Tags

Type your tag names separated by a space and hit enter

Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic.
Br J Anaesth. 2015 Nov; 115(5):752-60.BJ

Abstract

BACKGROUND

We tested the hypothesis that developmental effects of repeated neonatal exposure to sevoflurane in rats are exacerbated by stressful experiences received later in life.

METHODS

Sprague-Dawley male rats received sequential exposures to 3% sevoflurane for two h on postnatal days (P) six, seven, and eight. After weaning at P21, rats were housed either in pairs in an enriched environment (EE) or singly in an enrichment-deprived environment (an adverse environment, AE). The hippocampal concentrations of brain-derived neurotrophic factor (BDNF), and synaptic markers were assessed at P8 and P53. The dentate gyrus neural progenitor proliferation was evaluated at P11 and P53 after administration of bromodeoyuridine (BrdU) at P8 to P10 and at P22 to P27, respectively. Neurobehavioural evaluations were performed at P49 to P53.

RESULTS

Repeated sevoflurane exposure acutely reduced concentrations of BDNF, synaptic markers and neural progenitor proliferation. The sevoflurane group housed in the AE conditions (sevoflurane+AE) had decreased concentrations of BDNF and synaptic markers, and survival of new granule cells and impaired cognitive function compared with the control+AE, control+EE, and sevoflurane+EE groups. The neurobehavioural parameters in the sevoflurane+EE and control+EE groups were similar.

CONCLUSIONS

Neurocognitive abnormalities induced by repeated neonatal exposure to sevoflurane can be aggravated by stressful conditions such as social isolation and enrichment deprivation.

Authors+Show Affiliations

Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China Jiangsu Province Key Laboratory of Anaesthesiology, Xuzhou Medical College, Xuzhou, China Jiangsu Province Key Laboratory of Anaesthesia and Analgesia Application Technology, Xuzhou, China.Department of Anaesthesiology, University of Florida College of Medicine, Gainesville, FL, USA.Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China Jiangsu Province Key Laboratory of Anaesthesiology, Xuzhou Medical College, Xuzhou, China Jiangsu Province Key Laboratory of Anaesthesia and Analgesia Application Technology, Xuzhou, China yjyangjj@126.com amartynyuk@anest.ufl.edu.Department of Anaesthesiology, University of Florida College of Medicine, Gainesville, FL, USA The McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, USA yjyangjj@126.com amartynyuk@anest.ufl.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26475803

Citation

Zhang, M Q., et al. "Neurobehavioural Abnormalities Induced By Repeated Exposure of Neonatal Rats to Sevoflurane Can Be Aggravated By Social Isolation and Enrichment Deprivation Initiated After Exposure to the Anaesthetic." British Journal of Anaesthesia, vol. 115, no. 5, 2015, pp. 752-60.
Zhang MQ, Ji MH, Zhao QS, et al. Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic. Br J Anaesth. 2015;115(5):752-60.
Zhang, M. Q., Ji, M. H., Zhao, Q. S., Jia, M., Qiu, L. L., Yang, J. J., Peng, Y. G., Yang, J. J., & Martynyuk, A. E. (2015). Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic. British Journal of Anaesthesia, 115(5), 752-60. https://doi.org/10.1093/bja/aev339
Zhang MQ, et al. Neurobehavioural Abnormalities Induced By Repeated Exposure of Neonatal Rats to Sevoflurane Can Be Aggravated By Social Isolation and Enrichment Deprivation Initiated After Exposure to the Anaesthetic. Br J Anaesth. 2015;115(5):752-60. PubMed PMID: 26475803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic. AU - Zhang,M Q, AU - Ji,M H, AU - Zhao,Q S, AU - Jia,M, AU - Qiu,L L, AU - Yang,J J, AU - Peng,Y G, AU - Yang,J J, AU - Martynyuk,A E, PY - 2015/10/18/entrez PY - 2015/10/18/pubmed PY - 2016/1/26/medline KW - brain-derived neurotrophic factor KW - cognition KW - environment KW - rats KW - sevoflurane KW - social isolation SP - 752 EP - 60 JF - British journal of anaesthesia JO - Br J Anaesth VL - 115 IS - 5 N2 - BACKGROUND: We tested the hypothesis that developmental effects of repeated neonatal exposure to sevoflurane in rats are exacerbated by stressful experiences received later in life. METHODS: Sprague-Dawley male rats received sequential exposures to 3% sevoflurane for two h on postnatal days (P) six, seven, and eight. After weaning at P21, rats were housed either in pairs in an enriched environment (EE) or singly in an enrichment-deprived environment (an adverse environment, AE). The hippocampal concentrations of brain-derived neurotrophic factor (BDNF), and synaptic markers were assessed at P8 and P53. The dentate gyrus neural progenitor proliferation was evaluated at P11 and P53 after administration of bromodeoyuridine (BrdU) at P8 to P10 and at P22 to P27, respectively. Neurobehavioural evaluations were performed at P49 to P53. RESULTS: Repeated sevoflurane exposure acutely reduced concentrations of BDNF, synaptic markers and neural progenitor proliferation. The sevoflurane group housed in the AE conditions (sevoflurane+AE) had decreased concentrations of BDNF and synaptic markers, and survival of new granule cells and impaired cognitive function compared with the control+AE, control+EE, and sevoflurane+EE groups. The neurobehavioural parameters in the sevoflurane+EE and control+EE groups were similar. CONCLUSIONS: Neurocognitive abnormalities induced by repeated neonatal exposure to sevoflurane can be aggravated by stressful conditions such as social isolation and enrichment deprivation. SN - 1471-6771 UR - https://www.unboundmedicine.com/medline/citation/26475803/Neurobehavioural_abnormalities_induced_by_repeated_exposure_of_neonatal_rats_to_sevoflurane_can_be_aggravated_by_social_isolation_and_enrichment_deprivation_initiated_after_exposure_to_the_anaesthetic_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0007-0912(17)31077-2 DB - PRIME DP - Unbound Medicine ER -