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Characteristics of traditional Chinese medicine use in patients with rheumatoid arthritis in Taiwan: A nationwide population-based study.
J Ethnopharmacol. 2015 Dec 24; 176:9-16.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Large-scale study of traditional Chinese medicine (TCM) usage among patients with rheumatoid arthritis (RA) is lacking. The aim of this study is to evaluate the TCM usage among RA patients in Taiwan.

MATERIALS AND METHODS

We examined the "registry for catastrophic illness patient dataset" of the National Health Insurance Research Database (NHIRD; n=23 million people) in Taiwan. Patients (n=25,263) newly diagnosed as RA in 2001-2009 were included and then followed-up until the end of 2011. Based on the medical utilization, they were further categorized into TCM users (n= 6891; 27.3%) and non-TCM users (n=18,372; 72.7%). The demographic data and core prescription patterns of the TCM users were analyzed.

RESULTS

Compared to non-TCM user, TCM users were younger (mean age: 49.6 versus 54.0 years), had a higher female/male ratio (82.7%/17.3% versus 74.1%/25.9%), resided in more urbanized area. Herbal remedies were the most commonly used therapeutic approach (76.4%), followed by combining acupuncture (21.1%). The frequency of outpatient visits in TCM users was higher across all disease categories except circulatory system. The most commonly prescribed formula and herb was Shang-Jong-Shiah-Tong-Yong-Tong-Feng-Wan and Rhizoma Corydalis, respectively. The analysis of core pattern revealed that Dang-Gui-Nian-Tong-Tang, Shu-Jing-Huo-Xie-Tang, Gui-Zhi-Shao-Yao-Zhi-Mu-Tang, Myrrha and Olibanum, were among the most frequently used combinations. RA patients who had anxiety and depression, allergic rhinitis, osteoporosis, menstrual disorder, and menopausal syndrome were prone to have more TCM visits compared to non-TCM users.

CONCLUSIONS

Our population-based study revealed the high prevalence and specific usage patterns of TCM in the RA patients in Taiwan. The information could be used for further pharmacological investigation and clinical trials.

Authors+Show Affiliations

Graduate Institute of Chinese Medicine, China Medical University, Taichung 404, Taiwan; Department of Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan.Graduate Institute of Clinical Medicine, and Graduate Institute of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.Health Data Management Office, China Medical University Hospital, Taichung 404, Taiwan.Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan; Graduate Institute of Clinical Medicine, and Graduate Institute of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.Department of Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan; Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung 404, Taiwan; School of Chinese Medicine, China Medical University, Taichung 404, Taiwan.Department of Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan; Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung 404, Taiwan; Graduate Institute of Acupuncture Science, China Medical University, Taichung 404, Taiwan.Department of Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan; Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung 404, Taiwan; School of Chinese Medicine, China Medical University, Taichung 404, Taiwan.Graduate Institute of Chinese Medicine, China Medical University, Taichung 404, Taiwan; Department of Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan; Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung 404, Taiwan; School of Chinese Medicine, China Medical University, Taichung 404, Taiwan. Electronic address: hungrongyen@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26481605

Citation

Huang, Ming-Cheng, et al. "Characteristics of Traditional Chinese Medicine Use in Patients With Rheumatoid Arthritis in Taiwan: a Nationwide Population-based Study." Journal of Ethnopharmacology, vol. 176, 2015, pp. 9-16.
Huang MC, Pai FT, Lin CC, et al. Characteristics of traditional Chinese medicine use in patients with rheumatoid arthritis in Taiwan: A nationwide population-based study. J Ethnopharmacol. 2015;176:9-16.
Huang, M. C., Pai, F. T., Lin, C. C., Chang, C. M., Chang, H. H., Lee, Y. C., Sun, M. F., & Yen, H. R. (2015). Characteristics of traditional Chinese medicine use in patients with rheumatoid arthritis in Taiwan: A nationwide population-based study. Journal of Ethnopharmacology, 176, 9-16. https://doi.org/10.1016/j.jep.2015.10.024
Huang MC, et al. Characteristics of Traditional Chinese Medicine Use in Patients With Rheumatoid Arthritis in Taiwan: a Nationwide Population-based Study. J Ethnopharmacol. 2015 Dec 24;176:9-16. PubMed PMID: 26481605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of traditional Chinese medicine use in patients with rheumatoid arthritis in Taiwan: A nationwide population-based study. AU - Huang,Ming-Cheng, AU - Pai,Fu-Tzu, AU - Lin,Che-Chen, AU - Chang,Ching-Mao, AU - Chang,Hen-Hong, AU - Lee,Yu-Chen, AU - Sun,Mao-Feng, AU - Yen,Hung-Rong, Y1 - 2015/10/23/ PY - 2015/06/02/received PY - 2015/10/07/revised PY - 2015/10/12/accepted PY - 2015/10/21/entrez PY - 2015/10/21/pubmed PY - 2016/9/23/medline KW - National health insurance research database KW - Rheumatoid arthritis KW - Rhizoma Corydalis KW - Shang-Jong-Shiah-Tong-Yong-Tong-Feng-Wan KW - Traditional Chinese medicine KW - complementary and alternative medicine SP - 9 EP - 16 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 176 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Large-scale study of traditional Chinese medicine (TCM) usage among patients with rheumatoid arthritis (RA) is lacking. The aim of this study is to evaluate the TCM usage among RA patients in Taiwan. MATERIALS AND METHODS: We examined the "registry for catastrophic illness patient dataset" of the National Health Insurance Research Database (NHIRD; n=23 million people) in Taiwan. Patients (n=25,263) newly diagnosed as RA in 2001-2009 were included and then followed-up until the end of 2011. Based on the medical utilization, they were further categorized into TCM users (n= 6891; 27.3%) and non-TCM users (n=18,372; 72.7%). The demographic data and core prescription patterns of the TCM users were analyzed. RESULTS: Compared to non-TCM user, TCM users were younger (mean age: 49.6 versus 54.0 years), had a higher female/male ratio (82.7%/17.3% versus 74.1%/25.9%), resided in more urbanized area. Herbal remedies were the most commonly used therapeutic approach (76.4%), followed by combining acupuncture (21.1%). The frequency of outpatient visits in TCM users was higher across all disease categories except circulatory system. The most commonly prescribed formula and herb was Shang-Jong-Shiah-Tong-Yong-Tong-Feng-Wan and Rhizoma Corydalis, respectively. The analysis of core pattern revealed that Dang-Gui-Nian-Tong-Tang, Shu-Jing-Huo-Xie-Tang, Gui-Zhi-Shao-Yao-Zhi-Mu-Tang, Myrrha and Olibanum, were among the most frequently used combinations. RA patients who had anxiety and depression, allergic rhinitis, osteoporosis, menstrual disorder, and menopausal syndrome were prone to have more TCM visits compared to non-TCM users. CONCLUSIONS: Our population-based study revealed the high prevalence and specific usage patterns of TCM in the RA patients in Taiwan. The information could be used for further pharmacological investigation and clinical trials. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/26481605/Characteristics_of_traditional_Chinese_medicine_use_in_patients_with_rheumatoid_arthritis_in_Taiwan:_A_nationwide_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(15)30182-3 DB - PRIME DP - Unbound Medicine ER -