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Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin.
Phytother Res. 2015 Dec; 29(12):1917-25.PR

Abstract

Camphor ((1R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one), a bicyclic monoterpene, is one of the major constituents of essential oils from various herbs such as rosemary, lavender, and sage. In this study, we investigated the beneficial effects of camphor as a botanical ingredient in cosmetics. Camphor induced the proliferation of human primary dermal fibroblasts in a dose-dependent manner via the PI3K/AKT and ERK signaling pathways. Camphor attenuated the elevation of senescence associated with β-galactosidase (SA-β-gal) activity. Elastase activity decreased, while the total amount of collagen increased, in a dose- and time-dependent manner in human primary dermal fibroblasts treated with camphor. Camphor induced the expression of collagen IA, collagen IIIA, collagen IVA, and elastin in human primary dermal fibroblasts. In addition, posttreatment with 26 and 52 mM camphor for 2 weeks led to a significant reduction in the expression of MMP1 but increases in the expression of collagen IA, IIIA, and elastin in mouse skin exposed to UV for 4 weeks. These posttreatments also reduced the depths of the epidermis and subcutaneous fat layer in UV-exposed mouse skin. Taken together, these findings suggest camphor to be a potent wound healing and antiwrinkle agent with considerable potential for use in cosmeceuticals.

Authors+Show Affiliations

Faculty of Advanced Convergence Technology and Science, Jeju National University, Jeju, Republic of Korea.Department of Biochemistry, School of Medicine, Jeju National University, Jeju, Republic of Korea.Faculty of Biotechnology, College of Applied Life Sciences, SARI, Jeju National University, Jeju, Republic of Korea.Department of Biochemistry, School of Medicine, Jeju National University, Jeju, Republic of Korea.Faculty of Biotechnology, College of Applied Life Sciences, SARI, Jeju National University, Jeju, Republic of Korea. Subtropical Horticulture Research Institute, Jeju National University, Jeju, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26458283

Citation

Tran, Thao Anh, et al. "Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin." Phytotherapy Research : PTR, vol. 29, no. 12, 2015, pp. 1917-25.
Tran TA, Ho MT, Song YW, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015;29(12):1917-25.
Tran, T. A., Ho, M. T., Song, Y. W., Cho, M., & Cho, S. K. (2015). Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytotherapy Research : PTR, 29(12), 1917-25. https://doi.org/10.1002/ptr.5484
Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015;29(12):1917-25. PubMed PMID: 26458283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. AU - Tran,Thao Anh, AU - Ho,Manh Tin, AU - Song,Yeon Woo, AU - Cho,Moonjae, AU - Cho,Somi Kim, Y1 - 2015/10/13/ PY - 2015/03/26/received PY - 2015/08/16/revised PY - 2015/09/15/accepted PY - 2015/10/14/entrez PY - 2015/10/16/pubmed PY - 2016/6/11/medline KW - ERK KW - ROS KW - antiaging KW - camphor KW - dermal fibroblast KW - proliferation SP - 1917 EP - 25 JF - Phytotherapy research : PTR JO - Phytother Res VL - 29 IS - 12 N2 - Camphor ((1R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one), a bicyclic monoterpene, is one of the major constituents of essential oils from various herbs such as rosemary, lavender, and sage. In this study, we investigated the beneficial effects of camphor as a botanical ingredient in cosmetics. Camphor induced the proliferation of human primary dermal fibroblasts in a dose-dependent manner via the PI3K/AKT and ERK signaling pathways. Camphor attenuated the elevation of senescence associated with β-galactosidase (SA-β-gal) activity. Elastase activity decreased, while the total amount of collagen increased, in a dose- and time-dependent manner in human primary dermal fibroblasts treated with camphor. Camphor induced the expression of collagen IA, collagen IIIA, collagen IVA, and elastin in human primary dermal fibroblasts. In addition, posttreatment with 26 and 52 mM camphor for 2 weeks led to a significant reduction in the expression of MMP1 but increases in the expression of collagen IA, IIIA, and elastin in mouse skin exposed to UV for 4 weeks. These posttreatments also reduced the depths of the epidermis and subcutaneous fat layer in UV-exposed mouse skin. Taken together, these findings suggest camphor to be a potent wound healing and antiwrinkle agent with considerable potential for use in cosmeceuticals. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/26458283/Camphor_Induces_Proliferative_and_Anti_senescence_Activities_in_Human_Primary_Dermal_Fibroblasts_and_Inhibits_UV_Induced_Wrinkle_Formation_in_Mouse_Skin_ L2 - https://doi.org/10.1002/ptr.5484 DB - PRIME DP - Unbound Medicine ER -