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Use of statins and the incidence of type 2 diabetes mellitus.
Rev Assoc Med Bras (1992) 2015; 61(4):375-80RA

Abstract

INTRODUCTION

the use of statins is associated with reduced cardiovascular risk in studies of primary and secondary prevention, and the reduction is directly proportional to the reduction of LDL-cholesterol. Recent evidence suggests that statins may be associated with a higher incidence of new cases of diabetes. The aim of this review is to explore this possibility, identifying factors associated with the increase in risk and the potential diabetogenic mechanisms of statins. In addition, we evaluated if the risk of diabetes interferes with the reduction in cardiovascular risk achieved with statins.

METHODS

we reviewed articles published in the Scielo and Pubmed databases, which assessed or described the association between use of statins and risk of diabetes up to June 2015.

RESULTS

use of statins is associated with a small increase in the incidence of new cases of diabetes. Age, potency of statin therapy, presence of metabolic syndrome, impaired fasting blood glucose, overweight and previously altered glycated hemoglobin levels are associated with increased risk of diabetes, but there is no consensus about the possible diabetogenic mechanisms of statins. In patients candidate to hypolipemiant drug therapy, the benefit of reducing cardiovascular risk outweighs any risk increase in the incidence of diabetes.

CONCLUSION

statins are associated with a small increase in incidence of diabetes in patients predisposed to glycemic alteration. However, since the benefit of cardiovascular risk reduction prevails even in this group, there is no evidence to date that this finding should change the recommendation of starting statin therapy.

Authors+Show Affiliations

Centro de Epidemiologia e Pesquisa Clínica, Escola de Medicina, Pontifícia Universidade Católica do Paraná, Curitiba, PR, BR.Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, BR.Centro de Epidemiologia e Pesquisa Clínica, Escola de Medicina, Pontifícia Universidade Católica do Paraná, Curitiba, PR, BR.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26466221

Citation

Bernardi, André, et al. "Use of Statins and the Incidence of Type 2 Diabetes Mellitus." Revista Da Associacao Medica Brasileira (1992), vol. 61, no. 4, 2015, pp. 375-80.
Bernardi A, Rocha VZ, Faria-Neto JR. Use of statins and the incidence of type 2 diabetes mellitus. Rev Assoc Med Bras (1992). 2015;61(4):375-80.
Bernardi, A., Rocha, V. Z., & Faria-Neto, J. R. (2015). Use of statins and the incidence of type 2 diabetes mellitus. Revista Da Associacao Medica Brasileira (1992), 61(4), pp. 375-80. doi:10.1590/1806-9282.61.04.375.
Bernardi A, Rocha VZ, Faria-Neto JR. Use of Statins and the Incidence of Type 2 Diabetes Mellitus. Rev Assoc Med Bras (1992). 2015;61(4):375-80. PubMed PMID: 26466221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of statins and the incidence of type 2 diabetes mellitus. AU - Bernardi,André, AU - Rocha,Viviane Zorzanelli, AU - Faria-Neto,José Rocha, PY - 2015/07/15/received PY - 2015/07/16/accepted PY - 2015/10/15/entrez PY - 2015/10/16/pubmed PY - 2016/3/18/medline SP - 375 EP - 80 JF - Revista da Associacao Medica Brasileira (1992) JO - Rev Assoc Med Bras (1992) VL - 61 IS - 4 N2 - INTRODUCTION: the use of statins is associated with reduced cardiovascular risk in studies of primary and secondary prevention, and the reduction is directly proportional to the reduction of LDL-cholesterol. Recent evidence suggests that statins may be associated with a higher incidence of new cases of diabetes. The aim of this review is to explore this possibility, identifying factors associated with the increase in risk and the potential diabetogenic mechanisms of statins. In addition, we evaluated if the risk of diabetes interferes with the reduction in cardiovascular risk achieved with statins. METHODS: we reviewed articles published in the Scielo and Pubmed databases, which assessed or described the association between use of statins and risk of diabetes up to June 2015. RESULTS: use of statins is associated with a small increase in the incidence of new cases of diabetes. Age, potency of statin therapy, presence of metabolic syndrome, impaired fasting blood glucose, overweight and previously altered glycated hemoglobin levels are associated with increased risk of diabetes, but there is no consensus about the possible diabetogenic mechanisms of statins. In patients candidate to hypolipemiant drug therapy, the benefit of reducing cardiovascular risk outweighs any risk increase in the incidence of diabetes. CONCLUSION: statins are associated with a small increase in incidence of diabetes in patients predisposed to glycemic alteration. However, since the benefit of cardiovascular risk reduction prevails even in this group, there is no evidence to date that this finding should change the recommendation of starting statin therapy. SN - 1806-9282 UR - https://www.unboundmedicine.com/medline/citation/26466221/Use_of_statins_and_the_incidence_of_type_2_diabetes_mellitus_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302015000400375&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -