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Mechanism of immunoprotective effects of curcumin in DLM-induced thymic apoptosis and altered immune function: an in silico and in vitro study.
Immunopharmacol Immunotoxicol. 2015; 37(6):488-98.II

Abstract

Curcumin, a main component of Curcuma Longa Linn, is a plant polyphenol used as an immune-enhancer in the Indian system of traditional medicine. However, its underlying mechanism of immune-protection remains unknown. The present study is designed to delineate the role of curcumin in deltamethrin (DLM)-induced thymocyte apoptosis and altered immune functions. In silico studies revealed that curcumin has a strong binding affinity toward CD4 and CD8 receptors. DLM (25 µM) induces thymocytes apoptosis through oxidative stress and caspase-dependent pathways. Various concentrations of curcumin (1, 10 and 50 µg/ml), when added along with DLM, caused a concentration- and time-related amelioration in apoptogenic signaling pathways induced by DLM. Inhibition of DLM-induced reactive oxygen species production, replenishment of glutathione and suppression of caspase activities by curcumin may thus be responsible for the suppression of downstream cascade of events, i.e. apoptosis, phenotypic changes and altered cytokine release. Thus, this study clearly demonstrates that the mechanism of immunoprotection of curcumin in DLM-induced thymic apoptosis includes inhibition of oxidative stress and caspase-dependent pathways underlying apoptosis.

Authors+Show Affiliations

a Department of Pharmaceutical Sciences and Technology , Birla Institute of Technology , Ranchi , Jharkhand , India.a Department of Pharmaceutical Sciences and Technology , Birla Institute of Technology , Ranchi , Jharkhand , India.a Department of Pharmaceutical Sciences and Technology , Birla Institute of Technology , Ranchi , Jharkhand , India.a Department of Pharmaceutical Sciences and Technology , Birla Institute of Technology , Ranchi , Jharkhand , India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26471321

Citation

Kumar, Anoop, et al. "Mechanism of Immunoprotective Effects of Curcumin in DLM-induced Thymic Apoptosis and Altered Immune Function: an in Silico and in Vitro Study." Immunopharmacology and Immunotoxicology, vol. 37, no. 6, 2015, pp. 488-98.
Kumar A, Sasmal D, Jadav SS, et al. Mechanism of immunoprotective effects of curcumin in DLM-induced thymic apoptosis and altered immune function: an in silico and in vitro study. Immunopharmacol Immunotoxicol. 2015;37(6):488-98.
Kumar, A., Sasmal, D., Jadav, S. S., & Sharma, N. (2015). Mechanism of immunoprotective effects of curcumin in DLM-induced thymic apoptosis and altered immune function: an in silico and in vitro study. Immunopharmacology and Immunotoxicology, 37(6), 488-98. https://doi.org/10.3109/08923973.2015.1091004
Kumar A, et al. Mechanism of Immunoprotective Effects of Curcumin in DLM-induced Thymic Apoptosis and Altered Immune Function: an in Silico and in Vitro Study. Immunopharmacol Immunotoxicol. 2015;37(6):488-98. PubMed PMID: 26471321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanism of immunoprotective effects of curcumin in DLM-induced thymic apoptosis and altered immune function: an in silico and in vitro study. AU - Kumar,Anoop, AU - Sasmal,Dinakar, AU - Jadav,Surender Singh, AU - Sharma,Neelima, Y1 - 2015/10/15/ PY - 2015/10/17/entrez PY - 2015/10/17/pubmed PY - 2016/9/13/medline KW - Apoptosis KW - curcumin KW - deltamethrin KW - oxidative stress KW - phenotyping SP - 488 EP - 98 JF - Immunopharmacology and immunotoxicology JO - Immunopharmacol Immunotoxicol VL - 37 IS - 6 N2 - Curcumin, a main component of Curcuma Longa Linn, is a plant polyphenol used as an immune-enhancer in the Indian system of traditional medicine. However, its underlying mechanism of immune-protection remains unknown. The present study is designed to delineate the role of curcumin in deltamethrin (DLM)-induced thymocyte apoptosis and altered immune functions. In silico studies revealed that curcumin has a strong binding affinity toward CD4 and CD8 receptors. DLM (25 µM) induces thymocytes apoptosis through oxidative stress and caspase-dependent pathways. Various concentrations of curcumin (1, 10 and 50 µg/ml), when added along with DLM, caused a concentration- and time-related amelioration in apoptogenic signaling pathways induced by DLM. Inhibition of DLM-induced reactive oxygen species production, replenishment of glutathione and suppression of caspase activities by curcumin may thus be responsible for the suppression of downstream cascade of events, i.e. apoptosis, phenotypic changes and altered cytokine release. Thus, this study clearly demonstrates that the mechanism of immunoprotection of curcumin in DLM-induced thymic apoptosis includes inhibition of oxidative stress and caspase-dependent pathways underlying apoptosis. SN - 1532-2513 UR - https://www.unboundmedicine.com/medline/citation/26471321/Mechanism_of_immunoprotective_effects_of_curcumin_in_DLM_induced_thymic_apoptosis_and_altered_immune_function:_an_in_silico_and_in_vitro_study_ L2 - https://www.tandfonline.com/doi/full/10.3109/08923973.2015.1091004 DB - PRIME DP - Unbound Medicine ER -