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The specificity of the familial aggregation of early-onset bipolar disorder: A controlled 10-year follow-up study of offspring of parents with mood disorders.
J Affect Disord. 2016 Jan 15; 190:26-33.JA

Abstract

BACKGROUND

Two major sources of heterogeneity of mood disorders that have been demonstrated in clinical, family and genetic studies are the mood disorder subtype (i.e. bipolar (BPD) and major depressive disorder (MDD)) and age of onset of mood episodes. Using a prospective high-risk study design, our aims were to test the specificity of the parent-child transmission of BPD and MDD and to establish the risk of psychopathology in offspring in function of the age of onset of the parental disorder.

METHODS

Clinical information was collected on 208 probands (n=81 with BPD, n=64 with MDD, n=63 medical controls) as well as their 202 spouses and 372 children aged 6-17 years at study entry. Parents and children were directly interviewed every 3 years (mean duration of follow-up=10.6 years). Parental age of onset was dichotomized at age 21.

RESULTS

Offspring of parents with early onset BPD entailed a higher risk of BPD HR=7.9(1.8-34.6) and substance use disorders HR=5.0(1.1-21.9) than those with later onset and controls. Depressive disorders were not significantly increased in offspring regardless of parental mood disorder subtype or age of onset.

LIMITATIONS

Limited sample size, age of onset in probands was obtained retrospectively, age of onset in co-parents was not adequately documented, and a quarter of the children had no direct interview.

CONCLUSIONS

Our results provide support for the independence of familial aggregation of BPD from MDD and the heterogeneity of BPD based on patterns of onset. Future studies should further investigate correlates of early versus later onset BPD.

Authors+Show Affiliations

Department of Psychiatry, University Hospital of Lausanne, Switzerland.Department of Psychiatry, University Hospital of Lausanne, Switzerland.Department of Psychiatry, University Hospital of Lausanne, Switzerland.Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.Department of Psychiatry, University Hospital of Lausanne, Switzerland.Department of Psychiatry, University Hospital of Lausanne, Switzerland.Department of Mental Health and Psychiatry, University Hospital of Geneva, Switzerland.Department of Psychiatry, University Hospital of Lausanne, Switzerland. Electronic address: Caroline.Vandeleur@chuv.ch.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26480208

Citation

Preisig, Martin, et al. "The Specificity of the Familial Aggregation of Early-onset Bipolar Disorder: a Controlled 10-year Follow-up Study of Offspring of Parents With Mood Disorders." Journal of Affective Disorders, vol. 190, 2016, pp. 26-33.
Preisig M, Strippoli MF, Castelao E, et al. The specificity of the familial aggregation of early-onset bipolar disorder: A controlled 10-year follow-up study of offspring of parents with mood disorders. J Affect Disord. 2016;190:26-33.
Preisig, M., Strippoli, M. F., Castelao, E., Merikangas, K. R., Gholam-Rezaee, M., Marquet, P., Aubry, J. M., & Vandeleur, C. L. (2016). The specificity of the familial aggregation of early-onset bipolar disorder: A controlled 10-year follow-up study of offspring of parents with mood disorders. Journal of Affective Disorders, 190, 26-33. https://doi.org/10.1016/j.jad.2015.10.005
Preisig M, et al. The Specificity of the Familial Aggregation of Early-onset Bipolar Disorder: a Controlled 10-year Follow-up Study of Offspring of Parents With Mood Disorders. J Affect Disord. 2016 Jan 15;190:26-33. PubMed PMID: 26480208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The specificity of the familial aggregation of early-onset bipolar disorder: A controlled 10-year follow-up study of offspring of parents with mood disorders. AU - Preisig,Martin, AU - Strippoli,Marie-Pierre F, AU - Castelao,Enrique, AU - Merikangas,Kathleen Ries, AU - Gholam-Rezaee,Mehdi, AU - Marquet,Pierre, AU - Aubry,Jean-Michel, AU - Vandeleur,Caroline L, Y1 - 2015/10/23/ PY - 2015/06/23/received PY - 2015/09/29/revised PY - 2015/10/02/accepted PY - 2015/10/20/entrez PY - 2015/10/20/pubmed PY - 2016/7/21/medline KW - Age of onset KW - Family aggregation KW - High-risk study KW - Major depression KW - Mania KW - Substance use disorders SP - 26 EP - 33 JF - Journal of affective disorders JO - J Affect Disord VL - 190 N2 - BACKGROUND: Two major sources of heterogeneity of mood disorders that have been demonstrated in clinical, family and genetic studies are the mood disorder subtype (i.e. bipolar (BPD) and major depressive disorder (MDD)) and age of onset of mood episodes. Using a prospective high-risk study design, our aims were to test the specificity of the parent-child transmission of BPD and MDD and to establish the risk of psychopathology in offspring in function of the age of onset of the parental disorder. METHODS: Clinical information was collected on 208 probands (n=81 with BPD, n=64 with MDD, n=63 medical controls) as well as their 202 spouses and 372 children aged 6-17 years at study entry. Parents and children were directly interviewed every 3 years (mean duration of follow-up=10.6 years). Parental age of onset was dichotomized at age 21. RESULTS: Offspring of parents with early onset BPD entailed a higher risk of BPD HR=7.9(1.8-34.6) and substance use disorders HR=5.0(1.1-21.9) than those with later onset and controls. Depressive disorders were not significantly increased in offspring regardless of parental mood disorder subtype or age of onset. LIMITATIONS: Limited sample size, age of onset in probands was obtained retrospectively, age of onset in co-parents was not adequately documented, and a quarter of the children had no direct interview. CONCLUSIONS: Our results provide support for the independence of familial aggregation of BPD from MDD and the heterogeneity of BPD based on patterns of onset. Future studies should further investigate correlates of early versus later onset BPD. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/26480208/The_specificity_of_the_familial_aggregation_of_early_onset_bipolar_disorder:_A_controlled_10_year_follow_up_study_of_offspring_of_parents_with_mood_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(15)30476-6 DB - PRIME DP - Unbound Medicine ER -