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Role of the Entero-Insular Axis in the Pathogenesis of Idiopathic Reactive Hypoglycemia: A Pilot Study.
J Clin Endocrinol Metab. 2015 Dec; 100(12):4441-6.JC

Abstract

CONTEXT

Idiopathic reactive hypoglycemia (IRH) is characterized by recurrent episodes of symptomatic hypoglycemia occurring within 4 hours after meals. The underlying mechanisms remain obscure.

OBJECTIVE

This study aimed to investigate the response of the glucoregulatory and gastrointestinal hormones to an oral glucose load (OGTT) in individuals with documented IRH.

DESIGN AND SETTING

This was a cross-sectional study composed of outpatients referred to "Federico II" University of Naples.

PATIENTS

We enrolled subjects with IRH documented by a mixed meal under ordinary life conditions and healthy subjects as controls.

MAIN OUTCOME MEASURE

We measured plasma glucose, insulin, glucagon-like peptide 1 (GLP-1), GIP, and glucagon response to a 75-g OGTT in cases and controls.

RESULTS

Ten IRH and eight control subjects were enrolled. During the OGTT, mean plasma glucose tended to be lower in IRH than in control subjects, reaching a statistically significant difference at 240 minutes (T240) (43 ± 1.6 vs 72 ± 0.3 mg/dL; P = .001). Accordingly, the insulin response was higher in IRH than in control subjects (P < .019) with a statistically significant difference (46%) at T90 (P = .045) and was associated with significantly lower glucagon levels in the late phase of the OGTT: at T120 (P = .031) and T180 (P = .048) in IRH than in control subjects. A greater GLP-1 response was found among IRH compared with control subjects (P = .005); GLP-1 peak was 2-fold higher in IRH individuals (9.77 ± 2.52 pmol/L) than in the control group (4.19 ± 0.53 pmol/L; P = .041). In the IRH group, GLP-1 peak inversely correlated with the nadir of plasma glucose (r = -0.66; P = .039). A multivariate analysis confirmed that GLP-1 peak independently predicted the plasma glucose nadir (β = -0.593; P = .026).

CONCLUSIONS

GLP-1 may play a significant role in the pathogenesis of idiopathic IRH.

Authors+Show Affiliations

Department of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.Department of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.Department of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.Department of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.Department of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.Department of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26502359

Citation

Lupoli, Roberta, et al. "Role of the Entero-Insular Axis in the Pathogenesis of Idiopathic Reactive Hypoglycemia: a Pilot Study." The Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 12, 2015, pp. 4441-6.
Lupoli R, Cotugno M, Griffo E, et al. Role of the Entero-Insular Axis in the Pathogenesis of Idiopathic Reactive Hypoglycemia: A Pilot Study. J Clin Endocrinol Metab. 2015;100(12):4441-6.
Lupoli, R., Cotugno, M., Griffo, E., Nosso, G., Riccardi, G., & Capaldo, B. (2015). Role of the Entero-Insular Axis in the Pathogenesis of Idiopathic Reactive Hypoglycemia: A Pilot Study. The Journal of Clinical Endocrinology and Metabolism, 100(12), 4441-6. https://doi.org/10.1210/jc.2015-3309
Lupoli R, et al. Role of the Entero-Insular Axis in the Pathogenesis of Idiopathic Reactive Hypoglycemia: a Pilot Study. J Clin Endocrinol Metab. 2015;100(12):4441-6. PubMed PMID: 26502359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the Entero-Insular Axis in the Pathogenesis of Idiopathic Reactive Hypoglycemia: A Pilot Study. AU - Lupoli,Roberta, AU - Cotugno,Mariella, AU - Griffo,Ettore, AU - Nosso,Gabriella, AU - Riccardi,Gabriele, AU - Capaldo,Brunella, Y1 - 2015/10/26/ PY - 2015/10/27/entrez PY - 2015/10/27/pubmed PY - 2016/4/20/medline SP - 4441 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 100 IS - 12 N2 - CONTEXT: Idiopathic reactive hypoglycemia (IRH) is characterized by recurrent episodes of symptomatic hypoglycemia occurring within 4 hours after meals. The underlying mechanisms remain obscure. OBJECTIVE: This study aimed to investigate the response of the glucoregulatory and gastrointestinal hormones to an oral glucose load (OGTT) in individuals with documented IRH. DESIGN AND SETTING: This was a cross-sectional study composed of outpatients referred to "Federico II" University of Naples. PATIENTS: We enrolled subjects with IRH documented by a mixed meal under ordinary life conditions and healthy subjects as controls. MAIN OUTCOME MEASURE: We measured plasma glucose, insulin, glucagon-like peptide 1 (GLP-1), GIP, and glucagon response to a 75-g OGTT in cases and controls. RESULTS: Ten IRH and eight control subjects were enrolled. During the OGTT, mean plasma glucose tended to be lower in IRH than in control subjects, reaching a statistically significant difference at 240 minutes (T240) (43 ± 1.6 vs 72 ± 0.3 mg/dL; P = .001). Accordingly, the insulin response was higher in IRH than in control subjects (P < .019) with a statistically significant difference (46%) at T90 (P = .045) and was associated with significantly lower glucagon levels in the late phase of the OGTT: at T120 (P = .031) and T180 (P = .048) in IRH than in control subjects. A greater GLP-1 response was found among IRH compared with control subjects (P = .005); GLP-1 peak was 2-fold higher in IRH individuals (9.77 ± 2.52 pmol/L) than in the control group (4.19 ± 0.53 pmol/L; P = .041). In the IRH group, GLP-1 peak inversely correlated with the nadir of plasma glucose (r = -0.66; P = .039). A multivariate analysis confirmed that GLP-1 peak independently predicted the plasma glucose nadir (β = -0.593; P = .026). CONCLUSIONS: GLP-1 may play a significant role in the pathogenesis of idiopathic IRH. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/26502359/Role_of_the_Entero_Insular_Axis_in_the_Pathogenesis_of_Idiopathic_Reactive_Hypoglycemia:_A_Pilot_Study_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2015-3309 DB - PRIME DP - Unbound Medicine ER -