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The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat.
Neuroscience. 2015 Dec 17; 311:118-29.N

Abstract

Paraquat (PQ) and maneb (MB) are potential risk factors for Parkinson's disease. However, their impact on non-motor disorders, monoamine neurotransmission and basal ganglia function is not clearly determined. Here we investigated the effects of combined treatment with PQ/MB on motor behavior, anxiety and "depressive-like" disorders, tissue content of monoamines, and subthalamic nucleus (STN) neuronal activity. Male Sprague-Dawley rats were intoxicated by PQ (10 mg/kg) and MB (30 mg/kg) twice a week. Two weeks later, the majority of animals (group 1, 16/26) showed a severe loss of body weight with tremor and respiratory distress and others (group 2, 6/26) showed only tremor. Animals of group 2 received PQ/MB during four weeks before developing weight loss. A last group (group 3, 4/26) was insensitive to PQ/MB after 6 weeks of injections. Groups 1 and 2 displayed a failure of motor activity and motor coordination. Group 3 showed slight motor deficits only after the last injection of PQ/MB. Moreover, PQ/MB induced anxiety and "depressive-like" behaviors in animals of groups 2 and 3. Biochemical analysis showed that PQ/MB reduced striatal dopamine (DA) tissue content paralleled by changes in the activity of STN neurons without changing the content of norepinephrine and serotonin in the cortex. Our data provide evidence that individuals are not equally sensitive to PQ/MB and show that the motor deficits in vulnerable animals, are not only a result of DA neuron degeneration, but may also be a consequence of peripheral disabilities. Nevertheless, the parkinsonian-like non-motor impairments may be a direct consequence of the bilateral DA depletion.

Authors+Show Affiliations

Univ. de Bordeaux, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France; Université Mohammed V, Faculté des Sciences, Equipe Rythmes Biologiques, Neurosciences et Environnement, Rabat, Morocco.Univ. de Bordeaux, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France; Université Mohammed V, Faculté des Sciences, Equipe Rythmes Biologiques, Neurosciences et Environnement, Rabat, Morocco.Univ. de Bordeaux, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France.Univ. de Bordeaux, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France.Université Mohammed V, Faculté des Sciences, Equipe Rythmes Biologiques, Neurosciences et Environnement, Rabat, Morocco.Univ. de Bordeaux, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des maladies neurodégénératives, UMR 5293, Bordeaux, France. Electronic address: abdelhamid.benazzouz@u-bordeaux.fr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26477982

Citation

Tinakoua, A, et al. "The Impact of Combined Administration of Paraquat and Maneb On Motor and Non-motor Functions in the Rat." Neuroscience, vol. 311, 2015, pp. 118-29.
Tinakoua A, Bouabid S, Faggiani E, et al. The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat. Neuroscience. 2015;311:118-29.
Tinakoua, A., Bouabid, S., Faggiani, E., De Deurwaerdère, P., Lakhdar-Ghazal, N., & Benazzouz, A. (2015). The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat. Neuroscience, 311, 118-29. https://doi.org/10.1016/j.neuroscience.2015.10.021
Tinakoua A, et al. The Impact of Combined Administration of Paraquat and Maneb On Motor and Non-motor Functions in the Rat. Neuroscience. 2015 Dec 17;311:118-29. PubMed PMID: 26477982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat. AU - Tinakoua,A, AU - Bouabid,S, AU - Faggiani,E, AU - De Deurwaerdère,P, AU - Lakhdar-Ghazal,N, AU - Benazzouz,A, Y1 - 2015/10/20/ PY - 2015/08/26/received PY - 2015/10/09/revised PY - 2015/10/12/accepted PY - 2015/10/20/entrez PY - 2015/10/20/pubmed PY - 2016/9/14/medline KW - Parkinson’s disease KW - dopamine KW - maneb KW - norepinephrine KW - paraquat KW - serotonin SP - 118 EP - 29 JF - Neuroscience JO - Neuroscience VL - 311 N2 - Paraquat (PQ) and maneb (MB) are potential risk factors for Parkinson's disease. However, their impact on non-motor disorders, monoamine neurotransmission and basal ganglia function is not clearly determined. Here we investigated the effects of combined treatment with PQ/MB on motor behavior, anxiety and "depressive-like" disorders, tissue content of monoamines, and subthalamic nucleus (STN) neuronal activity. Male Sprague-Dawley rats were intoxicated by PQ (10 mg/kg) and MB (30 mg/kg) twice a week. Two weeks later, the majority of animals (group 1, 16/26) showed a severe loss of body weight with tremor and respiratory distress and others (group 2, 6/26) showed only tremor. Animals of group 2 received PQ/MB during four weeks before developing weight loss. A last group (group 3, 4/26) was insensitive to PQ/MB after 6 weeks of injections. Groups 1 and 2 displayed a failure of motor activity and motor coordination. Group 3 showed slight motor deficits only after the last injection of PQ/MB. Moreover, PQ/MB induced anxiety and "depressive-like" behaviors in animals of groups 2 and 3. Biochemical analysis showed that PQ/MB reduced striatal dopamine (DA) tissue content paralleled by changes in the activity of STN neurons without changing the content of norepinephrine and serotonin in the cortex. Our data provide evidence that individuals are not equally sensitive to PQ/MB and show that the motor deficits in vulnerable animals, are not only a result of DA neuron degeneration, but may also be a consequence of peripheral disabilities. Nevertheless, the parkinsonian-like non-motor impairments may be a direct consequence of the bilateral DA depletion. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/26477982/The_impact_of_combined_administration_of_paraquat_and_maneb_on_motor_and_non_motor_functions_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(15)00928-8 DB - PRIME DP - Unbound Medicine ER -