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Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients.
Korean J Ophthalmol. 2015 Oct; 29(5):285-93.KJ

Abstract

PURPOSE

The incidence and clinical correlation of MALT1 translocation and chromosomal numerical aberrations in Korean patients with ocular adnexal mucosa associated lymphoid tissue (MALT) lymphoma have not yet been reported. We investigated the incidence and clinicopathologic relationship of these chromosomal aberrations in ocular adnexal MALT lymphomas in a Korean population.

METHODS

Thirty ocular adnexal MALT lymphomas were investigated for the t(11;18) API2-MALT1, t(14;18) IgH-MALT1 translocations and chromosomes 3 and 18 aneuploidies using fluorescence in situ hybridization. Patient medical records were reviewed retrospectively for information on demographics and clinical characteristics, including treatment response.

RESULTS

The MALT1 gene rearrangement was found in one out of 30 cases. The t(14;18) IgH-MALT1 translocation was demonstrated in only one case (3.3%), and the t(11;18) API2-MALT1 translocation was not found in any of the cases. Trisomy 3 was observed in three ocular adnexal MALT lymphomas (10.0%), and five cases showed trisomy 18 (16.7%). Translocation positive cases also showed trisomy 18. One case of tumor relapse showed trisomy 18 only in the recurrent biopsies. There were no statistically significant correlations between chromosomal aberrations and clinical characteristics and treatment responses.

CONCLUSIONS

Translocations involving the MALT1 gene are not common in Korean ocular adnexal MALT lymphomas. The t(14;18) translocation was detected in only one out of 30 cases, and the t(11;18) translocation was not found at all. Furthermore, the chromosomal aberrations found in this study had no prognostic implications.

Authors+Show Affiliations

Department of Ophthalmology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.Department of Pathology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.Department of Ophthalmology, Hallym University Sacred Heart Hospital, Anyang, Korea.Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26457033

Citation

Choung, Hokyung, et al. "Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients." Korean Journal of Ophthalmology : KJO, vol. 29, no. 5, 2015, pp. 285-93.
Choung H, Kim YA, Kim N, et al. Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients. Korean J Ophthalmol. 2015;29(5):285-93.
Choung, H., Kim, Y. A., Kim, N., Lee, M. J., & Khwarg, S. I. (2015). Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients. Korean Journal of Ophthalmology : KJO, 29(5), 285-93. https://doi.org/10.3341/kjo.2015.29.5.285
Choung H, et al. Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients. Korean J Ophthalmol. 2015;29(5):285-93. PubMed PMID: 26457033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients. AU - Choung,Hokyung, AU - Kim,Young A, AU - Kim,Namju, AU - Lee,Min Joung, AU - Khwarg,Sang In, Y1 - 2015/09/22/ PY - 2015/01/05/received PY - 2015/03/13/accepted PY - 2015/10/13/entrez PY - 2015/10/13/pubmed PY - 2016/12/15/medline KW - IGH-MALT1 fusion protein, human KW - Lymphoma, B cell, marginal zone KW - Translocation, genetic KW - Trisomy SP - 285 EP - 93 JF - Korean journal of ophthalmology : KJO JO - Korean J Ophthalmol VL - 29 IS - 5 N2 - PURPOSE: The incidence and clinical correlation of MALT1 translocation and chromosomal numerical aberrations in Korean patients with ocular adnexal mucosa associated lymphoid tissue (MALT) lymphoma have not yet been reported. We investigated the incidence and clinicopathologic relationship of these chromosomal aberrations in ocular adnexal MALT lymphomas in a Korean population. METHODS: Thirty ocular adnexal MALT lymphomas were investigated for the t(11;18) API2-MALT1, t(14;18) IgH-MALT1 translocations and chromosomes 3 and 18 aneuploidies using fluorescence in situ hybridization. Patient medical records were reviewed retrospectively for information on demographics and clinical characteristics, including treatment response. RESULTS: The MALT1 gene rearrangement was found in one out of 30 cases. The t(14;18) IgH-MALT1 translocation was demonstrated in only one case (3.3%), and the t(11;18) API2-MALT1 translocation was not found in any of the cases. Trisomy 3 was observed in three ocular adnexal MALT lymphomas (10.0%), and five cases showed trisomy 18 (16.7%). Translocation positive cases also showed trisomy 18. One case of tumor relapse showed trisomy 18 only in the recurrent biopsies. There were no statistically significant correlations between chromosomal aberrations and clinical characteristics and treatment responses. CONCLUSIONS: Translocations involving the MALT1 gene are not common in Korean ocular adnexal MALT lymphomas. The t(14;18) translocation was detected in only one out of 30 cases, and the t(11;18) translocation was not found at all. Furthermore, the chromosomal aberrations found in this study had no prognostic implications. SN - 2092-9382 UR - https://www.unboundmedicine.com/medline/citation/26457033/Clinicopathologic_Study_of_Chromosomal_Aberrations_in_Ocular_Adnexal_Lymphomas_of_Korean_Patients_ L2 - https://ekjo.org/DOIx.php?id=10.3341/kjo.2015.29.5.285 DB - PRIME DP - Unbound Medicine ER -