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Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease.
J Neural Transm (Vienna) 2016; 123(3):317-21JN

Abstract

Angiotensin-converting enzyme (ACE) has shown altered activity in patients with neurological diseases. An insertion/deletion (I/D) polymorphism of the ACE gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer's disease (AD), and is generally considered to be a disorder primarily affecting memory. We conducted a case-control study in a sample composed of 85 sporadic AD patients and 90 age- and sex-matched controls to investigate the possible effect of the polymorphism and cognitive profile. Our data revealed an association between the ACE polymorphism and AD risk. There was a significant difference in the ACE allele or genotype frequencies between cases and controls. The D/D genotype showed an increased risk for AD and in the amnestic group and the effect was independent on ApoE genotypes.

Authors+Show Affiliations

Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia. achouriafef@yahoo.fr. Biochemistry and Molecular Biology Laboratory, Children's Hospital, Bab Saadoun 1029, Tunis, Tunisia. achouriafef@yahoo.fr.Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.Biochemistry and Molecular Biology Laboratory, Children's Hospital, Bab Saadoun 1029, Tunis, Tunisia.Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.Biochemistry and Molecular Biology Laboratory, Children's Hospital, Bab Saadoun 1029, Tunis, Tunisia.Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.Biochemistry and Molecular Biology Laboratory, Children's Hospital, Bab Saadoun 1029, Tunis, Tunisia.Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26456241

Citation

Achouri-Rassas, Afef, et al. "Association Between ACE Polymorphism, Cognitive Phenotype and APOE E4 Allele in a Tunisian Population With Alzheimer Disease." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 123, no. 3, 2016, pp. 317-21.
Achouri-Rassas A, Ali NB, Cherif A, et al. Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease. J Neural Transm (Vienna). 2016;123(3):317-21.
Achouri-Rassas, A., Ali, N. B., Cherif, A., Fray, S., Siala, H., Zakraoui, N. O., ... Belal, S. (2016). Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease. Journal of Neural Transmission (Vienna, Austria : 1996), 123(3), pp. 317-21. doi:10.1007/s00702-015-1468-3.
Achouri-Rassas A, et al. Association Between ACE Polymorphism, Cognitive Phenotype and APOE E4 Allele in a Tunisian Population With Alzheimer Disease. J Neural Transm (Vienna). 2016;123(3):317-21. PubMed PMID: 26456241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease. AU - Achouri-Rassas,Afef, AU - Ali,Nadia Ben, AU - Cherif,Aroua, AU - Fray,Saloua, AU - Siala,Hajer, AU - Zakraoui,Nouria Oudiaa, AU - Hadj-Fredj,Sondes, AU - Kechaou,Mariem, AU - Anane,Nadia, AU - Echebi,Slim, AU - Messaoud,Taieb, AU - Belal,Samir, Y1 - 2015/10/12/ PY - 2015/06/09/received PY - 2015/10/03/accepted PY - 2015/10/13/entrez PY - 2015/10/13/pubmed PY - 2016/12/15/medline KW - ACE KW - Alzheimer disease KW - Apolipoprotein E KW - Cognitive profile KW - Polymorphism SP - 317 EP - 21 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 123 IS - 3 N2 - Angiotensin-converting enzyme (ACE) has shown altered activity in patients with neurological diseases. An insertion/deletion (I/D) polymorphism of the ACE gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer's disease (AD), and is generally considered to be a disorder primarily affecting memory. We conducted a case-control study in a sample composed of 85 sporadic AD patients and 90 age- and sex-matched controls to investigate the possible effect of the polymorphism and cognitive profile. Our data revealed an association between the ACE polymorphism and AD risk. There was a significant difference in the ACE allele or genotype frequencies between cases and controls. The D/D genotype showed an increased risk for AD and in the amnestic group and the effect was independent on ApoE genotypes. SN - 1435-1463 UR - https://www.unboundmedicine.com/medline/citation/26456241/Association_between_ACE_polymorphism_cognitive_phenotype_and_APOE_E4_allele_in_a_Tunisian_population_with_Alzheimer_disease_ L2 - https://dx.doi.org/10.1007/s00702-015-1468-3 DB - PRIME DP - Unbound Medicine ER -