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Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids.

Abstract

The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, and arachidonic acid increased during treatment with evening primrose oil. During olive oil treatment the serum concentration of eicosapentaenoic acid decreased and those of high density lipoprotein-cholesterol and apolipoprotein A-I increased slightly. The decrease in serum eicosapentaenoic acid and the increase in arachidonic acid concentrations induced by evening primrose oil may not be favourable effects in patients with rheumatoid arthritis in the light of the roles of these fatty acids as precursors of eicosanoids.

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  • Authors+Show Affiliations

    ,

    Rheumatism Foundation Hospital, Heinola, Finland.

    , , ,

    Source

    Annals of the rheumatic diseases 48:2 1989 Feb pg 124-7

    MeSH

    Anti-Inflammatory Agents, Non-Steroidal
    Arthritis, Rheumatoid
    Clinical Trials as Topic
    Dietary Fats, Unsaturated
    Double-Blind Method
    Fatty Acids
    Fatty Acids, Essential
    Humans
    Linoleic Acids
    Lipids
    Middle Aged
    Olive Oil
    Plant Oils
    Random Allocation
    gamma-Linolenic Acid

    Pub Type(s)

    Clinical Trial
    Controlled Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    2649022

    Citation

    Jäntti, J, et al. "Evening Primrose Oil in Rheumatoid Arthritis: Changes in Serum Lipids and Fatty Acids." Annals of the Rheumatic Diseases, vol. 48, no. 2, 1989, pp. 124-7.
    Jäntti J, Nikkari T, Solakivi T, et al. Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids. Ann Rheum Dis. 1989;48(2):124-7.
    Jäntti, J., Nikkari, T., Solakivi, T., Vapaatalo, H., & Isomäki, H. (1989). Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids. Annals of the Rheumatic Diseases, 48(2), pp. 124-7.
    Jäntti J, et al. Evening Primrose Oil in Rheumatoid Arthritis: Changes in Serum Lipids and Fatty Acids. Ann Rheum Dis. 1989;48(2):124-7. PubMed PMID: 2649022.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids. AU - Jäntti,J, AU - Nikkari,T, AU - Solakivi,T, AU - Vapaatalo,H, AU - Isomäki,H, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 124 EP - 7 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 48 IS - 2 N2 - The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, and arachidonic acid increased during treatment with evening primrose oil. During olive oil treatment the serum concentration of eicosapentaenoic acid decreased and those of high density lipoprotein-cholesterol and apolipoprotein A-I increased slightly. The decrease in serum eicosapentaenoic acid and the increase in arachidonic acid concentrations induced by evening primrose oil may not be favourable effects in patients with rheumatoid arthritis in the light of the roles of these fatty acids as precursors of eicosanoids. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/2649022/Evening_primrose_oil_in_rheumatoid_arthritis:_changes_in_serum_lipids_and_fatty_acids_ L2 - http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=2649022 DB - PRIME DP - Unbound Medicine ER -