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Comparison of serum and urine lead levels in opium addicts with healthy control group.
Hum Exp Toxicol 2016; 35(8):861-5HE

Abstract

CONTEXT

Lead-contaminated opium is one of the new sources of lead exposure in our region. As far as the literature review is concerned, there are limited comparative studies about comparison of blood lead level (BLL) in addict patients with healthy controls.

OBJECTIVE

We aimed to compare BLL and urine lead level (ULL) between opium addicts with the healthy control group.

MATERIALS AND METHODS

Forty opium addict subjects (mean age: 43 ± 10 years) as the patient group and 40 healthy subjects (mean age: 41 ± 9 years) as the control group participated. Three milliliter of whole blood and urine was obtained from both groups and lead level was assessed using atomic absorption spectrophotometry.

RESULTS

The mean value of BLL in patient group was 7.14 ± 1.41 mcg/dL and that in the healthy control group was 5.42 ± 1.46 mcg/dL. The mean value of ULL was 2.62 ± 0.83 mcg/dL in the patient group and 2.50 ± 0.76 mcg/dL in the healthy control group.BLL was different in the two groups (p < 0.001), but ULL was not (p = 0.5). There was a significant correlation between BLL with duration of opium addiction in the patient group (r = -0.403, p = 0.01). BLL and ULL were significantly correlated in controls (r = 0.436, p = 0.005) and not in patients.

DISCUSSION AND CONCLUSION

It was observed that the BLL in opium addicts was significantly higher than that in the healthy control group. This can be due to use of adulterated opium with lead. Therefore, screening of blood lead concentration is helpful for opium-addict patients especially with nonspecific symptoms.

Authors+Show Affiliations

Department of Psychiatry, Resident of Psychiatry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Community Medicine, Resident of Community Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Addiction Research Centre, Imam Reza (p) Hospital, Mashhad University of Medical Sciences, Mashhad, Iran BC Centre for Disease Control, Vancouver, Canada afsharir@mums.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26482096

Citation

Khatibi-Moghadam, H, et al. "Comparison of Serum and Urine Lead Levels in Opium Addicts With Healthy Control Group." Human & Experimental Toxicology, vol. 35, no. 8, 2016, pp. 861-5.
Khatibi-Moghadam H, Khadem-Rezaiyan M, Afshari R. Comparison of serum and urine lead levels in opium addicts with healthy control group. Hum Exp Toxicol. 2016;35(8):861-5.
Khatibi-Moghadam, H., Khadem-Rezaiyan, M., & Afshari, R. (2016). Comparison of serum and urine lead levels in opium addicts with healthy control group. Human & Experimental Toxicology, 35(8), pp. 861-5. doi:10.1177/0960327115607947.
Khatibi-Moghadam H, Khadem-Rezaiyan M, Afshari R. Comparison of Serum and Urine Lead Levels in Opium Addicts With Healthy Control Group. Hum Exp Toxicol. 2016;35(8):861-5. PubMed PMID: 26482096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of serum and urine lead levels in opium addicts with healthy control group. AU - Khatibi-Moghadam,H, AU - Khadem-Rezaiyan,M, AU - Afshari,R, Y1 - 2015/10/19/ PY - 2015/10/21/entrez PY - 2015/10/21/pubmed PY - 2017/2/10/medline KW - Lead KW - addiction KW - poisoning SP - 861 EP - 5 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 35 IS - 8 N2 - CONTEXT: Lead-contaminated opium is one of the new sources of lead exposure in our region. As far as the literature review is concerned, there are limited comparative studies about comparison of blood lead level (BLL) in addict patients with healthy controls. OBJECTIVE: We aimed to compare BLL and urine lead level (ULL) between opium addicts with the healthy control group. MATERIALS AND METHODS: Forty opium addict subjects (mean age: 43 ± 10 years) as the patient group and 40 healthy subjects (mean age: 41 ± 9 years) as the control group participated. Three milliliter of whole blood and urine was obtained from both groups and lead level was assessed using atomic absorption spectrophotometry. RESULTS: The mean value of BLL in patient group was 7.14 ± 1.41 mcg/dL and that in the healthy control group was 5.42 ± 1.46 mcg/dL. The mean value of ULL was 2.62 ± 0.83 mcg/dL in the patient group and 2.50 ± 0.76 mcg/dL in the healthy control group.BLL was different in the two groups (p < 0.001), but ULL was not (p = 0.5). There was a significant correlation between BLL with duration of opium addiction in the patient group (r = -0.403, p = 0.01). BLL and ULL were significantly correlated in controls (r = 0.436, p = 0.005) and not in patients. DISCUSSION AND CONCLUSION: It was observed that the BLL in opium addicts was significantly higher than that in the healthy control group. This can be due to use of adulterated opium with lead. Therefore, screening of blood lead concentration is helpful for opium-addict patients especially with nonspecific symptoms. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/26482096/Comparison_of_serum_and_urine_lead_levels_in_opium_addicts_with_healthy_control_group_ L2 - http://journals.sagepub.com/doi/full/10.1177/0960327115607947?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -