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Amount and distribution of dietary protein affects clinical response to levodopa in Parkinson's disease.
Neurology. 1989 Apr; 39(4):552-6.Neur

Abstract

Reducing dietary protein improves the effectiveness of levodopa (LD) but the most effective distribution of a low-protein diet (0.8 g/kg) is unclear. We compared a 1.6 g/kg protein diet, a 0.8 g/kg diet with protein evenly distributed between meals, and a 0.8 g/kg diet with protein restricted to the evening meal in 5 parkinsonian patients with motor fluctuations. We monitored clinical response, plasma LD, and plasma large amino acids (LNAAs) hourly throughout the day. Mean "on" times were 51% (1.6 g/kg diet), 67% (0.8 g/kg evenly distributed), and 77% (0.8 g/kg restricted). Hourly averages of plasma LD did not differ between the diets. The mean plasma LNAAs were 732 nmol/ml (1.6 g/kg diet), 640 (0.8 g/kg distributed), and 542 (0.8 g/kg restricted), and the diurnal pattern reflected the distribution of protein intake. In conclusion, the amount and distribution of dietary protein affect clinical response to LD. These effects are not related to LD absorption but are explained by the variation in plasma LNAAs.

Authors+Show Affiliations

Department of Neurology, Oregon Health Sciences University, Portland 97201.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2648188

Citation

Carter, J H., et al. "Amount and Distribution of Dietary Protein Affects Clinical Response to Levodopa in Parkinson's Disease." Neurology, vol. 39, no. 4, 1989, pp. 552-6.
Carter JH, Nutt JG, Woodward WR, et al. Amount and distribution of dietary protein affects clinical response to levodopa in Parkinson's disease. Neurology. 1989;39(4):552-6.
Carter, J. H., Nutt, J. G., Woodward, W. R., Hatcher, L. F., & Trotman, T. L. (1989). Amount and distribution of dietary protein affects clinical response to levodopa in Parkinson's disease. Neurology, 39(4), 552-6.
Carter JH, et al. Amount and Distribution of Dietary Protein Affects Clinical Response to Levodopa in Parkinson's Disease. Neurology. 1989;39(4):552-6. PubMed PMID: 2648188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amount and distribution of dietary protein affects clinical response to levodopa in Parkinson's disease. AU - Carter,J H, AU - Nutt,J G, AU - Woodward,W R, AU - Hatcher,L F, AU - Trotman,T L, PY - 1989/4/1/pubmed PY - 1989/4/1/medline PY - 1989/4/1/entrez SP - 552 EP - 6 JF - Neurology JO - Neurology VL - 39 IS - 4 N2 - Reducing dietary protein improves the effectiveness of levodopa (LD) but the most effective distribution of a low-protein diet (0.8 g/kg) is unclear. We compared a 1.6 g/kg protein diet, a 0.8 g/kg diet with protein evenly distributed between meals, and a 0.8 g/kg diet with protein restricted to the evening meal in 5 parkinsonian patients with motor fluctuations. We monitored clinical response, plasma LD, and plasma large amino acids (LNAAs) hourly throughout the day. Mean "on" times were 51% (1.6 g/kg diet), 67% (0.8 g/kg evenly distributed), and 77% (0.8 g/kg restricted). Hourly averages of plasma LD did not differ between the diets. The mean plasma LNAAs were 732 nmol/ml (1.6 g/kg diet), 640 (0.8 g/kg distributed), and 542 (0.8 g/kg restricted), and the diurnal pattern reflected the distribution of protein intake. In conclusion, the amount and distribution of dietary protein affect clinical response to LD. These effects are not related to LD absorption but are explained by the variation in plasma LNAAs. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/2648188/Amount_and_distribution_of_dietary_protein_affects_clinical_response_to_levodopa_in_Parkinson's_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2648188.ui DB - PRIME DP - Unbound Medicine ER -