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Current and remitted depression and anxiety disorders as risk factors for medication nonadherence.
J Clin Psychiatry. 2015 Sep; 76(9):e1114-21.JC

Abstract

OBJECTIVE

To investigate the impact of current and remitted depression and anxiety disorders and sociodemographic and other related factors on medication nonadherence in a large cohort study.

METHOD

The Medication Adherence Rating Scale was used to assess medication nonadherence of 1,890 medication users in the 4-year follow-up assessment of the Netherlands Study of Depression and Anxiety, which was conducted between 2008 and 2011. Psychiatric diagnoses according to the DSM-IV, sociodemographic and clinical characteristics, and medication use were determined. Medication nonadherence was defined by the tendency to forget a dose, change the dose, stop for a while, skip 1 dose, or take a smaller dosage than prescribed.

RESULTS

Overall medication nonadherence was 44%. In multivariate analyses, all current and remitted depression and anxiety diagnoses were risk factors for medication nonadherence as compared to subjects never having had a depressive or anxiety diagnosis (P < .05). Age (OR = 0.85, P < .001) and antidepressant use (OR = 0.66, P = .001) were associated with less medication nonadherence. Alcohol dependence (OR = 1.67, P = .05) and the number of dietary supplements (OR = 1.18, P = .02) proved risk factors for medication nonadherence. Associations of anxiety diagnosis with medication nonadherence were mainly driven by depression diagnosis.

CONCLUSIONS

All current and remitted depression and anxiety disorders were risk factors for medication nonadherence. Since these disorders are highly comorbid with other medical conditions, health care workers should address medication nonadherence in patients with depression and/or anxiety disorders, even in those who are in symptomatic remission.

Authors+Show Affiliations

Department of Clinical Pharmacology and Pharmacy, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands pm.bet@vumc.nl.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26455675

Citation

Bet, Pierre M., et al. "Current and Remitted Depression and Anxiety Disorders as Risk Factors for Medication Nonadherence." The Journal of Clinical Psychiatry, vol. 76, no. 9, 2015, pp. e1114-21.
Bet PM, Penninx BW, van Laer SD, et al. Current and remitted depression and anxiety disorders as risk factors for medication nonadherence. J Clin Psychiatry. 2015;76(9):e1114-21.
Bet, P. M., Penninx, B. W., van Laer, S. D., Hoogendijk, W. J., & Hugtenburg, J. G. (2015). Current and remitted depression and anxiety disorders as risk factors for medication nonadherence. The Journal of Clinical Psychiatry, 76(9), e1114-21. https://doi.org/10.4088/JCP.14m09001
Bet PM, et al. Current and Remitted Depression and Anxiety Disorders as Risk Factors for Medication Nonadherence. J Clin Psychiatry. 2015;76(9):e1114-21. PubMed PMID: 26455675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current and remitted depression and anxiety disorders as risk factors for medication nonadherence. AU - Bet,Pierre M, AU - Penninx,Brenda W J H, AU - van Laer,Stag D, AU - Hoogendijk,Witte J G, AU - Hugtenburg,Jacqueline G, PY - 2014/01/14/received PY - 2014/10/01/accepted PY - 2015/10/13/entrez PY - 2015/10/13/pubmed PY - 2016/2/9/medline SP - e1114 EP - 21 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 76 IS - 9 N2 - OBJECTIVE: To investigate the impact of current and remitted depression and anxiety disorders and sociodemographic and other related factors on medication nonadherence in a large cohort study. METHOD: The Medication Adherence Rating Scale was used to assess medication nonadherence of 1,890 medication users in the 4-year follow-up assessment of the Netherlands Study of Depression and Anxiety, which was conducted between 2008 and 2011. Psychiatric diagnoses according to the DSM-IV, sociodemographic and clinical characteristics, and medication use were determined. Medication nonadherence was defined by the tendency to forget a dose, change the dose, stop for a while, skip 1 dose, or take a smaller dosage than prescribed. RESULTS: Overall medication nonadherence was 44%. In multivariate analyses, all current and remitted depression and anxiety diagnoses were risk factors for medication nonadherence as compared to subjects never having had a depressive or anxiety diagnosis (P < .05). Age (OR = 0.85, P < .001) and antidepressant use (OR = 0.66, P = .001) were associated with less medication nonadherence. Alcohol dependence (OR = 1.67, P = .05) and the number of dietary supplements (OR = 1.18, P = .02) proved risk factors for medication nonadherence. Associations of anxiety diagnosis with medication nonadherence were mainly driven by depression diagnosis. CONCLUSIONS: All current and remitted depression and anxiety disorders were risk factors for medication nonadherence. Since these disorders are highly comorbid with other medical conditions, health care workers should address medication nonadherence in patients with depression and/or anxiety disorders, even in those who are in symptomatic remission. SN - 1555-2101 UR - https://www.unboundmedicine.com/medline/citation/26455675/Current_and_remitted_depression_and_anxiety_disorders_as_risk_factors_for_medication_nonadherence_ L2 - http://www.psychiatrist.com/jcp/article/pages/2015/v76n09/v76n0904.aspx DB - PRIME DP - Unbound Medicine ER -