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Daily supplementation with mushroom (Agaricus bisporus) improves balance and working memory in aged rats.
Nutr Res. 2015 Dec; 35(12):1079-84.NR

Abstract

Decline in brain function during normal aging is partly due to the long-term effects of oxidative stress and inflammation. Several fruits and vegetables have been shown to possess antioxidant and anti-inflammatory properties. The present study investigated the effects of dietary mushroom intervention on mobility and memory in aged Fischer 344 rats. We hypothesized that daily supplementation of mushroom would have beneficial effects on behavioral outcomes in a dose-dependent manner. Rats were randomly assigned to receive a diet containing either 0%, 0.5%, 1%, 2%, or 5% lyophilized white button mushroom (Agaricus bisporus); after 8 weeks on the diet, a battery of behavioral tasks was given to assess balance, coordination, and cognition. Rats on the 2% or 5% mushroom-supplemented diet consumed more food, without gaining weight, than rats in the other diet groups. Rats in the 0.5% and 1% group stayed on a narrow beam longer, indicating an improvement in balance. Only rats on the 0.5% mushroom diet showed improved performance in a working memory version of the Morris water maze. When taken together, the most effective mushroom dose that produced improvements in both balance and working memory was 0.5%, equivalent to about 1.5 ounces of fresh mushrooms for humans. Therefore, the results suggest that the inclusion of mushroom in the daily diet may have beneficial effects on age-related deficits in cognitive and motor function.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA.USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA.USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA.USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Electronic address: barbara.shukitthale@ars.usda.gov.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

26475179

Citation

Thangthaeng, Nopporn, et al. "Daily Supplementation With Mushroom (Agaricus Bisporus) Improves Balance and Working Memory in Aged Rats." Nutrition Research (New York, N.Y.), vol. 35, no. 12, 2015, pp. 1079-84.
Thangthaeng N, Miller MG, Gomes SM, et al. Daily supplementation with mushroom (Agaricus bisporus) improves balance and working memory in aged rats. Nutr Res. 2015;35(12):1079-84.
Thangthaeng, N., Miller, M. G., Gomes, S. M., & Shukitt-Hale, B. (2015). Daily supplementation with mushroom (Agaricus bisporus) improves balance and working memory in aged rats. Nutrition Research (New York, N.Y.), 35(12), 1079-84. https://doi.org/10.1016/j.nutres.2015.09.012
Thangthaeng N, et al. Daily Supplementation With Mushroom (Agaricus Bisporus) Improves Balance and Working Memory in Aged Rats. Nutr Res. 2015;35(12):1079-84. PubMed PMID: 26475179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Daily supplementation with mushroom (Agaricus bisporus) improves balance and working memory in aged rats. AU - Thangthaeng,Nopporn, AU - Miller,Marshall G, AU - Gomes,Stacey M, AU - Shukitt-Hale,Barbara, Y1 - 2015/10/05/ PY - 2015/02/03/received PY - 2015/09/18/revised PY - 2015/09/21/accepted PY - 2015/10/18/entrez PY - 2015/10/18/pubmed PY - 2016/9/23/medline KW - Agaricus bisporus KW - Aging KW - Balance KW - Diet KW - Memory KW - White button mushroom SP - 1079 EP - 84 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 35 IS - 12 N2 - Decline in brain function during normal aging is partly due to the long-term effects of oxidative stress and inflammation. Several fruits and vegetables have been shown to possess antioxidant and anti-inflammatory properties. The present study investigated the effects of dietary mushroom intervention on mobility and memory in aged Fischer 344 rats. We hypothesized that daily supplementation of mushroom would have beneficial effects on behavioral outcomes in a dose-dependent manner. Rats were randomly assigned to receive a diet containing either 0%, 0.5%, 1%, 2%, or 5% lyophilized white button mushroom (Agaricus bisporus); after 8 weeks on the diet, a battery of behavioral tasks was given to assess balance, coordination, and cognition. Rats on the 2% or 5% mushroom-supplemented diet consumed more food, without gaining weight, than rats in the other diet groups. Rats in the 0.5% and 1% group stayed on a narrow beam longer, indicating an improvement in balance. Only rats on the 0.5% mushroom diet showed improved performance in a working memory version of the Morris water maze. When taken together, the most effective mushroom dose that produced improvements in both balance and working memory was 0.5%, equivalent to about 1.5 ounces of fresh mushrooms for humans. Therefore, the results suggest that the inclusion of mushroom in the daily diet may have beneficial effects on age-related deficits in cognitive and motor function. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/26475179/Daily_supplementation_with_mushroom__Agaricus_bisporus__improves_balance_and_working_memory_in_aged_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(15)00225-0 DB - PRIME DP - Unbound Medicine ER -