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High prevalence of vitamin D deficiency among women of child-bearing age in Lahore Pakistan, associating with lack of sun exposure and illiteracy.
BMC Womens Health 2015; 15:83BW

Abstract

BACKGROUND

Vitamin D status is a key determinant of maternal and neonatal health. Deficiency has been reported to be common in Pakistani women, but information regarding environmental and genetic determinants of vitamin D status is lacking in this population.

METHODS

We conducted a cross-sectional study among three groups of healthy women living in Lahore, Pakistan: university students, students or employees of Medrasas or Islamic Institutes, and employees working in office, hospital or domestic settings. Multivariate analysis was performed to identify environmental and genetic determinants of vitamin D status: polymorphisms in genes encoding the vitamin D receptor, vitamin D 25-hydroxylase enzyme CYP2R1 and vitamin D binding protein [DBP] were investigated. We also conducted analyses to identify determinants of body ache and bone pain in this population, and to determine the sensitivity and specificity of testing for hypocalcaemia and raised serum alkaline phosphatase to screen for vitamin D deficiency.

RESULTS

Of 215 participants, 156 (73 %) were vitamin D deficient (serum 25[OH]D <50 nmol/L). Risk of vitamin D deficiency was independently associated with illiteracy (adjusted OR 4.0, 95 % CI 1.03-15.52, P = 0.04), <30 min sun exposure per day (adjusted OR 2.13, 95 % CI 1.08-4.19, P = 0.02), sampling in January to March (adjusted OR 2.38, 95 % CI 1.20-4.70), P = 0.01) and lack of regular intake of multivitamins (adjusted OR 2.61, 95 % CI 1.32-5.16, p = 0.005). Participants with the GG genotype of the rs4588 polymorphism in the gene encoding vitamin D binding protein tended to have lower 25(OH)D concentrations than those with GT/TT genotypes (95 % CI for difference 22.7 to -0.13 nmol/L, P = 0.053). Vitamin D deficiency was independently associated with increased risk of body ache or bone pain (adjusted OR 4.43, 95 % CI 2.07 to 9.49, P = 0.001). Hypocalcaemia (serum calcium concentration ≤9.5 mg/dL) and raised alkaline phosphatase concentration (≥280 IU/L) had low sensitivity and very low specificity for identification of vitamin D deficiency.

CONCLUSION

Vitamin D deficiency is common among healthy women of child-bearing age in Lahore, Pakistan: illiteracy, decreased sun exposure and lack of multivitamin intake are risk factors.

Authors+Show Affiliations

Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore, 5400, Pakistan. kashaf_junaid@hotmail.com.Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore, 5400, Pakistan. rehman_mmg@yahoo.com.Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AB, UK. d.a.jolliffe@qmul.ac.uk.Genome Centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK. kristie.wood@qmul.ac.uk.Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AB, UK. a.martineau@qmul.ac.uk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26458880

Citation

Junaid, Kashaf, et al. "High Prevalence of Vitamin D Deficiency Among Women of Child-bearing Age in Lahore Pakistan, Associating With Lack of Sun Exposure and Illiteracy." BMC Women's Health, vol. 15, 2015, p. 83.
Junaid K, Rehman A, Jolliffe DA, et al. High prevalence of vitamin D deficiency among women of child-bearing age in Lahore Pakistan, associating with lack of sun exposure and illiteracy. BMC Womens Health. 2015;15:83.
Junaid, K., Rehman, A., Jolliffe, D. A., Wood, K., & Martineau, A. R. (2015). High prevalence of vitamin D deficiency among women of child-bearing age in Lahore Pakistan, associating with lack of sun exposure and illiteracy. BMC Women's Health, 15, p. 83. doi:10.1186/s12905-015-0242-x.
Junaid K, et al. High Prevalence of Vitamin D Deficiency Among Women of Child-bearing Age in Lahore Pakistan, Associating With Lack of Sun Exposure and Illiteracy. BMC Womens Health. 2015 Oct 12;15:83. PubMed PMID: 26458880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of vitamin D deficiency among women of child-bearing age in Lahore Pakistan, associating with lack of sun exposure and illiteracy. AU - Junaid,Kashaf, AU - Rehman,Abdul, AU - Jolliffe,David A, AU - Wood,Kristie, AU - Martineau,Adrian R, Y1 - 2015/10/12/ PY - 2015/04/09/received PY - 2015/10/05/accepted PY - 2015/10/14/entrez PY - 2015/10/16/pubmed PY - 2016/7/9/medline SP - 83 EP - 83 JF - BMC women's health JO - BMC Womens Health VL - 15 N2 - BACKGROUND: Vitamin D status is a key determinant of maternal and neonatal health. Deficiency has been reported to be common in Pakistani women, but information regarding environmental and genetic determinants of vitamin D status is lacking in this population. METHODS: We conducted a cross-sectional study among three groups of healthy women living in Lahore, Pakistan: university students, students or employees of Medrasas or Islamic Institutes, and employees working in office, hospital or domestic settings. Multivariate analysis was performed to identify environmental and genetic determinants of vitamin D status: polymorphisms in genes encoding the vitamin D receptor, vitamin D 25-hydroxylase enzyme CYP2R1 and vitamin D binding protein [DBP] were investigated. We also conducted analyses to identify determinants of body ache and bone pain in this population, and to determine the sensitivity and specificity of testing for hypocalcaemia and raised serum alkaline phosphatase to screen for vitamin D deficiency. RESULTS: Of 215 participants, 156 (73 %) were vitamin D deficient (serum 25[OH]D <50 nmol/L). Risk of vitamin D deficiency was independently associated with illiteracy (adjusted OR 4.0, 95 % CI 1.03-15.52, P = 0.04), <30 min sun exposure per day (adjusted OR 2.13, 95 % CI 1.08-4.19, P = 0.02), sampling in January to March (adjusted OR 2.38, 95 % CI 1.20-4.70), P = 0.01) and lack of regular intake of multivitamins (adjusted OR 2.61, 95 % CI 1.32-5.16, p = 0.005). Participants with the GG genotype of the rs4588 polymorphism in the gene encoding vitamin D binding protein tended to have lower 25(OH)D concentrations than those with GT/TT genotypes (95 % CI for difference 22.7 to -0.13 nmol/L, P = 0.053). Vitamin D deficiency was independently associated with increased risk of body ache or bone pain (adjusted OR 4.43, 95 % CI 2.07 to 9.49, P = 0.001). Hypocalcaemia (serum calcium concentration ≤9.5 mg/dL) and raised alkaline phosphatase concentration (≥280 IU/L) had low sensitivity and very low specificity for identification of vitamin D deficiency. CONCLUSION: Vitamin D deficiency is common among healthy women of child-bearing age in Lahore, Pakistan: illiteracy, decreased sun exposure and lack of multivitamin intake are risk factors. SN - 1472-6874 UR - https://www.unboundmedicine.com/medline/citation/26458880/High_prevalence_of_vitamin_D_deficiency_among_women_of_child_bearing_age_in_Lahore_Pakistan_associating_with_lack_of_sun_exposure_and_illiteracy_ L2 - https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-015-0242-x DB - PRIME DP - Unbound Medicine ER -