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The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan-Anseong) cohort.
Int J Chron Obstruct Pulmon Dis. 2015; 10:2159-68.IJ

Abstract

BACKGROUND

Dietary antioxidants have been suggested to have protective role against chronic obstructive pulmonary disease (COPD), but few prospective studies examined this relationship. The prospective study was conducted to evaluate the effect of dietary antioxidants on COPD risk and lung function in the Korean population.

METHODS

The data were collected from the community-based Korean Genome Epidemiology Study (KoGES) cohort. To diagnose COPD, forced expiratory volume (FEV1) and forced vital capacity (FVC) were measured by spirometry. The dietary intake of antioxidant vitamins was estimated from validated Food-Frequency Questionnaire. For the analysis, 325 COPD patients and 6,781 at risk subjects were selected from the cohort of 10,038 subjects. Multiple logistic regression models were used to examine the odds ratio (OR) after adjusting for age, sex, marital status, income, history of asthma, history of tuberculosis, and smoking.

RESULTS

The risk of COPD was positively associated with aging, low education, low household income, lower body mass index, and cigarette smoking. The risk of COPD decreased with increase in the dietary vitamin C (ORQ1 vs Q5=0.66, P trend=0.03) and vitamin E (ORQ1 vs Q5=0.56, P trend=0.05) intake, predominantly, in men (P trend=0.01 and 0.05 for vitamins C and E, respectively). In addition, the lung function was significantly improved with increase in vitamins C (FEV1, P=0.04; FVC, P=0.03) and E (FEV1, P=0.03; FVC, P=0.04) intake. No statistically significant interactions were observed between smoking and vitamin C or E intake in relation to COPD risk among men.

CONCLUSION

Our results suggest the independent beneficial effect of antioxidants, particularly vitamins C and E, on COPD risk and lung function in men.

Authors+Show Affiliations

Department of Preventive Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea ; BIT Medical Convergence Graduate Program, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea.Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea ; Environmental Health Center, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea.Department of Preventive Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea ; BIT Medical Convergence Graduate Program, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea ; Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26504380

Citation

Joshi, Pankaj, et al. "The Effect of Dietary Antioxidant On the COPD Risk: the Community-based KoGES (Ansan-Anseong) Cohort." International Journal of Chronic Obstructive Pulmonary Disease, vol. 10, 2015, pp. 2159-68.
Joshi P, Kim WJ, Lee SA. The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan-Anseong) cohort. Int J Chron Obstruct Pulmon Dis. 2015;10:2159-68.
Joshi, P., Kim, W. J., & Lee, S. A. (2015). The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan-Anseong) cohort. International Journal of Chronic Obstructive Pulmonary Disease, 10, 2159-68. https://doi.org/10.2147/COPD.S91877
Joshi P, Kim WJ, Lee SA. The Effect of Dietary Antioxidant On the COPD Risk: the Community-based KoGES (Ansan-Anseong) Cohort. Int J Chron Obstruct Pulmon Dis. 2015;10:2159-68. PubMed PMID: 26504380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan-Anseong) cohort. AU - Joshi,Pankaj, AU - Kim,Woo Jin, AU - Lee,Sang-Ah, Y1 - 2015/10/08/ PY - 2015/10/28/entrez PY - 2015/10/28/pubmed PY - 2016/7/12/medline KW - antioxidant vitamins intake KW - chronic obstructive pulmonary disease (COPD) KW - lung function KW - smoking KW - the combined effect of smoking and antioxidant vitamins SP - 2159 EP - 68 JF - International journal of chronic obstructive pulmonary disease JO - Int J Chron Obstruct Pulmon Dis VL - 10 N2 - BACKGROUND: Dietary antioxidants have been suggested to have protective role against chronic obstructive pulmonary disease (COPD), but few prospective studies examined this relationship. The prospective study was conducted to evaluate the effect of dietary antioxidants on COPD risk and lung function in the Korean population. METHODS: The data were collected from the community-based Korean Genome Epidemiology Study (KoGES) cohort. To diagnose COPD, forced expiratory volume (FEV1) and forced vital capacity (FVC) were measured by spirometry. The dietary intake of antioxidant vitamins was estimated from validated Food-Frequency Questionnaire. For the analysis, 325 COPD patients and 6,781 at risk subjects were selected from the cohort of 10,038 subjects. Multiple logistic regression models were used to examine the odds ratio (OR) after adjusting for age, sex, marital status, income, history of asthma, history of tuberculosis, and smoking. RESULTS: The risk of COPD was positively associated with aging, low education, low household income, lower body mass index, and cigarette smoking. The risk of COPD decreased with increase in the dietary vitamin C (ORQ1 vs Q5=0.66, P trend=0.03) and vitamin E (ORQ1 vs Q5=0.56, P trend=0.05) intake, predominantly, in men (P trend=0.01 and 0.05 for vitamins C and E, respectively). In addition, the lung function was significantly improved with increase in vitamins C (FEV1, P=0.04; FVC, P=0.03) and E (FEV1, P=0.03; FVC, P=0.04) intake. No statistically significant interactions were observed between smoking and vitamin C or E intake in relation to COPD risk among men. CONCLUSION: Our results suggest the independent beneficial effect of antioxidants, particularly vitamins C and E, on COPD risk and lung function in men. SN - 1178-2005 UR - https://www.unboundmedicine.com/medline/citation/26504380/The_effect_of_dietary_antioxidant_on_the_COPD_risk:_the_community_based_KoGES__Ansan_Anseong__cohort_ L2 - https://dx.doi.org/10.2147/COPD.S91877 DB - PRIME DP - Unbound Medicine ER -