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Patterns of heart rate variability and cardiac autonomic modulations in controlled and uncontrolled asthmatic patients.
BMC Pulm Med. 2015 Oct 12; 15:119.BP

Abstract

BACKGROUND

Previous heart rate variability (HRV) studies in asthmatic subjects (AS) demonstrate predominance of parasympathetic drive concomitant with low HRV, which is against the general belief that enhanced parasympathetic modulation improves HRV. The aim of this study was to compare patterns of HRV and cardiac autonomic modulations of AS to healthy control subjects (HS).

METHODS

Eighty AS and forty HS were enrolled in the study. Asthma control test and spirometry were used to discriminate uncontrolled (UA) from controlled (CA) asthmatic patients. Natural logarithmic (Ln) scale of total power (TP), very low frequency (VLF), low frequency (LF) and high frequency (HF) were used to evaluate HRV. Normalized low frequency (LF Norm) and high frequency (HF Norm) were used to determine sympathetic and parasympathetic autonomic modulations respectively.

RESULTS

CA patients achieved significantly higher LnTP, LnLF, LnHF and HF Norm but lower LF Norm and LnLF/HF compared with UA patients (p < 0.05). Although CA patients showed increased HRV and augmented vagal modulation compared with HS, these findings were no longer significant following adjustment for mean heart rates and anti-asthma treatment. All measured HRV parameters were not significantly different in UA patients compared with the HS (p > 0.05).

CONCLUSIONS

CA is associated with enhanced parasympathetic modulations and higher HRV compared with UA. However, neither CA nor UA patients had different autonomic modulations and/or HRV compared with HS.

Authors+Show Affiliations

Department of Physiology, Faculty of Medicine and Health Sciences, Al-Neelain University, Khartoum, Sudan. mohamedfaisallutfi@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26459382

Citation

Lutfi, Mohamed Faisal. "Patterns of Heart Rate Variability and Cardiac Autonomic Modulations in Controlled and Uncontrolled Asthmatic Patients." BMC Pulmonary Medicine, vol. 15, 2015, p. 119.
Lutfi MF. Patterns of heart rate variability and cardiac autonomic modulations in controlled and uncontrolled asthmatic patients. BMC Pulm Med. 2015;15:119.
Lutfi, M. F. (2015). Patterns of heart rate variability and cardiac autonomic modulations in controlled and uncontrolled asthmatic patients. BMC Pulmonary Medicine, 15, 119. https://doi.org/10.1186/s12890-015-0118-8
Lutfi MF. Patterns of Heart Rate Variability and Cardiac Autonomic Modulations in Controlled and Uncontrolled Asthmatic Patients. BMC Pulm Med. 2015 Oct 12;15:119. PubMed PMID: 26459382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterns of heart rate variability and cardiac autonomic modulations in controlled and uncontrolled asthmatic patients. A1 - Lutfi,Mohamed Faisal, Y1 - 2015/10/12/ PY - 2015/04/19/received PY - 2015/10/05/accepted PY - 2015/10/14/entrez PY - 2015/10/16/pubmed PY - 2016/6/29/medline SP - 119 EP - 119 JF - BMC pulmonary medicine JO - BMC Pulm Med VL - 15 N2 - BACKGROUND: Previous heart rate variability (HRV) studies in asthmatic subjects (AS) demonstrate predominance of parasympathetic drive concomitant with low HRV, which is against the general belief that enhanced parasympathetic modulation improves HRV. The aim of this study was to compare patterns of HRV and cardiac autonomic modulations of AS to healthy control subjects (HS). METHODS: Eighty AS and forty HS were enrolled in the study. Asthma control test and spirometry were used to discriminate uncontrolled (UA) from controlled (CA) asthmatic patients. Natural logarithmic (Ln) scale of total power (TP), very low frequency (VLF), low frequency (LF) and high frequency (HF) were used to evaluate HRV. Normalized low frequency (LF Norm) and high frequency (HF Norm) were used to determine sympathetic and parasympathetic autonomic modulations respectively. RESULTS: CA patients achieved significantly higher LnTP, LnLF, LnHF and HF Norm but lower LF Norm and LnLF/HF compared with UA patients (p < 0.05). Although CA patients showed increased HRV and augmented vagal modulation compared with HS, these findings were no longer significant following adjustment for mean heart rates and anti-asthma treatment. All measured HRV parameters were not significantly different in UA patients compared with the HS (p > 0.05). CONCLUSIONS: CA is associated with enhanced parasympathetic modulations and higher HRV compared with UA. However, neither CA nor UA patients had different autonomic modulations and/or HRV compared with HS. SN - 1471-2466 UR - https://www.unboundmedicine.com/medline/citation/26459382/Patterns_of_heart_rate_variability_and_cardiac_autonomic_modulations_in_controlled_and_uncontrolled_asthmatic_patients_ L2 - https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-015-0118-8 DB - PRIME DP - Unbound Medicine ER -