Tags

Type your tag names separated by a space and hit enter

The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies.
Eur J Nutr 2017; 56(1):247-260EJ

Abstract

PURPOSE

Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. As genetic variability of MTHFR influences folate status, it is important to ensure an adequate intake that overrides genetic effects but minimises any adverse effects. Our aim was to assess the influence of MTHFR genotype on folate status followed by response to supplementation.

METHODS

We performed a meta-analysis of ten folate intervention studies to assess the degree to which MTHFR C677T genotype influenced plasma homocysteine and serum folate levels as measures of folate status. We then examined response after supplementation at intake values up to the upper tolerable limit.

RESULTS

The MTHFR 677TT genotype was associated with higher plasma homocysteine (2.7 μmol/L, TT vs. CT/CC; 2.8 μmol/L, TT vs. CC) and lower serum folate (2.5 nmol/L, TT vs. CT/CC; 3.6 nmol/L, TT vs. CC). In two studies, the TT groups had mean plasma Hcy >15 μmol/L. Serum folate levels were >7 nmol/L for all genotype groups. After supplementation of 400 up to 1670 μg DFEs of folic acid or folic acid + fortified foods and/or natural food folates for a minimum of 4 weeks, there were no significant differences in plasma homocysteine levels; however, individuals with the TT genotype had a lower serum folate response to supplementation (7.2 nmol/L, TT vs. CT/CC; 8.7 nmol/L, TT vs. CC).

CONCLUSIONS

This meta-analysis confirms observations from observational and intervention studies that MTHFR TT genotype is associated with increased plasma homocysteine and lowered serum folate and less response to short-term supplementation. The results can be used for modelling and guiding personalised intake recommendations for the nutrient folate.

Authors+Show Affiliations

School of Medical Science, Griffith University, Gold Coast, Australia. n.colson@griffith.edu.au. Menzies Health Institute Queensland, Gold Coast, Australia. n.colson@griffith.edu.au.School of Medical Science, Griffith University, Gold Coast, Australia. Menzies Health Institute Queensland, Gold Coast, Australia.School of Medical Science, Griffith University, Gold Coast, Australia. Menzies Health Institute Queensland, Gold Coast, Australia.Menzies Health Institute Queensland, Gold Coast, Australia.School of Allied Health, Griffith University, Gold Coast, Australia.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

26497154

Citation

Colson, Natalie J., et al. "The Impact of MTHFR 677 C/T Genotypes On Folate Status Markers: a Meta-analysis of Folic Acid Intervention Studies." European Journal of Nutrition, vol. 56, no. 1, 2017, pp. 247-260.
Colson NJ, Naug HL, Nikbakht E, et al. The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies. Eur J Nutr. 2017;56(1):247-260.
Colson, N. J., Naug, H. L., Nikbakht, E., Zhang, P., & McCormack, J. (2017). The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies. European Journal of Nutrition, 56(1), pp. 247-260. doi:10.1007/s00394-015-1076-x.
Colson NJ, et al. The Impact of MTHFR 677 C/T Genotypes On Folate Status Markers: a Meta-analysis of Folic Acid Intervention Studies. Eur J Nutr. 2017;56(1):247-260. PubMed PMID: 26497154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies. AU - Colson,Natalie J, AU - Naug,Helen L, AU - Nikbakht,Elham, AU - Zhang,Ping, AU - McCormack,Joanna, Y1 - 2015/10/23/ PY - 2015/06/25/received PY - 2015/10/08/accepted PY - 2015/10/27/pubmed PY - 2017/4/5/medline PY - 2015/10/27/entrez KW - Folate KW - Folic acid KW - Homocysteine KW - MTHFR SP - 247 EP - 260 JF - European journal of nutrition JO - Eur J Nutr VL - 56 IS - 1 N2 - PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. As genetic variability of MTHFR influences folate status, it is important to ensure an adequate intake that overrides genetic effects but minimises any adverse effects. Our aim was to assess the influence of MTHFR genotype on folate status followed by response to supplementation. METHODS: We performed a meta-analysis of ten folate intervention studies to assess the degree to which MTHFR C677T genotype influenced plasma homocysteine and serum folate levels as measures of folate status. We then examined response after supplementation at intake values up to the upper tolerable limit. RESULTS: The MTHFR 677TT genotype was associated with higher plasma homocysteine (2.7 μmol/L, TT vs. CT/CC; 2.8 μmol/L, TT vs. CC) and lower serum folate (2.5 nmol/L, TT vs. CT/CC; 3.6 nmol/L, TT vs. CC). In two studies, the TT groups had mean plasma Hcy >15 μmol/L. Serum folate levels were >7 nmol/L for all genotype groups. After supplementation of 400 up to 1670 μg DFEs of folic acid or folic acid + fortified foods and/or natural food folates for a minimum of 4 weeks, there were no significant differences in plasma homocysteine levels; however, individuals with the TT genotype had a lower serum folate response to supplementation (7.2 nmol/L, TT vs. CT/CC; 8.7 nmol/L, TT vs. CC). CONCLUSIONS: This meta-analysis confirms observations from observational and intervention studies that MTHFR TT genotype is associated with increased plasma homocysteine and lowered serum folate and less response to short-term supplementation. The results can be used for modelling and guiding personalised intake recommendations for the nutrient folate. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/26497154/The_impact_of_MTHFR_677_C/T_genotypes_on_folate_status_markers:_a_meta_analysis_of_folic_acid_intervention_studies_ L2 - https://dx.doi.org/10.1007/s00394-015-1076-x DB - PRIME DP - Unbound Medicine ER -