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Evolution of the Die-Wall Pressure during the Compression of Biconvex Tablets: Experimental Results and Comparison with FEM Simulation.
J Pharm Sci. 2015 Dec; 104(12):4339-4344.JP

Abstract

Capping is a classical manufacturing problem for tablets, which is known to affect more biconvex tablets than flat-faced ones. One reason could be the development of a higher residual die-wall pressure during unloading. Unfortunately, contradictory results were published on the subject. In this work, the evolution of the die-wall pressure during the compaction of biconvex tablets was studied experimentally and using finite element method (FEM) modeling. It was compared with the case of flat-faced tablets. Experimental and numerical results showed that during the compression of biconvex tablet, a lower maximum die-wall pressure and a higher residual die-wall pressure were obtained compared with the case of flat-faced tablet. Moreover, both approaches showed, for biconvex tablets, a temporary increase of the die-wall pressure at the end of the unloading phase. FEM demonstrated that this phenomenon was due to a gradual loss of contact between the punch and the tablet from the side to the center. This complex unloading behavior causes the temporary increase of the die-wall pressure and the development of a shear stress between the convex part and the land of the tablet. This could explain the capping tendency of biconvex tablets.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mazel V
Univ. Bordeaux, CNRS, Bordeaux INP, ENSAM, Bordeaux F-33000, France.
Diarra H
CNRS, Univ. Bordeaux, Bordeaux INP, ENSAM, Bordeaux F-33000, France.
Busignies V
Univ. Bordeaux, CNRS, Bordeaux INP, ENSAM, Bordeaux F-33000, France. Electronic address: vincent.mazel@u-bordeaux.fr.
Tchoreloff P
Univ. Bordeaux, CNRS, Bordeaux INP, ENSAM, Bordeaux F-33000, France.

MeSH

ExcipientsFinite Element AnalysisPowdersPressureStress, MechanicalTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26460539

Citation

Mazel, Vincent, et al. "Evolution of the Die-Wall Pressure During the Compression of Biconvex Tablets: Experimental Results and Comparison With FEM Simulation." Journal of Pharmaceutical Sciences, vol. 104, no. 12, 2015, pp. 4339-4344.
Mazel V, Diarra H, Busignies V, et al. Evolution of the Die-Wall Pressure during the Compression of Biconvex Tablets: Experimental Results and Comparison with FEM Simulation. J Pharm Sci. 2015;104(12):4339-4344.
Mazel, V., Diarra, H., Busignies, V., & Tchoreloff, P. (2015). Evolution of the Die-Wall Pressure during the Compression of Biconvex Tablets: Experimental Results and Comparison with FEM Simulation. Journal of Pharmaceutical Sciences, 104(12), 4339-4344. https://doi.org/10.1002/jps.24682
Mazel V, et al. Evolution of the Die-Wall Pressure During the Compression of Biconvex Tablets: Experimental Results and Comparison With FEM Simulation. J Pharm Sci. 2015;104(12):4339-4344. PubMed PMID: 26460539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evolution of the Die-Wall Pressure during the Compression of Biconvex Tablets: Experimental Results and Comparison with FEM Simulation. AU - Mazel,Vincent, AU - Diarra,Harona, AU - Busignies,Virginie, AU - Tchoreloff,Pierre, Y1 - 2015/10/13/ PY - 2015/05/29/received PY - 2015/09/15/revised PY - 2015/09/17/accepted PY - 2015/10/14/entrez PY - 2015/10/16/pubmed PY - 2016/10/1/medline KW - compression KW - excipients KW - powder technology KW - tablet KW - tableting SP - 4339 EP - 4344 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 104 IS - 12 N2 - Capping is a classical manufacturing problem for tablets, which is known to affect more biconvex tablets than flat-faced ones. One reason could be the development of a higher residual die-wall pressure during unloading. Unfortunately, contradictory results were published on the subject. In this work, the evolution of the die-wall pressure during the compaction of biconvex tablets was studied experimentally and using finite element method (FEM) modeling. It was compared with the case of flat-faced tablets. Experimental and numerical results showed that during the compression of biconvex tablet, a lower maximum die-wall pressure and a higher residual die-wall pressure were obtained compared with the case of flat-faced tablet. Moreover, both approaches showed, for biconvex tablets, a temporary increase of the die-wall pressure at the end of the unloading phase. FEM demonstrated that this phenomenon was due to a gradual loss of contact between the punch and the tablet from the side to the center. This complex unloading behavior causes the temporary increase of the die-wall pressure and the development of a shear stress between the convex part and the land of the tablet. This could explain the capping tendency of biconvex tablets. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/26460539/Evolution_of_the_Die_Wall_Pressure_during_the_Compression_of_Biconvex_Tablets:_Experimental_Results_and_Comparison_with_FEM_Simulation_ DB - PRIME DP - Unbound Medicine ER -