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Different glucose tolerance status and incident cardiovascular disease and all-cause mortality among elderly Iranians.
Geriatr Gerontol Int. 2016 Dec; 16(12):1263-1271.GG

Abstract

AIMS

To determine the effect of different glucose categories on incident cardiovascular disease (CVD) and all-cause mortality in a population-based cohort.

METHODS

A total of 834 individuals aged 65 years and older without a history of CVD at baseline were stratified according to 2-h post-load glucose fasting glucose test into six categories including: (i) normal fasting glucose/normal glucose tolerance; (ii) prediabetes, (iii) isolated fasting hyperglycemia (IFH); (iv) isolated post-challenge hyperglycemia (IPH); (v) IPH and IFH; and (vi) known diabetes mellitus. The prognostic significance of these groups on CVD and total mortality were examined by Cox proportional hazard ratios in a multivariate adjusted model.

RESULTS

Over 9 years of follow up, 186 incidents of CVD and 218 deaths occurred (72 CVD mortality).Of the population, 45.2%, 30.7%, 1.2%, 6.1% 4.7%, and 11.9% were normal fasting glucose/normal glucose tolerance, prediabetes IFH, IPH, IFH and IPH, and known diabetes mellitus, respectively. Multivariate adjusted hazard ratios for CVD were 1.13 (95% CI 0.78-1.64), 1.03 (95% CI 0.25-4.22), 1.17 (95% CI 0.65-2.11), 2.52 (95% CI 1.43-4.42) and 2.39 (95% CI 1.55-3.69), and for CVD mortality were 0.59 (95% CI 0.27-1.30), 2.02 (95% CI 0.27-15.15), 1.26 (95% CI 0.51-3.16), 3.57 (95% CI 1.64-7.75), and 4.70 (95% CI 2.54-8.69) for prediabetes, IFH, IPH, IFH and IPH, and known diabetes mellitus phenotypes, respectively. Corresponding hazard ratios for all-cause mortality in multivariate model adjusted for prevalent CVD were 1.07 (95% CI 0.73-1.57), 0.59 (95% CI 0.08-4.30), 0.92 (95% CI 0.5-1.70), 2.31 (95% CI 1.33-4.01) and 3.88 (95% CI 2.70-5.55), respectively.

CONCLUSION

Among the elderly population with newly diagnosed diabetes, only the combined IFH and IPH phenotype, but not IFH or IPH alone, was a significant predictor of CVD and mortality events. Prediabetes was not associated with any risk. Geriatr Gerontol Int 2016; 16: 1263-1271.

Authors+Show Affiliations

Prevention of Metabolic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Prevention of Metabolic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Prevention of Metabolic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Prevention of Metabolic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Prevention of Metabolic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26463623

Citation

Mirbolouk, Mohammadhassan, et al. "Different Glucose Tolerance Status and Incident Cardiovascular Disease and All-cause Mortality Among Elderly Iranians." Geriatrics & Gerontology International, vol. 16, no. 12, 2016, pp. 1263-1271.
Mirbolouk M, Hajebrahimi MA, Akbarpour S, et al. Different glucose tolerance status and incident cardiovascular disease and all-cause mortality among elderly Iranians. Geriatr Gerontol Int. 2016;16(12):1263-1271.
Mirbolouk, M., Hajebrahimi, M. A., Akbarpour, S., Tohidi, M., Azizi, F., & Hadaegh, F. (2016). Different glucose tolerance status and incident cardiovascular disease and all-cause mortality among elderly Iranians. Geriatrics & Gerontology International, 16(12), 1263-1271. https://doi.org/10.1111/ggi.12633
Mirbolouk M, et al. Different Glucose Tolerance Status and Incident Cardiovascular Disease and All-cause Mortality Among Elderly Iranians. Geriatr Gerontol Int. 2016;16(12):1263-1271. PubMed PMID: 26463623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different glucose tolerance status and incident cardiovascular disease and all-cause mortality among elderly Iranians. AU - Mirbolouk,Mohammadhassan, AU - Hajebrahimi,Mohammad Ali, AU - Akbarpour,Samaneh, AU - Tohidi,Maryam, AU - Azizi,Fereidoun, AU - Hadaegh,Farzad, Y1 - 2015/10/13/ PY - 2015/08/12/accepted PY - 2015/10/16/pubmed PY - 2018/3/27/medline PY - 2015/10/15/entrez KW - aged KW - cardiovascular disease KW - prediabetes KW - type 2 diabetes SP - 1263 EP - 1271 JF - Geriatrics & gerontology international JO - Geriatr Gerontol Int VL - 16 IS - 12 N2 - AIMS: To determine the effect of different glucose categories on incident cardiovascular disease (CVD) and all-cause mortality in a population-based cohort. METHODS: A total of 834 individuals aged 65 years and older without a history of CVD at baseline were stratified according to 2-h post-load glucose fasting glucose test into six categories including: (i) normal fasting glucose/normal glucose tolerance; (ii) prediabetes, (iii) isolated fasting hyperglycemia (IFH); (iv) isolated post-challenge hyperglycemia (IPH); (v) IPH and IFH; and (vi) known diabetes mellitus. The prognostic significance of these groups on CVD and total mortality were examined by Cox proportional hazard ratios in a multivariate adjusted model. RESULTS: Over 9 years of follow up, 186 incidents of CVD and 218 deaths occurred (72 CVD mortality).Of the population, 45.2%, 30.7%, 1.2%, 6.1% 4.7%, and 11.9% were normal fasting glucose/normal glucose tolerance, prediabetes IFH, IPH, IFH and IPH, and known diabetes mellitus, respectively. Multivariate adjusted hazard ratios for CVD were 1.13 (95% CI 0.78-1.64), 1.03 (95% CI 0.25-4.22), 1.17 (95% CI 0.65-2.11), 2.52 (95% CI 1.43-4.42) and 2.39 (95% CI 1.55-3.69), and for CVD mortality were 0.59 (95% CI 0.27-1.30), 2.02 (95% CI 0.27-15.15), 1.26 (95% CI 0.51-3.16), 3.57 (95% CI 1.64-7.75), and 4.70 (95% CI 2.54-8.69) for prediabetes, IFH, IPH, IFH and IPH, and known diabetes mellitus phenotypes, respectively. Corresponding hazard ratios for all-cause mortality in multivariate model adjusted for prevalent CVD were 1.07 (95% CI 0.73-1.57), 0.59 (95% CI 0.08-4.30), 0.92 (95% CI 0.5-1.70), 2.31 (95% CI 1.33-4.01) and 3.88 (95% CI 2.70-5.55), respectively. CONCLUSION: Among the elderly population with newly diagnosed diabetes, only the combined IFH and IPH phenotype, but not IFH or IPH alone, was a significant predictor of CVD and mortality events. Prediabetes was not associated with any risk. Geriatr Gerontol Int 2016; 16: 1263-1271. SN - 1447-0594 UR - https://www.unboundmedicine.com/medline/citation/26463623/Different_glucose_tolerance_status_and_incident_cardiovascular_disease_and_all_cause_mortality_among_elderly_Iranians_ L2 - https://doi.org/10.1111/ggi.12633 DB - PRIME DP - Unbound Medicine ER -