Citation
Feikin, Daniel R., et al. "Association of Higher MERS-CoV Virus Load With Severe Disease and Death, Saudi Arabia, 2014." Emerging Infectious Diseases, vol. 21, no. 11, 2015, pp. 2029-35.
Feikin DR, Alraddadi B, Qutub M, et al. Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014. Emerg Infect Dis. 2015;21(11):2029-35.
Feikin, D. R., Alraddadi, B., Qutub, M., Shabouni, O., Curns, A., Oboho, I. K., Tomczyk, S. M., Wolff, B., Watson, J. T., & Madani, T. A. (2015). Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014. Emerging Infectious Diseases, 21(11), 2029-35. https://doi.org/10.3201/eid2111.150764
Feikin DR, et al. Association of Higher MERS-CoV Virus Load With Severe Disease and Death, Saudi Arabia, 2014. Emerg Infect Dis. 2015;21(11):2029-35. PubMed PMID: 26488195.
TY - JOUR
T1 - Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014.
AU - Feikin,Daniel R,
AU - Alraddadi,Basem,
AU - Qutub,Mohammed,
AU - Shabouni,Omaima,
AU - Curns,Aaron,
AU - Oboho,Ikwo K,
AU - Tomczyk,Sara M,
AU - Wolff,Bernard,
AU - Watson,John T,
AU - Madani,Tariq A,
PY - 2015/10/22/entrez
PY - 2015/10/22/pubmed
PY - 2016/5/18/medline
KW - MERS-CoV
KW - Middle East respiratory syndrome coronavirus
KW - Saudi Arabia
KW - virus load
KW - viruses
KW - zoonoses
SP - 2029
EP - 35
JF - Emerging infectious diseases
JO - Emerg Infect Dis
VL - 21
IS - 11
N2 - Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (Ct) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median Ct of 31.0 for the upstream of the E gene target for 41 (40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p=0.0087). In multivariable regression analyses, risk factors for death were age>60 years), underlying illness, and decreasing Ct for each 1-point decrease in Ct). Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.
SN - 1080-6059
UR - https://www.unboundmedicine.com/medline/citation/26488195/full_citation
L2 - https://doi.org/10.3201/eid2111.150764
DB - PRIME
DP - Unbound Medicine
ER -