. PLACE AND DURATION OF STUDY: Sughra Shafi Medical Complex, Narowal, Pakistan and Bhatti International Trust (BIT) Hospital, Affiliated with Central Park Medical College, Lahore, from February 2006 to February 2010. METHODOLOGY: Patients with Wagner's grade 1 and 2 ulcers were enrolled. Those patients were divided in two groups; group A (n=179) treated with honey dressing and group B (n=169) treated with normal saline dressing. Outcome measures were calculated in terms of proportion of wounds completely healed (primary outcome), wound healing time, and deterioration of wounds. Patients were followed-up for a maximum of 120 days. RESULTS: One hundred and thirty six wounds (75.97%) out of 179 were completely healed with honey dressing and 97 (57.39%) out of 169 wtih saline dressing (p=0.001). The median wound healing time was 18.00 (6 - 120) days (Median with IQR) in group A and 29.00 (7 - 120) days (Median with IQR) in group B (p < 0.001). CONCLUSION: The present results showed that honey is an effective dressing agent instead of conventional dressings, in treating patients of diabetic foot ulcer. SN - 1681-7168 UR - https://www.unboundmedicine.com/medline/citation/26454386/A_Randomized_Controlled_Clinical_Trial_of_Honey_Impregnated_Dressing_for_Treating_Diabetic_Foot_Ulcer_ DB - PRIME DP - Unbound Medicine ER -