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Visual function and macular architecture in patients with inactive zone 2 and 3 toxoplasmic retinochoroiditis.
Arq Bras Oftalmol 2015 Sep-Oct; 78(5):273-7AB

Abstract

PURPOSE

To evaluate the visual function and architecture of the central and peripapillary retina in patients with inactive toxoplasmic retinochoroiditis outside the macular and peripapillary regions (zones 2 and 3).

METHODS

Cross-sectional study of 20 eyes (18 patients) with zone 2 and 3 toxoplasmic scars and visual acuity ≥20/25. Patients underwent Humphrey 10-2 perimetry, contrast sensitivity (Mars test), and color vision testing (L'Anthony desaturated D-15). The retinal nerve fiber layer (RNFL) and macular thicknesses were determined by optical coherence tomography.

RESULTS

The patients' mean age was 27.4 ± 10.3 years, and the mean duration of remission was 6.15 ± 5.19 months. Abnormal contrast sensitivity and color vision were observed in three (15.0%) and four eyes (20.0%), respectively. Mean deviation (MD) and pattern standard deviation (PSD) fell outside the 95% normal confidence limits of the perimeter's database in 14 (70.0%) and seven eyes (35.0%), respectively. Foveal and mean RNFL thicknesses were within the normal limits in all eyes. Eyes with zone 2 retinochoroiditis had lower foveal sensitivity than eyes with zone 3 lesions (p=0.041). Eyes with a longer duration of remission had a higher MD (r=0.575; p=0.013) and a lower PSD (r=-0.593; p=0.010).

CONCLUSIONS

Despite normal central and peripapillary retinal architecture, eyes with inactive zone 2 and 3 toxoplasmic retinochoroiditis can present with abnormal color, contrast, and macular perimetric sensitivity. Zone 2 retinochoroiditis was associated with lower foveal sensitivity, and a longer duration of retinochoroiditis remission was associated with better perimetric parameters (MD and PSD).

Authors+Show Affiliations

Fundação Altino Ventura, Recife, PE, BR.Fundação Altino Ventura, Recife, PE, BR.Fundação Altino Ventura, Recife, PE, BR.Departamento de Oftalmologia, Universidade Federal de São Paulo, São Paulo, SP, BR.Fundação Altino Ventura, Recife, PE, BR.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26466223

Citation

Azevedo, Mariana Honório de, et al. "Visual Function and Macular Architecture in Patients With Inactive Zone 2 and 3 Toxoplasmic Retinochoroiditis." Arquivos Brasileiros De Oftalmologia, vol. 78, no. 5, 2015, pp. 273-7.
Azevedo MH, Moura GL, Camilo EN, et al. Visual function and macular architecture in patients with inactive zone 2 and 3 toxoplasmic retinochoroiditis. Arq Bras Oftalmol. 2015;78(5):273-7.
Azevedo, M. H., Moura, G. L., Camilo, E. N., Muccioli, C., & Arantes, T. E. (2015). Visual function and macular architecture in patients with inactive zone 2 and 3 toxoplasmic retinochoroiditis. Arquivos Brasileiros De Oftalmologia, 78(5), pp. 273-7. doi:10.5935/0004-2749.20150073.
Azevedo MH, et al. Visual Function and Macular Architecture in Patients With Inactive Zone 2 and 3 Toxoplasmic Retinochoroiditis. Arq Bras Oftalmol. 2015;78(5):273-7. PubMed PMID: 26466223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visual function and macular architecture in patients with inactive zone 2 and 3 toxoplasmic retinochoroiditis. AU - Azevedo,Mariana Honório de, AU - Moura,Guilherme Lucena, AU - Camilo,Eduardo Nery Rossi, AU - Muccioli,Cristina, AU - Arantes,Tiago Eugênio Faria e, PY - 2015/01/16/received PY - 2015/06/01/accepted PY - 2015/10/15/entrez PY - 2015/10/16/pubmed PY - 2016/4/12/medline SP - 273 EP - 7 JF - Arquivos brasileiros de oftalmologia JO - Arq Bras Oftalmol VL - 78 IS - 5 N2 - PURPOSE: To evaluate the visual function and architecture of the central and peripapillary retina in patients with inactive toxoplasmic retinochoroiditis outside the macular and peripapillary regions (zones 2 and 3). METHODS: Cross-sectional study of 20 eyes (18 patients) with zone 2 and 3 toxoplasmic scars and visual acuity ≥20/25. Patients underwent Humphrey 10-2 perimetry, contrast sensitivity (Mars test), and color vision testing (L'Anthony desaturated D-15). The retinal nerve fiber layer (RNFL) and macular thicknesses were determined by optical coherence tomography. RESULTS: The patients' mean age was 27.4 ± 10.3 years, and the mean duration of remission was 6.15 ± 5.19 months. Abnormal contrast sensitivity and color vision were observed in three (15.0%) and four eyes (20.0%), respectively. Mean deviation (MD) and pattern standard deviation (PSD) fell outside the 95% normal confidence limits of the perimeter's database in 14 (70.0%) and seven eyes (35.0%), respectively. Foveal and mean RNFL thicknesses were within the normal limits in all eyes. Eyes with zone 2 retinochoroiditis had lower foveal sensitivity than eyes with zone 3 lesions (p=0.041). Eyes with a longer duration of remission had a higher MD (r=0.575; p=0.013) and a lower PSD (r=-0.593; p=0.010). CONCLUSIONS: Despite normal central and peripapillary retinal architecture, eyes with inactive zone 2 and 3 toxoplasmic retinochoroiditis can present with abnormal color, contrast, and macular perimetric sensitivity. Zone 2 retinochoroiditis was associated with lower foveal sensitivity, and a longer duration of retinochoroiditis remission was associated with better perimetric parameters (MD and PSD). SN - 1678-2925 UR - https://www.unboundmedicine.com/medline/citation/26466223/Visual_function_and_macular_architecture_in_patients_with_inactive_zone_2_and_3_toxoplasmic_retinochoroiditis_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000550073&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -