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Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration.

Abstract

Controlled drug release is a process in which a predetermined amount of drug is released for longer period of time, ranging from days to months, in a controlled manner. In this study, novel drug delivery devices were fabricated via blend electrospinning and coaxial electrospinning using poly lactic glycolic acid (PLGA), gum tragacanth (GT) and tetracycline hydrochloride (TCH) as a hydrophilic model drug in different compositions and their performance as a drug carrier scaffold was evaluated. Scanning electron microscopy (SEM) results showed that fabricated PLGA, blend PLGA/GT and core shell PLGA/GT nanofibers had a smooth and bead-less morphology with the diameter ranging from 180 to 460 nm. Drug release studies showed that both the fraction of GT within blend nanofibers and the core-shell structure can effectively control TCH release rate from the nanofibrous membranes. By incorporation of TCH into core-shell nanofibers, drug release was sustained for 75 days with only 19% of burst release within the first 2h. The prolonged drug release, together with proven biocompatibility, antibacterial and mechanical properties of drug loaded core shell nanofibers make them a promising candidate to be used as drug delivery system for periodontal diseases.

Authors+Show Affiliations

Textile Engineering Group, Department of Engineering, University of Bonab, Bonab, Iran.Mechanical Engineering Department, National University of Singapore, Singapore; Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore.Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore. Electronic address: nnimpp@nus.edu.sg.Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran. Electronic address: hajirb@aut.ac.ir.Mechanical Engineering Department, National University of Singapore, Singapore; Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26478340

Citation

Ranjbar-Mohammadi, Marziyeh, et al. "Electrospinning of PLGA/gum Tragacanth Nanofibers Containing Tetracycline Hydrochloride for Periodontal Regeneration." Materials Science & Engineering. C, Materials for Biological Applications, vol. 58, 2016, pp. 521-31.
Ranjbar-Mohammadi M, Zamani M, Prabhakaran MP, et al. Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration. Mater Sci Eng C Mater Biol Appl. 2016;58:521-31.
Ranjbar-Mohammadi, M., Zamani, M., Prabhakaran, M. P., Bahrami, S. H., & Ramakrishna, S. (2016). Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration. Materials Science & Engineering. C, Materials for Biological Applications, 58, pp. 521-31. doi:10.1016/j.msec.2015.08.066.
Ranjbar-Mohammadi M, et al. Electrospinning of PLGA/gum Tragacanth Nanofibers Containing Tetracycline Hydrochloride for Periodontal Regeneration. Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:521-31. PubMed PMID: 26478340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration. AU - Ranjbar-Mohammadi,Marziyeh, AU - Zamani,M, AU - Prabhakaran,M P, AU - Bahrami,S Hajir, AU - Ramakrishna,S, Y1 - 2015/09/03/ PY - 2015/05/14/received PY - 2015/08/23/revised PY - 2015/08/27/accepted PY - 2015/10/20/entrez PY - 2015/10/20/pubmed PY - 2016/8/2/medline KW - Coaxial electrospinning KW - Electrospun nanofibers KW - Gum tragacanth KW - PLGA KW - Periodontal regeneration SP - 521 EP - 31 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 58 N2 - Controlled drug release is a process in which a predetermined amount of drug is released for longer period of time, ranging from days to months, in a controlled manner. In this study, novel drug delivery devices were fabricated via blend electrospinning and coaxial electrospinning using poly lactic glycolic acid (PLGA), gum tragacanth (GT) and tetracycline hydrochloride (TCH) as a hydrophilic model drug in different compositions and their performance as a drug carrier scaffold was evaluated. Scanning electron microscopy (SEM) results showed that fabricated PLGA, blend PLGA/GT and core shell PLGA/GT nanofibers had a smooth and bead-less morphology with the diameter ranging from 180 to 460 nm. Drug release studies showed that both the fraction of GT within blend nanofibers and the core-shell structure can effectively control TCH release rate from the nanofibrous membranes. By incorporation of TCH into core-shell nanofibers, drug release was sustained for 75 days with only 19% of burst release within the first 2h. The prolonged drug release, together with proven biocompatibility, antibacterial and mechanical properties of drug loaded core shell nanofibers make them a promising candidate to be used as drug delivery system for periodontal diseases. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/26478340/Electrospinning_of_PLGA/gum_tragacanth_nanofibers_containing_tetracycline_hydrochloride_for_periodontal_regeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-4931(15)30322-2 DB - PRIME DP - Unbound Medicine ER -