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Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis.
J Obstet Gynaecol. 2016; 36(3):301-11.JO

Abstract

This study evaluated the efficacy of red clover to relieve hot flashes and menopausal symptoms in peri/postmenopausal women. Electronic databases (MEDLINE, Scopus and the Cochrane Library) were searched. The mean frequency of hot flashes in red clover groups was lower compared with that in the control groups (close to statistical significance). Difference in means (MD) of hot flashes frequency was - 1.99 (- 4.12-0.139; p = 0.067; heterogeneity P > 0.01; I(2) = 94.93%; Random effect model). Subjective (vaginal dryness) and objective (maturation value) symptoms of vaginal atrophy showed a significant improvement with 80-mg dose of red clover. Red clover showed less therapeutic effect on psychology status, sexual problems and sleeping disorders. Red clover consumption may decrease frequency of hot flashes, especially in women with severe hot flashes (≥ 5 per day). Red clover may reduce other menopausal symptoms. Further trials are needed to confirm the current systematic review findings.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ghazanfarpour M
a Department of Midwifery , Student Research Committee, Nursing and Midwifery School, Mashhad University of Medical Science , Mashhad , Iran.
Sadeghi R
b Nuclear Medicine Research Center, Mashhad University of Medical Sciences , Mashhad , Iran.
Roudsari RL
c Department of Midwifery , Evidence-Based Care Research Centre, School of Nursing and Midwifery, Mashhad University of Medical Sciences , Mashhad , Iran.
Khorsand I
d Department of Microbiology , Islamic Azad University of Varamin-pishva , Pishva, Tehran , Iran.
Khadivzadeh T
e Student Research Committee. f Evidence-Based Care Research Centre, Department of Midwifery , School of Nursing and Midwifery, Mashhad University of Medical Sciences , Mashhad , Iran.
Muoio B
f Evidence-Based Care Research Centre, Department of Midwifery , School of Nursing and Midwifery, Mashhad University of Medical Sciences , Mashhad , Iran.

MeSH

AnxietyBone and BonesDepressionFemaleHot FlashesHumansMenopausePhytotherapyPlant ExtractsSexual Dysfunction, PhysiologicalSleepTrifoliumVaginaVasomotor System

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

26471215

Citation

Ghazanfarpour, M, et al. "Red Clover for Treatment of Hot Flashes and Menopausal Symptoms: a Systematic Review and Meta-analysis." Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology, vol. 36, no. 3, 2016, pp. 301-11.
Ghazanfarpour M, Sadeghi R, Roudsari RL, et al. Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis. J Obstet Gynaecol. 2016;36(3):301-11.
Ghazanfarpour, M., Sadeghi, R., Roudsari, R. L., Khorsand, I., Khadivzadeh, T., & Muoio, B. (2016). Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis. Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology, 36(3), 301-11. https://doi.org/10.3109/01443615.2015.1049249
Ghazanfarpour M, et al. Red Clover for Treatment of Hot Flashes and Menopausal Symptoms: a Systematic Review and Meta-analysis. J Obstet Gynaecol. 2016;36(3):301-11. PubMed PMID: 26471215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis. AU - Ghazanfarpour,M, AU - Sadeghi,R, AU - Roudsari,R Latifnejad, AU - Khorsand,I, AU - Khadivzadeh,T, AU - Muoio,B, Y1 - 2015/10/15/ PY - 2015/10/17/entrez PY - 2015/10/17/pubmed PY - 2017/1/31/medline KW - Hot flushes KW - menopause KW - meta-analysis KW - red clover KW - systematic review SP - 301 EP - 11 JF - Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology JO - J Obstet Gynaecol VL - 36 IS - 3 N2 - This study evaluated the efficacy of red clover to relieve hot flashes and menopausal symptoms in peri/postmenopausal women. Electronic databases (MEDLINE, Scopus and the Cochrane Library) were searched. The mean frequency of hot flashes in red clover groups was lower compared with that in the control groups (close to statistical significance). Difference in means (MD) of hot flashes frequency was - 1.99 (- 4.12-0.139; p = 0.067; heterogeneity P > 0.01; I(2) = 94.93%; Random effect model). Subjective (vaginal dryness) and objective (maturation value) symptoms of vaginal atrophy showed a significant improvement with 80-mg dose of red clover. Red clover showed less therapeutic effect on psychology status, sexual problems and sleeping disorders. Red clover consumption may decrease frequency of hot flashes, especially in women with severe hot flashes (≥ 5 per day). Red clover may reduce other menopausal symptoms. Further trials are needed to confirm the current systematic review findings. SN - 1364-6893 UR - https://www.unboundmedicine.com/medline/citation/26471215/Red_clover_for_treatment_of_hot_flashes_and_menopausal_symptoms:_A_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -