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Antinociceptive and neuropharmacological activities of methanol extract of Phoenix sylvestris fruit pulp.
Front Pharmacol 2015; 6:212FP

Abstract

Fruits of Phoenix sylvestris Roxb. (Arecaceae) are used to treat back pain, toothache, headache, arthritis, nervous debility and as sedative. The aim of this study was to evaluate the antinociceptive and neuropharmacological activities of methanol extract of P. sylvestris fruit pulp (MEPS). The antinociceptive activity of MEPS was evaluated by heat-induced (hot plate, tail immersion test) and chemical-induced pain models (acetic acid-induced writhing, formalin-induced nociception, glutamate-induced nociception and paw edema test). The effect of MEPS on central nervous system (CNS) was studied using hole cross test, open field test, sodium thiopental-induced sleeping time and elevated plus maze test. MEPS showed strong, significant and dose-dependent antinociceptive activity in all heat-induced and chemical-induced pain models at all experimental doses. Involvement of opioid receptor mediated analgesia was evident from the reversal of analgesic effect by naloxone. MEPS also showed reduced locomotor activity in both hole cross and open field tests. The increase in sleeping time in sodium thiopental-induced sleeping test and anxiolytic activity in elevated plus maze test were also significant. So, it is evident that MEPS possesses strong central and peripheral antinociceptive activity as well as CNS depressant, sedative and anxiolytic activity. The results justify the ethnomedicinal use of P. sylvestris fruit in different painful conditions and CNS disorders.

Authors+Show Affiliations

Department of Pharmacy, Stamford University Bangladesh Dhaka, Bangladesh.Department of Pharmacy, Primeasia University Dhaka, Bangladesh.Department of Pharmacy, Stamford University Bangladesh Dhaka, Bangladesh.Department of Pharmacy, Stamford University Bangladesh Dhaka, Bangladesh.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26483687

Citation

Shajib, Md Shafiullah, et al. "Antinociceptive and Neuropharmacological Activities of Methanol Extract of Phoenix Sylvestris Fruit Pulp." Frontiers in Pharmacology, vol. 6, 2015, p. 212.
Shajib MS, Akter S, Ahmed T, et al. Antinociceptive and neuropharmacological activities of methanol extract of Phoenix sylvestris fruit pulp. Front Pharmacol. 2015;6:212.
Shajib, M. S., Akter, S., Ahmed, T., & Imam, M. Z. (2015). Antinociceptive and neuropharmacological activities of methanol extract of Phoenix sylvestris fruit pulp. Frontiers in Pharmacology, 6, p. 212. doi:10.3389/fphar.2015.00212.
Shajib MS, et al. Antinociceptive and Neuropharmacological Activities of Methanol Extract of Phoenix Sylvestris Fruit Pulp. Front Pharmacol. 2015;6:212. PubMed PMID: 26483687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and neuropharmacological activities of methanol extract of Phoenix sylvestris fruit pulp. AU - Shajib,Md Shafiullah, AU - Akter,Saleha, AU - Ahmed,Tajnin, AU - Imam,Mohammad Zafar, Y1 - 2015/10/02/ PY - 2015/07/21/received PY - 2015/09/11/accepted PY - 2015/10/21/entrez PY - 2015/10/21/pubmed PY - 2015/10/21/medline KW - Arecaceae KW - CNS depressant KW - Phoenix sylvestris Roxb. KW - antinociceptive KW - anxiolytic KW - ethnomedicine KW - sedative SP - 212 EP - 212 JF - Frontiers in pharmacology JO - Front Pharmacol VL - 6 N2 - Fruits of Phoenix sylvestris Roxb. (Arecaceae) are used to treat back pain, toothache, headache, arthritis, nervous debility and as sedative. The aim of this study was to evaluate the antinociceptive and neuropharmacological activities of methanol extract of P. sylvestris fruit pulp (MEPS). The antinociceptive activity of MEPS was evaluated by heat-induced (hot plate, tail immersion test) and chemical-induced pain models (acetic acid-induced writhing, formalin-induced nociception, glutamate-induced nociception and paw edema test). The effect of MEPS on central nervous system (CNS) was studied using hole cross test, open field test, sodium thiopental-induced sleeping time and elevated plus maze test. MEPS showed strong, significant and dose-dependent antinociceptive activity in all heat-induced and chemical-induced pain models at all experimental doses. Involvement of opioid receptor mediated analgesia was evident from the reversal of analgesic effect by naloxone. MEPS also showed reduced locomotor activity in both hole cross and open field tests. The increase in sleeping time in sodium thiopental-induced sleeping test and anxiolytic activity in elevated plus maze test were also significant. So, it is evident that MEPS possesses strong central and peripheral antinociceptive activity as well as CNS depressant, sedative and anxiolytic activity. The results justify the ethnomedicinal use of P. sylvestris fruit in different painful conditions and CNS disorders. SN - 1663-9812 UR - https://www.unboundmedicine.com/medline/citation/26483687/Antinociceptive_and_neuropharmacological_activities_of_methanol_extract_of_Phoenix_sylvestris_fruit_pulp_ L2 - https://dx.doi.org/10.3389/fphar.2015.00212 DB - PRIME DP - Unbound Medicine ER -