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Dietary fatty acids intake and endometrial cancer risk: a dose-response meta-analysis of epidemiological studies.
Oncotarget. 2015 Nov 03; 6(34):36081-97.O

Abstract

Epidemiological studies have provided controversial evidence of the association between dietary fatty acids intake and endometrial cancer risk. The continuous update project of World Cancer Research Fund failed to focus on this issue. To address this inconsistency, we conducted this dose-response meta-analysis based on epidemiological studies published up to the end of June 2015 identified from PubMed, EMBASE and Web of Science. Two authors independently performed the eligibility evaluation and data extraction. Random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Fourteen epidemiological studies (4 cohort and 10 case-control studies) were included in this dose-response meta-analysis. The summary RR for an intake increment of 10g/day was 1.02 (95% CI = 0.97-1.08; I2 = 66.0%) for saturated fatty acids, 0.98 (95% CI = 0.96-1.001; I2 = 0%) for monounsaturated fatty acids, and 1.00 (95% CI = 0.95-1.06; I2 = 0%) for polyunsaturated fatty acids intake. Non-significant results were observed in the majority of subgroup analyses stratified by study characteristics and adjustment for potential confounders in analyses of aforementioned associations. In conclusion, results from this dose-response meta-analysis provided limited evidence that dietary saturated, monounsaturated, and polyunsaturated fatty acids consumption was associated with endometrial cancer risk. Further studies, especial prospective designed or pooled studies are warranted to confirm our findings.

Authors+Show Affiliations

Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26462150

Citation

Wu, Qi-Jun, et al. "Dietary Fatty Acids Intake and Endometrial Cancer Risk: a Dose-response Meta-analysis of Epidemiological Studies." Oncotarget, vol. 6, no. 34, 2015, pp. 36081-97.
Wu QJ, Gong TT, Wang YZ. Dietary fatty acids intake and endometrial cancer risk: a dose-response meta-analysis of epidemiological studies. Oncotarget. 2015;6(34):36081-97.
Wu, Q. J., Gong, T. T., & Wang, Y. Z. (2015). Dietary fatty acids intake and endometrial cancer risk: a dose-response meta-analysis of epidemiological studies. Oncotarget, 6(34), 36081-97. https://doi.org/10.18632/oncotarget.5555
Wu QJ, Gong TT, Wang YZ. Dietary Fatty Acids Intake and Endometrial Cancer Risk: a Dose-response Meta-analysis of Epidemiological Studies. Oncotarget. 2015 Nov 3;6(34):36081-97. PubMed PMID: 26462150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fatty acids intake and endometrial cancer risk: a dose-response meta-analysis of epidemiological studies. AU - Wu,Qi-Jun, AU - Gong,Ting-Ting, AU - Wang,Ya-Zhu, PY - 2015/07/30/received PY - 2015/09/25/accepted PY - 2015/10/14/entrez PY - 2015/10/16/pubmed PY - 2016/10/27/medline KW - endometrial cancer KW - epidemiology KW - fatty acids KW - meta-analysis SP - 36081 EP - 97 JF - Oncotarget JO - Oncotarget VL - 6 IS - 34 N2 - Epidemiological studies have provided controversial evidence of the association between dietary fatty acids intake and endometrial cancer risk. The continuous update project of World Cancer Research Fund failed to focus on this issue. To address this inconsistency, we conducted this dose-response meta-analysis based on epidemiological studies published up to the end of June 2015 identified from PubMed, EMBASE and Web of Science. Two authors independently performed the eligibility evaluation and data extraction. Random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Fourteen epidemiological studies (4 cohort and 10 case-control studies) were included in this dose-response meta-analysis. The summary RR for an intake increment of 10g/day was 1.02 (95% CI = 0.97-1.08; I2 = 66.0%) for saturated fatty acids, 0.98 (95% CI = 0.96-1.001; I2 = 0%) for monounsaturated fatty acids, and 1.00 (95% CI = 0.95-1.06; I2 = 0%) for polyunsaturated fatty acids intake. Non-significant results were observed in the majority of subgroup analyses stratified by study characteristics and adjustment for potential confounders in analyses of aforementioned associations. In conclusion, results from this dose-response meta-analysis provided limited evidence that dietary saturated, monounsaturated, and polyunsaturated fatty acids consumption was associated with endometrial cancer risk. Further studies, especial prospective designed or pooled studies are warranted to confirm our findings. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/26462150/Dietary_fatty_acids_intake_and_endometrial_cancer_risk:_a_dose_response_meta_analysis_of_epidemiological_studies_ L2 - http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=5555 DB - PRIME DP - Unbound Medicine ER -