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Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study.
Biomed Res Int. 2015; 2015:284154.BR

Abstract

BACKGROUND

Many women experience sexual dysfunction where there are orgasm disorders and sexual difficulties. Ashwagandha (Withania somnifera) is a herb known to improve the body's physical and psychological condition.

OBJECTIVE

The purpose of the study was to determine the efficacy and safety of a high-concentration ashwagandha root extract (HCARE) supplementation for improving sexual function in healthy females.

METHODS

In this pilot study, 50 study subjects were randomized to either (i) HCARE-treated group or (ii) placebo- (starch-) treated group. The subjects consumed either HCARE or placebo capsules of 300mg twice daily for 8 weeks. Sexual function was assessed using two psychometric scales, the Female Sexual Function Index (FSFI) Questionnaire and the Female Sexual Distress Scale (FSDS), and by the number of total and successful sexual encounters.

RESULTS

The analysis indicates that treatment with HCARE leads to significantly higher improvement, relative to placebo, in the FSFI Total score (p < 0.001), FSFI domain score for "arousal" (p < 0.001), "lubrication" (p < 0.001), "orgasm" (p = 0.004), and "satisfaction" (p < 0.001), and also FSDS score (p < 0.001) and the number of successful sexual encounters (p < 0.001) at the end of the treatment.

CONCLUSIONS

This study demonstrated that oral administration of HCARE may improve sexual function in healthy women. The present study is registered in the Clinical Trial Registry, Government of India, with a number CTRI/2015/07/006045.

Authors+Show Affiliations

Trupti Hospital and Santati Fertility Center, Cosmos Paradise, Pokhran Road 1, Link Road, Thane, Maharashtra 400 606, India.Department of Pharmacology, BVDU Dental College & Hospital, Sector 7, C.B.D., Belpada, Navi Mumbai, Maharashtra 400 614, India.Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, India.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26504795

Citation

Dongre, Swati, et al. "Efficacy and Safety of Ashwagandha (Withania Somnifera) Root Extract in Improving Sexual Function in Women: a Pilot Study." BioMed Research International, vol. 2015, 2015, p. 284154.
Dongre S, Langade D, Bhattacharyya S. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. Biomed Res Int. 2015;2015:284154.
Dongre, S., Langade, D., & Bhattacharyya, S. (2015). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. BioMed Research International, 2015, 284154. https://doi.org/10.1155/2015/284154
Dongre S, Langade D, Bhattacharyya S. Efficacy and Safety of Ashwagandha (Withania Somnifera) Root Extract in Improving Sexual Function in Women: a Pilot Study. Biomed Res Int. 2015;2015:284154. PubMed PMID: 26504795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. AU - Dongre,Swati, AU - Langade,Deepak, AU - Bhattacharyya,Sauvik, Y1 - 2015/10/04/ PY - 2015/06/22/received PY - 2015/08/27/revised PY - 2015/09/08/accepted PY - 2015/10/28/entrez PY - 2015/10/28/pubmed PY - 2016/8/18/medline SP - 284154 EP - 284154 JF - BioMed research international JO - Biomed Res Int VL - 2015 N2 - BACKGROUND: Many women experience sexual dysfunction where there are orgasm disorders and sexual difficulties. Ashwagandha (Withania somnifera) is a herb known to improve the body's physical and psychological condition. OBJECTIVE: The purpose of the study was to determine the efficacy and safety of a high-concentration ashwagandha root extract (HCARE) supplementation for improving sexual function in healthy females. METHODS: In this pilot study, 50 study subjects were randomized to either (i) HCARE-treated group or (ii) placebo- (starch-) treated group. The subjects consumed either HCARE or placebo capsules of 300mg twice daily for 8 weeks. Sexual function was assessed using two psychometric scales, the Female Sexual Function Index (FSFI) Questionnaire and the Female Sexual Distress Scale (FSDS), and by the number of total and successful sexual encounters. RESULTS: The analysis indicates that treatment with HCARE leads to significantly higher improvement, relative to placebo, in the FSFI Total score (p < 0.001), FSFI domain score for "arousal" (p < 0.001), "lubrication" (p < 0.001), "orgasm" (p = 0.004), and "satisfaction" (p < 0.001), and also FSDS score (p < 0.001) and the number of successful sexual encounters (p < 0.001) at the end of the treatment. CONCLUSIONS: This study demonstrated that oral administration of HCARE may improve sexual function in healthy women. The present study is registered in the Clinical Trial Registry, Government of India, with a number CTRI/2015/07/006045. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/26504795/Efficacy_and_Safety_of_Ashwagandha__Withania_somnifera__Root_Extract_in_Improving_Sexual_Function_in_Women:_A_Pilot_Study_ L2 - https://doi.org/10.1155/2015/284154 DB - PRIME DP - Unbound Medicine ER -