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Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice.
Eur J Pharmacol. 2015 Nov 15; 767:119-25.EJ

Abstract

Neuropeptide FF (NPFF) system has recently been reported to modulate cannabinoid-induced antinociception. The aim of the present study was to further investigate the roles of NPFF system in the antinociceptive effects induced by intracerebroventricular (i.c.v.) administration of mouse VD-hemopressin(α), a novel endogenous agonist of cannabinoid CB1 receptor, in naive and VD-hemopressin(α)-tolerant mice. The effects of NPFF system on the antinociception induced by VD-hemopressin(α) were investigated in the radiant heat tail-flick test in naive mice and VD-hemopressin(α)-tolerant mice. The cannabinoid-tolerant mice were produced by given daily injections of VD-hemopressin(α) (20 nmol, i.c.v.) for 5 days and the antinociception was measured on day 6. In naive mice, intracerebroventricular injection of NPFF dose-dependently attenuated central analgesia of VD-hemopressin(α). In contrast, neuropeptide VF (NPVF) and D.NP(N-Me)AFLFQPQRF-NH2 (dNPA), two highly selective agonists for Neuropeptide FF1 and Neuropeptide FF2 receptors, enhanced VD-hemopressin(α)-induced antinociception in a dose-dependent manner. In addition, the VD-hemopressin(α)-modulating activities of NPFF and related peptides were antagonized by the Neuropeptide FF receptors selective antagonist 1-adamantanecarbonyl-RF-NH2 (RF9). In VD-hemopressin(α)-tolerant mice, NPFF failed to modify VD-hemopressin(α)-induced antinociception. However, both neuropeptide VF and dNPA dose-dependently potentiated the antinociception of VD-hemopressin(α) and these cannabinoid-potentiating effects were reduced by RF9. The present works support the cannabinoid-modulating character of NPFF system in naive and cannabinoid-tolerant mice. In addition, the data suggest that a chronic cannabinoid treatment modifies the pharmacological profiles of NPFF, but not the cannabinoid-potentiating effects of neuropeptide VF and dNPA.

Authors+Show Affiliations

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China. Electronic address: fangq@lzu.edu.cn.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China. Electronic address: wangrui@lzu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26472125

Citation

Pan, Jia-Xin, et al. "Effects of Neuropeptide FF and Related Peptides On the Antinociceptive Activities of VD-hemopressin(α) in Naive and Cannabinoid-tolerant Mice." European Journal of Pharmacology, vol. 767, 2015, pp. 119-25.
Pan JX, Wang ZL, Li N, et al. Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice. Eur J Pharmacol. 2015;767:119-25.
Pan, J. X., Wang, Z. L., Li, N., Zhang, N., Wang, P., Tang, H. H., Zhang, T., Yu, H. P., Zhang, R., Zheng, T., Fang, Q., & Wang, R. (2015). Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice. European Journal of Pharmacology, 767, 119-25. https://doi.org/10.1016/j.ejphar.2015.10.016
Pan JX, et al. Effects of Neuropeptide FF and Related Peptides On the Antinociceptive Activities of VD-hemopressin(α) in Naive and Cannabinoid-tolerant Mice. Eur J Pharmacol. 2015 Nov 15;767:119-25. PubMed PMID: 26472125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice. AU - Pan,Jia-Xin, AU - Wang,Zi-Long, AU - Li,Ning, AU - Zhang,Nan, AU - Wang,Pei, AU - Tang,Hong-Hai, AU - Zhang,Ting, AU - Yu,Hong-Ping, AU - Zhang,Run, AU - Zheng,Ting, AU - Fang,Quan, AU - Wang,Rui, Y1 - 2015/10/16/ PY - 2015/07/15/received PY - 2015/09/20/revised PY - 2015/10/08/accepted PY - 2015/10/17/entrez PY - 2015/10/17/pubmed PY - 2016/10/7/medline KW - 1DMe (PubChem CID: 71345956) KW - 2-arachidonoylglycerol (PubChem CID: 5282280) KW - Antinociception KW - Cannabinoids KW - Hemopressin (PubChem CID: 71312009) KW - Hu-210 (PubChem CID: 9821569) KW - Mice KW - NPFF (PubChem CID: 123797) KW - Neuropeptide FF KW - Neuropeptide VF (PubChem CID: 71451611) KW - RF9 (PubChem CID: 53320361) KW - RVD-hemopressin(α) (PubChem CID: 90488874) KW - Tolerance KW - VD-hemopressin(α) KW - WIN55,212-2 (PubChem CID: 6604176) KW - Δ(9)-tetrahydrocannabinol (PubChem CID: 16078) SP - 119 EP - 25 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 767 N2 - Neuropeptide FF (NPFF) system has recently been reported to modulate cannabinoid-induced antinociception. The aim of the present study was to further investigate the roles of NPFF system in the antinociceptive effects induced by intracerebroventricular (i.c.v.) administration of mouse VD-hemopressin(α), a novel endogenous agonist of cannabinoid CB1 receptor, in naive and VD-hemopressin(α)-tolerant mice. The effects of NPFF system on the antinociception induced by VD-hemopressin(α) were investigated in the radiant heat tail-flick test in naive mice and VD-hemopressin(α)-tolerant mice. The cannabinoid-tolerant mice were produced by given daily injections of VD-hemopressin(α) (20 nmol, i.c.v.) for 5 days and the antinociception was measured on day 6. In naive mice, intracerebroventricular injection of NPFF dose-dependently attenuated central analgesia of VD-hemopressin(α). In contrast, neuropeptide VF (NPVF) and D.NP(N-Me)AFLFQPQRF-NH2 (dNPA), two highly selective agonists for Neuropeptide FF1 and Neuropeptide FF2 receptors, enhanced VD-hemopressin(α)-induced antinociception in a dose-dependent manner. In addition, the VD-hemopressin(α)-modulating activities of NPFF and related peptides were antagonized by the Neuropeptide FF receptors selective antagonist 1-adamantanecarbonyl-RF-NH2 (RF9). In VD-hemopressin(α)-tolerant mice, NPFF failed to modify VD-hemopressin(α)-induced antinociception. However, both neuropeptide VF and dNPA dose-dependently potentiated the antinociception of VD-hemopressin(α) and these cannabinoid-potentiating effects were reduced by RF9. The present works support the cannabinoid-modulating character of NPFF system in naive and cannabinoid-tolerant mice. In addition, the data suggest that a chronic cannabinoid treatment modifies the pharmacological profiles of NPFF, but not the cannabinoid-potentiating effects of neuropeptide VF and dNPA. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/26472125/Effects_of_neuropeptide_FF_and_related_peptides_on_the_antinociceptive_activities_of_VD_hemopressin_α__in_naive_and_cannabinoid_tolerant_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(15)30297-1 DB - PRIME DP - Unbound Medicine ER -