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Dihydrocodeine: safety concerns.
Expert Rev Clin Pharmacol. 2016; 9(1):9-12.ER

Abstract

Dihydrocodeine (DHC) is a semi-synthetic analogue of codeine, which was formed by the hydrogenation of the double tie in the main chain of the codeine molecule - instead of a double bond between carbons 7 and 8 DHC possesses a single bond. DHC is used as an analgesic and antitussive agent and for the management of dyspnea and opioid addiction. Limited data is available on the potency of DHC to other opioids. The analgesic effect of DHC is similar to codeine and approximately twice as potent as tramadol for an oral route. In contrast to codeine and tramadol, DHC analgesia seem to be irrespective of CYP2D6 activity due to parent compound analgesic effects, multiple metabolic pathways and limited role of dihydromorphine in DHC analgesia. As the drug is commonly available appropriate titration and dosing and knowledge of its metabolism and possible adverse effects are important for safe prescription of DHC.

Authors+Show Affiliations

a 1 Chair and Department of Palliative Medicine, Poznan University of Medical Sciences, Poznan, Poland.b 2 Medical College Jagiellonian University, Krakow, Poland.

Pub Type(s)

Editorial

Language

eng

PubMed ID

26479786

Citation

Leppert, Wojciech, and Jarosław Woroń. "Dihydrocodeine: Safety Concerns." Expert Review of Clinical Pharmacology, vol. 9, no. 1, 2016, pp. 9-12.
Leppert W, Woroń J. Dihydrocodeine: safety concerns. Expert Rev Clin Pharmacol. 2016;9(1):9-12.
Leppert, W., & Woroń, J. (2016). Dihydrocodeine: safety concerns. Expert Review of Clinical Pharmacology, 9(1), 9-12. https://doi.org/10.1586/17512433.2016.1092871
Leppert W, Woroń J. Dihydrocodeine: Safety Concerns. Expert Rev Clin Pharmacol. 2016;9(1):9-12. PubMed PMID: 26479786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dihydrocodeine: safety concerns. AU - Leppert,Wojciech, AU - Woroń,Jarosław, Y1 - 2015/10/19/ PY - 2015/10/20/entrez PY - 2015/10/20/pubmed PY - 2016/6/23/medline KW - adverse effects KW - analgesia KW - dihydrocodeine KW - opioids KW - safety SP - 9 EP - 12 JF - Expert review of clinical pharmacology JO - Expert Rev Clin Pharmacol VL - 9 IS - 1 N2 - Dihydrocodeine (DHC) is a semi-synthetic analogue of codeine, which was formed by the hydrogenation of the double tie in the main chain of the codeine molecule - instead of a double bond between carbons 7 and 8 DHC possesses a single bond. DHC is used as an analgesic and antitussive agent and for the management of dyspnea and opioid addiction. Limited data is available on the potency of DHC to other opioids. The analgesic effect of DHC is similar to codeine and approximately twice as potent as tramadol for an oral route. In contrast to codeine and tramadol, DHC analgesia seem to be irrespective of CYP2D6 activity due to parent compound analgesic effects, multiple metabolic pathways and limited role of dihydromorphine in DHC analgesia. As the drug is commonly available appropriate titration and dosing and knowledge of its metabolism and possible adverse effects are important for safe prescription of DHC. SN - 1751-2441 UR - https://www.unboundmedicine.com/medline/citation/26479786/Dihydrocodeine:_safety_concerns_ L2 - http://www.tandfonline.com/doi/full/10.1586/17512433.2016.1092871 DB - PRIME DP - Unbound Medicine ER -