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Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids.
Ann Rheum Dis 1989; 48(2):124-7AR

Abstract

The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, and arachidonic acid increased during treatment with evening primrose oil. During olive oil treatment the serum concentration of eicosapentaenoic acid decreased and those of high density lipoprotein-cholesterol and apolipoprotein A-I increased slightly. The decrease in serum eicosapentaenoic acid and the increase in arachidonic acid concentrations induced by evening primrose oil may not be favourable effects in patients with rheumatoid arthritis in the light of the roles of these fatty acids as precursors of eicosanoids.

Authors+Show Affiliations

Rheumatism Foundation Hospital, Heinola, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2649022

Citation

Jäntti, J, et al. "Evening Primrose Oil in Rheumatoid Arthritis: Changes in Serum Lipids and Fatty Acids." Annals of the Rheumatic Diseases, vol. 48, no. 2, 1989, pp. 124-7.
Jäntti J, Nikkari T, Solakivi T, et al. Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids. Ann Rheum Dis. 1989;48(2):124-7.
Jäntti, J., Nikkari, T., Solakivi, T., Vapaatalo, H., & Isomäki, H. (1989). Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids. Annals of the Rheumatic Diseases, 48(2), pp. 124-7.
Jäntti J, et al. Evening Primrose Oil in Rheumatoid Arthritis: Changes in Serum Lipids and Fatty Acids. Ann Rheum Dis. 1989;48(2):124-7. PubMed PMID: 2649022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids. AU - Jäntti,J, AU - Nikkari,T, AU - Solakivi,T, AU - Vapaatalo,H, AU - Isomäki,H, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 124 EP - 7 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 48 IS - 2 N2 - The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, and arachidonic acid increased during treatment with evening primrose oil. During olive oil treatment the serum concentration of eicosapentaenoic acid decreased and those of high density lipoprotein-cholesterol and apolipoprotein A-I increased slightly. The decrease in serum eicosapentaenoic acid and the increase in arachidonic acid concentrations induced by evening primrose oil may not be favourable effects in patients with rheumatoid arthritis in the light of the roles of these fatty acids as precursors of eicosanoids. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/2649022/Evening_primrose_oil_in_rheumatoid_arthritis:_changes_in_serum_lipids_and_fatty_acids_ L2 - http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=2649022 DB - PRIME DP - Unbound Medicine ER -