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Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode.
Anal Sci. 2015; 31(10):961-9.AS

Abstract

Novel, sensitive and rapid electrochemical methods for the determination of phenothiazine and azaphenothiazine derivatives were developed. A boron-doped diamond (BDD) electrode was used for electrochemical oxidation of levomepromazine, promazine and prothipendyl. The electrooxidation of these substances demonstrated reversible peaks of oxidation at the potential range 0.55 - 0.75 V vs. SCE. Examining the influence of scan rate allowed is to demonstrate that the currents registered typical of the diffusion-controlled process. Determinations of the studied analytes were carried out by means of a square wave voltammetry (SWV) method and a differential pulse voltammetry (DPV) method. Linear ranges of determination with the use of the BDD electrode and the SWV method were obtained in the ranges: from 4 × 10(-7) to 1.38 × 10(-4) mol L(-1) for levomepromazine, from 4 × 10(-7) to 1.17 × 10(-5) mol L(-1) for promazine and from 4.95 × 10(-7) to 4.54 × 10(-5) mol L(-1) for prothipendyl. The influence of interferences on the voltammetric signal of the studied analytes was also checked. The proposed procedures were used for quantitative determination of the studied compounds in pharmaceutical preparations. The measurements showed high accuracy. The recovery values obtained ranged from 98.52 to 99.57%. The developed procedures were compared with pharmacopoeial reference methods.

Authors+Show Affiliations

University of Bialystok, Institute of Chemistry.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26460359

Citation

Mielech-Łukasiewicz, Katarzyna, and Elżbieta Staśkowska. "Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode." Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry, vol. 31, no. 10, 2015, pp. 961-9.
Mielech-Łukasiewicz K, Staśkowska E. Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode. Anal Sci. 2015;31(10):961-9.
Mielech-Łukasiewicz, K., & Staśkowska, E. (2015). Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode. Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry, 31(10), 961-9. https://doi.org/10.2116/analsci.31.961
Mielech-Łukasiewicz K, Staśkowska E. Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode. Anal Sci. 2015;31(10):961-9. PubMed PMID: 26460359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode. AU - Mielech-Łukasiewicz,Katarzyna, AU - Staśkowska,Elżbieta, PY - 2015/10/14/entrez PY - 2015/10/16/pubmed PY - 2016/7/21/medline SP - 961 EP - 9 JF - Analytical sciences : the international journal of the Japan Society for Analytical Chemistry JO - Anal Sci VL - 31 IS - 10 N2 - Novel, sensitive and rapid electrochemical methods for the determination of phenothiazine and azaphenothiazine derivatives were developed. A boron-doped diamond (BDD) electrode was used for electrochemical oxidation of levomepromazine, promazine and prothipendyl. The electrooxidation of these substances demonstrated reversible peaks of oxidation at the potential range 0.55 - 0.75 V vs. SCE. Examining the influence of scan rate allowed is to demonstrate that the currents registered typical of the diffusion-controlled process. Determinations of the studied analytes were carried out by means of a square wave voltammetry (SWV) method and a differential pulse voltammetry (DPV) method. Linear ranges of determination with the use of the BDD electrode and the SWV method were obtained in the ranges: from 4 × 10(-7) to 1.38 × 10(-4) mol L(-1) for levomepromazine, from 4 × 10(-7) to 1.17 × 10(-5) mol L(-1) for promazine and from 4.95 × 10(-7) to 4.54 × 10(-5) mol L(-1) for prothipendyl. The influence of interferences on the voltammetric signal of the studied analytes was also checked. The proposed procedures were used for quantitative determination of the studied compounds in pharmaceutical preparations. The measurements showed high accuracy. The recovery values obtained ranged from 98.52 to 99.57%. The developed procedures were compared with pharmacopoeial reference methods. SN - 1348-2246 UR - https://www.unboundmedicine.com/medline/citation/26460359/Sensitive_and_Rapid_Voltammetric_Determination_of_Phenothiazine_and_Azaphenothiazine_Derivatives_in_Pharmaceuticals_Using_a_Boron_doped_Diamond_Electrode_ L2 - https://dx.doi.org/10.2116/analsci.31.961 DB - PRIME DP - Unbound Medicine ER -