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Association of dietary and serum vitamin E with bone mineral density in middle-aged and elderly Chinese adults: a cross-sectional study.
Br J Nutr 2016; 115(1):113-20BJ

Abstract

Previous studies have suggested that vitamin E (VE) may affect bone health, but the findings have been inconclusive. We examined the relationship between VE status (in both diet and serum) and bone mineral density (BMD) among Chinese adults. This community-based study included 3203 adults (2178 women and 1025 men) aged 40-75 years from Guangzhou, People's Republic of China. General and dietary intake information were collected using structured questionnaire interviews. The serum α-tocopherol (TF) level was quantified by reversed-phase HPLC. The BMD of the whole body, the lumbar spine and left hip sites (total, neck, trochanter, intertrochanter and Ward's triangle) were measured using dual-energy X-ray absorptiometry. In women, the dietary intake of VE was significantly and positively associated with BMD at the lumbar spine, total hip, intertrochanter and femur neck sites after adjusting for covariates (P(trend): 0·001-0·017). Women in quartile 3 of VE intake typically had the highest BMD; the covariate-adjusted mean BMD were 2·5, 3·06, 3·41 and 3·54% higher, respectively, in quartile 3 (v. 1) at the four above-mentioned sites. Similar positive associations were observed between cholesterol-adjusted serum α-TF levels and BMD at each of the studied bone sites (P(trend): 0·001-0·022). The covariate-adjusted mean BMD were 1·24-4·83% greater in quartile 4 (v. 1) in women. However, no significant associations were seen between the VE levels (dietary or serum) and the BMD at any site in men. In conclusion, greater consumption and higher serum levels of VE are associated with greater BMD in Chinese women but not in Chinese men.

Authors+Show Affiliations

1Guangdong Provincial Key Laboratory of Food, Nutrition, and Health,School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong 510080,People's Republic of China.1Guangdong Provincial Key Laboratory of Food, Nutrition, and Health,School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong 510080,People's Republic of China.1Guangdong Provincial Key Laboratory of Food, Nutrition, and Health,School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong 510080,People's Republic of China.1Guangdong Provincial Key Laboratory of Food, Nutrition, and Health,School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong 510080,People's Republic of China.1Guangdong Provincial Key Laboratory of Food, Nutrition, and Health,School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong 510080,People's Republic of China.1Guangdong Provincial Key Laboratory of Food, Nutrition, and Health,School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong 510080,People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26507315

Citation

Shi, Wen-qi, et al. "Association of Dietary and Serum Vitamin E With Bone Mineral Density in Middle-aged and Elderly Chinese Adults: a Cross-sectional Study." The British Journal of Nutrition, vol. 115, no. 1, 2016, pp. 113-20.
Shi WQ, Liu J, Cao Y, et al. Association of dietary and serum vitamin E with bone mineral density in middle-aged and elderly Chinese adults: a cross-sectional study. Br J Nutr. 2016;115(1):113-20.
Shi, W. Q., Liu, J., Cao, Y., Zhu, Y. Y., Guan, K., & Chen, Y. M. (2016). Association of dietary and serum vitamin E with bone mineral density in middle-aged and elderly Chinese adults: a cross-sectional study. The British Journal of Nutrition, 115(1), pp. 113-20. doi:10.1017/S0007114515004134.
Shi WQ, et al. Association of Dietary and Serum Vitamin E With Bone Mineral Density in Middle-aged and Elderly Chinese Adults: a Cross-sectional Study. Br J Nutr. 2016 Jan 14;115(1):113-20. PubMed PMID: 26507315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of dietary and serum vitamin E with bone mineral density in middle-aged and elderly Chinese adults: a cross-sectional study. AU - Shi,Wen-qi, AU - Liu,Jun, AU - Cao,Yi, AU - Zhu,Ying-ying, AU - Guan,Ke, AU - Chen,Yu-ming, Y1 - 2015/10/28/ PY - 2015/10/29/entrez PY - 2015/10/29/pubmed PY - 2016/3/26/medline KW - BMD bone mineral density KW - Bone mineral density KW - Chinese KW - Cross-sectional studies KW - Dietary vitamin E KW - Serum α-tocopherol KW - TF tocopherol KW - VE vitamin E SP - 113 EP - 20 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 115 IS - 1 N2 - Previous studies have suggested that vitamin E (VE) may affect bone health, but the findings have been inconclusive. We examined the relationship between VE status (in both diet and serum) and bone mineral density (BMD) among Chinese adults. This community-based study included 3203 adults (2178 women and 1025 men) aged 40-75 years from Guangzhou, People's Republic of China. General and dietary intake information were collected using structured questionnaire interviews. The serum α-tocopherol (TF) level was quantified by reversed-phase HPLC. The BMD of the whole body, the lumbar spine and left hip sites (total, neck, trochanter, intertrochanter and Ward's triangle) were measured using dual-energy X-ray absorptiometry. In women, the dietary intake of VE was significantly and positively associated with BMD at the lumbar spine, total hip, intertrochanter and femur neck sites after adjusting for covariates (P(trend): 0·001-0·017). Women in quartile 3 of VE intake typically had the highest BMD; the covariate-adjusted mean BMD were 2·5, 3·06, 3·41 and 3·54% higher, respectively, in quartile 3 (v. 1) at the four above-mentioned sites. Similar positive associations were observed between cholesterol-adjusted serum α-TF levels and BMD at each of the studied bone sites (P(trend): 0·001-0·022). The covariate-adjusted mean BMD were 1·24-4·83% greater in quartile 4 (v. 1) in women. However, no significant associations were seen between the VE levels (dietary or serum) and the BMD at any site in men. In conclusion, greater consumption and higher serum levels of VE are associated with greater BMD in Chinese women but not in Chinese men. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26507315/Association_of_dietary_and_serum_vitamin_E_with_bone_mineral_density_in_middle_aged_and_elderly_Chinese_adults:_a_cross_sectional_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515004134/type/journal_article DB - PRIME DP - Unbound Medicine ER -