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Visual Outcomes After Cataract Surgery: Multifocal Versus Monofocal Intraocular Lenses.
J Refract Surg. 2015 Oct; 31(10):658-66.JR

Abstract

PURPOSE

To evaluate visual outcomes, spectacle independence, and quality of life among nonastigmatic and astigmatic patients who received AcrySof IQ ReSTOR toric or nontoric multifocal intraocular lenses (IOLs) (Alcon Laboratories, Fort Worth, TX) compared with those who received commercially available nontoric monofocal IOLs after bilateral cataract removal.

METHODS

This randomized, patient- and observer-technician-masked study was conducted at 20 sites in Europe. Patients were randomized to receive monofocal (nontoric only) or multifocal (nontoric or toric, as needed) IOLs. Primary efficacy endpoints included percentage of patients achieving binocular uncorrected distance and near acuity of 0.1 logMAR or better (20/25 Snellen), spectacle independence, and scores on the National Eye Institute Refractive Error and Quality of Life questionnaire domains. Safety endpoints included adverse events and refractive error within 0.5 and 1.0 diopters.

RESULTS

In the multifocal group (n = 108) versus the monofocal group (n = 100), significantly more patients achieved uncorrected distance and near acuity of 0.1 logMAR or better (45.7% vs 2.1%; P < .0001) and spectacle independence (73.3% vs 25.3%; P < .0001) at 6 months. The percentage of patients who achieved uncorrected distance visual acuity of 20/40 or better at 6 months was 92% in the multifocal group and 97% in the monofocal group. National Eye Institute Refractive Error and Quality of Life scores were significantly better for dependence on correction in the multifocal group (P < .0001) and for glare in the monofocal group (P = .0157); other domain scores were similar between groups. No significant trends in study device-related adverse events were observed.

CONCLUSIONS

Monofocal and multifocal IOLs provided good clinical outcomes. More patients receiving multifocal IOLs attained better uncorrected visual acuity at a range of distances and spectacle independence compared with patients who received monofocal IOLs. Monofocal IOLs were associated with better patient-reported scores for glare compared with multifocal IOLs; however, scores for patient satisfaction were significantly better in the multifocal group.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase IV
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26465253

Citation

Shah, Sunil, et al. "Visual Outcomes After Cataract Surgery: Multifocal Versus Monofocal Intraocular Lenses." Journal of Refractive Surgery (Thorofare, N.J. : 1995), vol. 31, no. 10, 2015, pp. 658-66.
Shah S, Peris-Martinez C, Reinhard T, et al. Visual Outcomes After Cataract Surgery: Multifocal Versus Monofocal Intraocular Lenses. J Refract Surg. 2015;31(10):658-66.
Shah, S., Peris-Martinez, C., Reinhard, T., & Vinciguerra, P. (2015). Visual Outcomes After Cataract Surgery: Multifocal Versus Monofocal Intraocular Lenses. Journal of Refractive Surgery (Thorofare, N.J. : 1995), 31(10), 658-66. https://doi.org/10.3928/1081597X-20150611-01
Shah S, et al. Visual Outcomes After Cataract Surgery: Multifocal Versus Monofocal Intraocular Lenses. J Refract Surg. 2015;31(10):658-66. PubMed PMID: 26465253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visual Outcomes After Cataract Surgery: Multifocal Versus Monofocal Intraocular Lenses. AU - Shah,Sunil, AU - Peris-Martinez,Cristina, AU - Reinhard,Thomas, AU - Vinciguerra,Paolo, PY - 2015/01/29/received PY - 2015/06/08/accepted PY - 2015/10/15/entrez PY - 2015/10/16/pubmed PY - 2016/7/2/medline SP - 658 EP - 66 JF - Journal of refractive surgery (Thorofare, N.J. : 1995) JO - J Refract Surg VL - 31 IS - 10 N2 - PURPOSE: To evaluate visual outcomes, spectacle independence, and quality of life among nonastigmatic and astigmatic patients who received AcrySof IQ ReSTOR toric or nontoric multifocal intraocular lenses (IOLs) (Alcon Laboratories, Fort Worth, TX) compared with those who received commercially available nontoric monofocal IOLs after bilateral cataract removal. METHODS: This randomized, patient- and observer-technician-masked study was conducted at 20 sites in Europe. Patients were randomized to receive monofocal (nontoric only) or multifocal (nontoric or toric, as needed) IOLs. Primary efficacy endpoints included percentage of patients achieving binocular uncorrected distance and near acuity of 0.1 logMAR or better (20/25 Snellen), spectacle independence, and scores on the National Eye Institute Refractive Error and Quality of Life questionnaire domains. Safety endpoints included adverse events and refractive error within 0.5 and 1.0 diopters. RESULTS: In the multifocal group (n = 108) versus the monofocal group (n = 100), significantly more patients achieved uncorrected distance and near acuity of 0.1 logMAR or better (45.7% vs 2.1%; P < .0001) and spectacle independence (73.3% vs 25.3%; P < .0001) at 6 months. The percentage of patients who achieved uncorrected distance visual acuity of 20/40 or better at 6 months was 92% in the multifocal group and 97% in the monofocal group. National Eye Institute Refractive Error and Quality of Life scores were significantly better for dependence on correction in the multifocal group (P < .0001) and for glare in the monofocal group (P = .0157); other domain scores were similar between groups. No significant trends in study device-related adverse events were observed. CONCLUSIONS: Monofocal and multifocal IOLs provided good clinical outcomes. More patients receiving multifocal IOLs attained better uncorrected visual acuity at a range of distances and spectacle independence compared with patients who received monofocal IOLs. Monofocal IOLs were associated with better patient-reported scores for glare compared with multifocal IOLs; however, scores for patient satisfaction were significantly better in the multifocal group. SN - 1081-597X UR - https://www.unboundmedicine.com/medline/citation/26465253/Visual_Outcomes_After_Cataract_Surgery:_Multifocal_Versus_Monofocal_Intraocular_Lenses_ L2 - https://www.healio.com/doiresolver?doi=10.3928/1081597X-20150611-01 DB - PRIME DP - Unbound Medicine ER -