Tags

Type your tag names separated by a space and hit enter

Serum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease.
Int Urol Nephrol. 2015 Dec; 47(12):1993-2001.IU

Abstract

BACKGROUND

Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin family best known as a novel and early marker of acute kidney injury (AKI). Recent data suggest that NGQueryAL is not only a marker of AKI, but also an important player in the vascular remodeling, atherosclerotic plaque stability and thrombus formation. We conducted this study to investigate the association of serum NGAL levels with fatal and composite (fatal and non-fatal) cardiovascular events (CVE) in a cohort of patients with stage 1-5 CKD.

METHODS

This was an observational cohort study in which serum NGAL was obtained from 298 CKD (stages 1-5) patients. Fatal and composite CVE were recorded for a median 41 months. We examined alteration of serum NGAL through CKD groups as well as association with inflammatory markers. We also performed a Cox regression analysis to determine the association of NGAL with predefined clinical outcomes.

RESULTS

The median value of NGAL was 50.5 ng/mL (IR 47.6-54.9 ng/mL), and higher NGAL values were recorded in diabetic patients. In a multiple linear regression model, including all univariate associates of NGAL, only log eGFR, log hs-CRP and log HDL cholesterol maintained an independent association with log NGAL. During the observational period, 30 patients died due to cardiovascular causes and 69 non-fatal CVE were registered. In the fully adjusted model, we observed a 2.08-fold increase in the risk of fatal CVE and a 1.50-fold increase in the risk of fatal and non-fatal CVE for each increment of 1 SD in log NGAL values.

CONCLUSIONS

This is the first study that shows that serum NGAL is associated with cardiovascular events (fatal and non-fatal) in patients with CKD, independently of traditional risk factors, renal function and inflammation.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, Sakarya University Medical School, Sakarya, Turkey. yalcinsolakmd@gmail.com.Department of Nephrology, Gülhane School of Medicine, Ankara, Turkey.Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.Department of Radiology, Gülhane School of Medicine, Ankara, Turkey.Department of Nephrology, Gülhane School of Medicine, Ankara, Turkey.Department of Biochemistry, Gülhane School of Medicine, Ankara, Turkey.Department of Nephrology, Gülhane School of Medicine, Ankara, Turkey.Department of Nephrology, Gülhane School of Medicine, Ankara, Turkey.Department of Extracorporeal Hemocorrection, National Scientific Medical Research Center, Astana, Kazakhstan.Department of Nephrology, Gülhane School of Medicine, Ankara, Turkey.Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.Department of Emergency, Gulhane School of Medicine, Ankara, Turkey.Department of Nephrology, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey.Division of Nephrology, Department of Internal Medicine, Selcuk University School of Medicine, Konya, Turkey.Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26498629

Citation

Solak, Yalcin, et al. "Serum Neutrophil Gelatinase-associated Lipocalin Is Associated With Cardiovascular Events in Patients With Chronic Kidney Disease." International Urology and Nephrology, vol. 47, no. 12, 2015, pp. 1993-2001.
Solak Y, Yilmaz MI, Siriopol D, et al. Serum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol. 2015;47(12):1993-2001.
Solak, Y., Yilmaz, M. I., Siriopol, D., Saglam, M., Unal, H. U., Yaman, H., Gok, M., Cetinkaya, H., Gaipov, A., Eyileten, T., Sari, S., Yildirim, A. O., Tonbul, H. Z., Turk, S., Covic, A., & Kanbay, M. (2015). Serum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease. International Urology and Nephrology, 47(12), 1993-2001. https://doi.org/10.1007/s11255-015-1136-4
Solak Y, et al. Serum Neutrophil Gelatinase-associated Lipocalin Is Associated With Cardiovascular Events in Patients With Chronic Kidney Disease. Int Urol Nephrol. 2015;47(12):1993-2001. PubMed PMID: 26498629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease. AU - Solak,Yalcin, AU - Yilmaz,Mahmut Ilker, AU - Siriopol,Dimitrie, AU - Saglam,Mutlu, AU - Unal,Hilmi Umut, AU - Yaman,Halil, AU - Gok,Mahmut, AU - Cetinkaya,Hakki, AU - Gaipov,Abduzhappar, AU - Eyileten,Tayfun, AU - Sari,Sebahattin, AU - Yildirim,Ali Osman, AU - Tonbul,Halil Zeki, AU - Turk,Suleyman, AU - Covic,Adrian, AU - Kanbay,Mehmet, Y1 - 2015/10/26/ PY - 2015/06/19/received PY - 2015/10/09/accepted PY - 2015/10/27/entrez PY - 2015/10/27/pubmed PY - 2016/9/14/medline KW - Cardiovascular disease KW - Chronic kidney disease KW - Mortality KW - NGAL KW - Prediction SP - 1993 EP - 2001 JF - International urology and nephrology JO - Int Urol Nephrol VL - 47 IS - 12 N2 - BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin family best known as a novel and early marker of acute kidney injury (AKI). Recent data suggest that NGQueryAL is not only a marker of AKI, but also an important player in the vascular remodeling, atherosclerotic plaque stability and thrombus formation. We conducted this study to investigate the association of serum NGAL levels with fatal and composite (fatal and non-fatal) cardiovascular events (CVE) in a cohort of patients with stage 1-5 CKD. METHODS: This was an observational cohort study in which serum NGAL was obtained from 298 CKD (stages 1-5) patients. Fatal and composite CVE were recorded for a median 41 months. We examined alteration of serum NGAL through CKD groups as well as association with inflammatory markers. We also performed a Cox regression analysis to determine the association of NGAL with predefined clinical outcomes. RESULTS: The median value of NGAL was 50.5 ng/mL (IR 47.6-54.9 ng/mL), and higher NGAL values were recorded in diabetic patients. In a multiple linear regression model, including all univariate associates of NGAL, only log eGFR, log hs-CRP and log HDL cholesterol maintained an independent association with log NGAL. During the observational period, 30 patients died due to cardiovascular causes and 69 non-fatal CVE were registered. In the fully adjusted model, we observed a 2.08-fold increase in the risk of fatal CVE and a 1.50-fold increase in the risk of fatal and non-fatal CVE for each increment of 1 SD in log NGAL values. CONCLUSIONS: This is the first study that shows that serum NGAL is associated with cardiovascular events (fatal and non-fatal) in patients with CKD, independently of traditional risk factors, renal function and inflammation. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/26498629/Serum_neutrophil_gelatinase_associated_lipocalin_is_associated_with_cardiovascular_events_in_patients_with_chronic_kidney_disease_ L2 - https://doi.org/10.1007/s11255-015-1136-4 DB - PRIME DP - Unbound Medicine ER -