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Connective tissue biochemistry of the aging dermis. Age-associated alterations in collagen and elastin.
Clin Geriatr Med. 1989 Feb; 5(1):127-47.CG

Abstract

Cutaneous aging represents a complex situation in which at least two independent factors--innate aging and solar exposure--contribute to the development of degenerative changes in the dermis. The biochemical and ultrastructural evidence reviewed in this article indicates that reduced collagen deposition, as a result of diminished collagen biosynthesis and reduced proliferative capacity of the fibroblasts, could explain the development of dermal atrophy and would relate to poor wound healing in the elderly. At the same time, perturbations in the supramolecular organization of the elastic fiber network lead to alterations in the mechanical properties of the skin, as manifested by loose and sagging skin with reduced resilience and elasticity.

Authors+Show Affiliations

Department of Dermatology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

2645992

Citation

Uitto, J. "Connective Tissue Biochemistry of the Aging Dermis. Age-associated Alterations in Collagen and Elastin." Clinics in Geriatric Medicine, vol. 5, no. 1, 1989, pp. 127-47.
Uitto J. Connective tissue biochemistry of the aging dermis. Age-associated alterations in collagen and elastin. Clin Geriatr Med. 1989;5(1):127-47.
Uitto, J. (1989). Connective tissue biochemistry of the aging dermis. Age-associated alterations in collagen and elastin. Clinics in Geriatric Medicine, 5(1), 127-47.
Uitto J. Connective Tissue Biochemistry of the Aging Dermis. Age-associated Alterations in Collagen and Elastin. Clin Geriatr Med. 1989;5(1):127-47. PubMed PMID: 2645992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Connective tissue biochemistry of the aging dermis. Age-associated alterations in collagen and elastin. A1 - Uitto,J, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 127 EP - 47 JF - Clinics in geriatric medicine JO - Clin Geriatr Med VL - 5 IS - 1 N2 - Cutaneous aging represents a complex situation in which at least two independent factors--innate aging and solar exposure--contribute to the development of degenerative changes in the dermis. The biochemical and ultrastructural evidence reviewed in this article indicates that reduced collagen deposition, as a result of diminished collagen biosynthesis and reduced proliferative capacity of the fibroblasts, could explain the development of dermal atrophy and would relate to poor wound healing in the elderly. At the same time, perturbations in the supramolecular organization of the elastic fiber network lead to alterations in the mechanical properties of the skin, as manifested by loose and sagging skin with reduced resilience and elasticity. SN - 0749-0690 UR - https://www.unboundmedicine.com/medline/citation/2645992/Connective_tissue_biochemistry_of_the_aging_dermis__Age_associated_alterations_in_collagen_and_elastin_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -
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