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Autoimmune diseases and celiac disease which came first: genotype or gluten?
Expert Rev Clin Immunol 2016; 12(1):67-77ER

Abstract

Celiac disease (CD) is associated with several autoimmune diseases (ADs) and, in particular, thyroid autoimmunity (TA) and Type 1 diabetes (T1D). TA and T1D are defined as 'associated conditions' to CD (conditions at increased prevalence in CD but not directly related to gluten ingestion). The diagnosis of CD may precede or follow that of TA/T1D. To date, the available evidence suggests that the common genetic background is the main factor determining the high prevalence of the association. Conversely, no conclusive findings clarify whether extrinsic gluten-related factors (age at the first introduction, concomitant breastfeeding, length of gluten exposure and gluten-free diet) may link CD to the ADs. The aim of this review is to evaluate whether genetic background alone could explain the association between CD and ADs or if gluten-related factors ought to be considered. The pathophysiological links clarifying how the gluten-related factors could predispose to ADs will also be discussed.

Authors+Show Affiliations

a 1 Artificial Nutrition Unit, Epato-Gastroenterology and Nutrition, Pediatric Hospital "Bambino Gesù", Rome, Italy.a 1 Artificial Nutrition Unit, Epato-Gastroenterology and Nutrition, Pediatric Hospital "Bambino Gesù", Rome, Italy.b 2 Endocrinology Unit, Pediatric Hospital "Bambino Gesù", Rome, Italy.c 3 Hepato-Metabolic Disease Unit, Pediatric Hospital "Bambino Gesù", Rome, Italy.a 1 Artificial Nutrition Unit, Epato-Gastroenterology and Nutrition, Pediatric Hospital "Bambino Gesù", Rome, Italy.a 1 Artificial Nutrition Unit, Epato-Gastroenterology and Nutrition, Pediatric Hospital "Bambino Gesù", Rome, Italy.a 1 Artificial Nutrition Unit, Epato-Gastroenterology and Nutrition, Pediatric Hospital "Bambino Gesù", Rome, Italy.a 1 Artificial Nutrition Unit, Epato-Gastroenterology and Nutrition, Pediatric Hospital "Bambino Gesù", Rome, Italy.d 4 Scientific Directorate, Pediatric Hospital "Bambino Gesù", Rome, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26471843

Citation

Diamanti, Antonella, et al. "Autoimmune Diseases and Celiac Disease Which Came First: Genotype or Gluten?" Expert Review of Clinical Immunology, vol. 12, no. 1, 2016, pp. 67-77.
Diamanti A, Capriati T, Bizzarri C, et al. Autoimmune diseases and celiac disease which came first: genotype or gluten? Expert Rev Clin Immunol. 2016;12(1):67-77.
Diamanti, A., Capriati, T., Bizzarri, C., Ferretti, F., Ancinelli, M., Romano, F., ... Locatelli, M. (2016). Autoimmune diseases and celiac disease which came first: genotype or gluten? Expert Review of Clinical Immunology, 12(1), pp. 67-77. doi:10.1586/1744666X.2016.1095091.
Diamanti A, et al. Autoimmune Diseases and Celiac Disease Which Came First: Genotype or Gluten. Expert Rev Clin Immunol. 2016;12(1):67-77. PubMed PMID: 26471843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoimmune diseases and celiac disease which came first: genotype or gluten? AU - Diamanti,Antonella, AU - Capriati,Teresa, AU - Bizzarri,Carla, AU - Ferretti,Francesca, AU - Ancinelli,Monica, AU - Romano,Francesca, AU - Perilli,Alessia, AU - Laureti,Francesca, AU - Locatelli,Mattia, Y1 - 2015/10/16/ PY - 2015/10/17/entrez PY - 2015/10/17/pubmed PY - 2016/8/30/medline KW - adolescent KW - autoimmune diseases KW - celiac disease KW - child KW - thyroid autoimmunity KW - type 1 diabetes SP - 67 EP - 77 JF - Expert review of clinical immunology JO - Expert Rev Clin Immunol VL - 12 IS - 1 N2 - Celiac disease (CD) is associated with several autoimmune diseases (ADs) and, in particular, thyroid autoimmunity (TA) and Type 1 diabetes (T1D). TA and T1D are defined as 'associated conditions' to CD (conditions at increased prevalence in CD but not directly related to gluten ingestion). The diagnosis of CD may precede or follow that of TA/T1D. To date, the available evidence suggests that the common genetic background is the main factor determining the high prevalence of the association. Conversely, no conclusive findings clarify whether extrinsic gluten-related factors (age at the first introduction, concomitant breastfeeding, length of gluten exposure and gluten-free diet) may link CD to the ADs. The aim of this review is to evaluate whether genetic background alone could explain the association between CD and ADs or if gluten-related factors ought to be considered. The pathophysiological links clarifying how the gluten-related factors could predispose to ADs will also be discussed. SN - 1744-8409 UR - https://www.unboundmedicine.com/medline/citation/26471843/Autoimmune_diseases_and_celiac_disease_which_came_first:_genotype_or_gluten L2 - http://www.tandfonline.com/doi/full/10.1586/1744666X.2016.1095091 DB - PRIME DP - Unbound Medicine ER -