Tags

Type your tag names separated by a space and hit enter

Activity of ceftaroline and comparators against pathogens isolated from skin and soft tissue infections in Latin America - results of AWARE surveillance 2012.
Braz J Infect Dis. 2015 Nov-Dec; 19(6):596-603.BJ

Abstract

As part of the Assessing Worldwide Antimicrobial Resistance Evaluation (AWARE) surveillance program in 2012 the in vitro activity of ceftaroline and relevant comparator antimicrobials was evaluated in six Latin American countries (Argentina, Brazil, Chile, Colombia, Mexico and Venezuela) against pathogens isolated from patients with hospital associated skin and soft tissue infections (SSTIs). The study documented that ceftaroline was highly active (MIC90 0.25mg/L/% susceptible 100%) against methicillin-susceptible Staphylococcus aureus, methicillin-resistant S. aureus (MIC90 2mg/L/% susceptible 83.3%) and β-hemolytic streptococci (MIC90 0.008-0.015mg/L/% susceptible 100%). The activity of ceftaroline against selected species of Enterobacteriaceae was dependent upon the presence or absence of extended-spectrum β-lactamases (ESBLs). Against ESBL screen-negative Escherichia coli, Klebsiella pneumoniae, and Klebsiella oxytoca the MIC90 and percent susceptible for ceftaroline were (0.5mg/L/94.1%), (0.5mg/L/99.0%) and (0.5mg/L/91.5%), respectively. Ceftaroline demonstrated potent activity against a recent collection of pathogens associated with SSTI in six Latin American countries in 2012.

Authors+Show Affiliations

International Health Management Associates Inc., Schaumburg, USA.International Health Management Associates Inc., Schaumburg, USA. Electronic address: dbiedenbach@ihmainc.com.International Health Management Associates Inc., Schaumburg, USA.AstraZeneca Pharmaceuticals, Waltham, USA.AstraZeneca Pharmaceuticals, Waltham, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26481631

Citation

Hoban, Daryl, et al. "Activity of Ceftaroline and Comparators Against Pathogens Isolated From Skin and Soft Tissue Infections in Latin America - Results of AWARE Surveillance 2012." The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases, vol. 19, no. 6, 2015, pp. 596-603.
Hoban D, Biedenbach D, Sahm D, et al. Activity of ceftaroline and comparators against pathogens isolated from skin and soft tissue infections in Latin America - results of AWARE surveillance 2012. Braz J Infect Dis. 2015;19(6):596-603.
Hoban, D., Biedenbach, D., Sahm, D., Reiszner, E., & Iaconis, J. (2015). Activity of ceftaroline and comparators against pathogens isolated from skin and soft tissue infections in Latin America - results of AWARE surveillance 2012. The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases, 19(6), 596-603. https://doi.org/10.1016/j.bjid.2015.08.011
Hoban D, et al. Activity of Ceftaroline and Comparators Against Pathogens Isolated From Skin and Soft Tissue Infections in Latin America - Results of AWARE Surveillance 2012. Braz J Infect Dis. 2015 Nov-Dec;19(6):596-603. PubMed PMID: 26481631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activity of ceftaroline and comparators against pathogens isolated from skin and soft tissue infections in Latin America - results of AWARE surveillance 2012. AU - Hoban,Daryl, AU - Biedenbach,Douglas, AU - Sahm,Daniel, AU - Reiszner,Edina, AU - Iaconis,Joseph, Y1 - 2015/10/16/ PY - 2015/07/10/received PY - 2015/08/06/revised PY - 2015/08/08/accepted PY - 2015/10/21/entrez PY - 2015/10/21/pubmed PY - 2016/5/24/medline KW - Ceftaroline KW - Latin America KW - Skin pathogens SP - 596 EP - 603 JF - The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases JO - Braz J Infect Dis VL - 19 IS - 6 N2 - As part of the Assessing Worldwide Antimicrobial Resistance Evaluation (AWARE) surveillance program in 2012 the in vitro activity of ceftaroline and relevant comparator antimicrobials was evaluated in six Latin American countries (Argentina, Brazil, Chile, Colombia, Mexico and Venezuela) against pathogens isolated from patients with hospital associated skin and soft tissue infections (SSTIs). The study documented that ceftaroline was highly active (MIC90 0.25mg/L/% susceptible 100%) against methicillin-susceptible Staphylococcus aureus, methicillin-resistant S. aureus (MIC90 2mg/L/% susceptible 83.3%) and β-hemolytic streptococci (MIC90 0.008-0.015mg/L/% susceptible 100%). The activity of ceftaroline against selected species of Enterobacteriaceae was dependent upon the presence or absence of extended-spectrum β-lactamases (ESBLs). Against ESBL screen-negative Escherichia coli, Klebsiella pneumoniae, and Klebsiella oxytoca the MIC90 and percent susceptible for ceftaroline were (0.5mg/L/94.1%), (0.5mg/L/99.0%) and (0.5mg/L/91.5%), respectively. Ceftaroline demonstrated potent activity against a recent collection of pathogens associated with SSTI in six Latin American countries in 2012. SN - 1678-4391 UR - https://www.unboundmedicine.com/medline/citation/26481631/Activity_of_ceftaroline_and_comparators_against_pathogens_isolated_from_skin_and_soft_tissue_infections_in_Latin_America___results_of_AWARE_surveillance_2012_ DB - PRIME DP - Unbound Medicine ER -