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Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Children and Adolescents.
J Pediatr Health Care. 2016 Jul-Aug; 30(4):347-58.JP

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease that is becoming increasingly recognized in the pediatric population. It may be the most common cause of treatable autoimmune encephalitis. The majority of cases of anti-NMDAR encephalitis are idiopathic in etiology, but a significant minority can be attributed to a paraneoplastic origin. Children with anti-NMDAR encephalitis initially present with a prodrome of neuropsychiatric symptoms, often with orofacial dyskinesias followed by progressively worsening seizures, agitation, and spasticity, which may result in severe neurologic deficits and even death. Definitive diagnosis requires detection of NMDAR antibodies in the cerebrospinal fluid. Optimal outcomes are associated with prompt removal of the tumor in paraneoplastic cases, as well as aggressive immunosuppressive therapy. Early detection is essential for increasing the chances for a good outcome. Close follow-up is required to screen for relapse and later onset tumor presentation. The nurse practitioner plays a major role in the research, screening, diagnosis, treatment, follow-up, and rehabilitation of a child or adolescent with anti-NMDAR encephalitis.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26507948

Citation

Scheer, Shelly, and Rita Marie John. "Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Children and Adolescents." Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners, vol. 30, no. 4, 2016, pp. 347-58.
Scheer S, John RM. Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Children and Adolescents. J Pediatr Health Care. 2016;30(4):347-58.
Scheer, S., & John, R. M. (2016). Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Children and Adolescents. Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners, 30(4), 347-58. https://doi.org/10.1016/j.pedhc.2015.09.004
Scheer S, John RM. Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Children and Adolescents. J Pediatr Health Care. 2016 Jul-Aug;30(4):347-58. PubMed PMID: 26507948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Children and Adolescents. AU - Scheer,Shelly, AU - John,Rita Marie, Y1 - 2015/10/21/ PY - 2015/07/01/received PY - 2015/09/15/revised PY - 2015/09/17/accepted PY - 2015/10/29/entrez PY - 2015/10/29/pubmed PY - 2018/1/4/medline KW - Anti–N-methyl-D-aspartate receptor KW - NMDA KW - NMDAR KW - anti-NMDA KW - encephalitis SP - 347 EP - 58 JF - Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners JO - J Pediatr Health Care VL - 30 IS - 4 N2 - Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease that is becoming increasingly recognized in the pediatric population. It may be the most common cause of treatable autoimmune encephalitis. The majority of cases of anti-NMDAR encephalitis are idiopathic in etiology, but a significant minority can be attributed to a paraneoplastic origin. Children with anti-NMDAR encephalitis initially present with a prodrome of neuropsychiatric symptoms, often with orofacial dyskinesias followed by progressively worsening seizures, agitation, and spasticity, which may result in severe neurologic deficits and even death. Definitive diagnosis requires detection of NMDAR antibodies in the cerebrospinal fluid. Optimal outcomes are associated with prompt removal of the tumor in paraneoplastic cases, as well as aggressive immunosuppressive therapy. Early detection is essential for increasing the chances for a good outcome. Close follow-up is required to screen for relapse and later onset tumor presentation. The nurse practitioner plays a major role in the research, screening, diagnosis, treatment, follow-up, and rehabilitation of a child or adolescent with anti-NMDAR encephalitis. SN - 1532-656X UR - https://www.unboundmedicine.com/medline/citation/26507948/Anti_N_Methyl_D_Aspartate_Receptor_Encephalitis_in_Children_and_Adolescents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5245(15)00303-X DB - PRIME DP - Unbound Medicine ER -