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Effects of Vegetarian Diets on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
J Am Heart Assoc 2015; 4(10):e002408JA

Abstract

BACKGROUND

Vegetarian diets exclude all animal flesh and are being widely adopted by an increasing number of people; however, effects on blood lipid concentrations remain unclear. This meta-analysis aimed to quantitatively assess the overall effects of vegetarian diets on blood lipids.

METHODS AND RESULTS

We searched PubMed, Scopus, Embase, ISI Web of Knowledge, and the Cochrane Library through March 2015. Studies were included if they described the effectiveness of vegetarian diets on blood lipids (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride). Weighted mean effect sizes were calculated for net changes by using a random-effects model. We performed subgroup and univariate meta-regression analyses to explore sources of heterogeneity. Eleven trials were included in the meta-analysis. Vegetarian diets significantly lowered blood concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, and the pooled estimated changes were -0.36 mmol/L (95% CI -0.55 to -0.17; P<0.001), -0.34 mmol/L (95% CI -0.57 to -0.11; P<0.001), -0.10 mmol/L (95% CI -0.14 to -0.06; P<0.001), and -0.30 mmol/L (95% CI -0.50 to -0.10; P=0.04), respectively. Vegetarian diets did not significantly affect blood triglyceride concentrations, with a pooled estimated mean difference of 0.04 mmol/L (95% CI -0.05 to 0.13; P=0.40).

CONCLUSIONS

This systematic review and meta-analysis provides evidence that vegetarian diets effectively lower blood concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol. Such diets could be a useful nonpharmaceutical means of managing dyslipidemia, especially hypercholesterolemia.

Authors+Show Affiliations

Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26508743

Citation

Wang, Fenglei, et al. "Effects of Vegetarian Diets On Blood Lipids: a Systematic Review and Meta-Analysis of Randomized Controlled Trials." Journal of the American Heart Association, vol. 4, no. 10, 2015, pp. e002408.
Wang F, Zheng J, Yang B, et al. Effects of Vegetarian Diets on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2015;4(10):e002408.
Wang, F., Zheng, J., Yang, B., Jiang, J., Fu, Y., & Li, D. (2015). Effects of Vegetarian Diets on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of the American Heart Association, 4(10), pp. e002408. doi:10.1161/JAHA.115.002408.
Wang F, et al. Effects of Vegetarian Diets On Blood Lipids: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2015 Oct 27;4(10):e002408. PubMed PMID: 26508743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Vegetarian Diets on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. AU - Wang,Fenglei, AU - Zheng,Jusheng, AU - Yang,Bo, AU - Jiang,Jiajing, AU - Fu,Yuanqing, AU - Li,Duo, Y1 - 2015/10/27/ PY - 2015/10/29/entrez PY - 2015/10/29/pubmed PY - 2016/7/9/medline KW - cholesterol KW - diet KW - lipoprotein lipids KW - triglyceride KW - vegetarian SP - e002408 EP - e002408 JF - Journal of the American Heart Association JO - J Am Heart Assoc VL - 4 IS - 10 N2 - BACKGROUND: Vegetarian diets exclude all animal flesh and are being widely adopted by an increasing number of people; however, effects on blood lipid concentrations remain unclear. This meta-analysis aimed to quantitatively assess the overall effects of vegetarian diets on blood lipids. METHODS AND RESULTS: We searched PubMed, Scopus, Embase, ISI Web of Knowledge, and the Cochrane Library through March 2015. Studies were included if they described the effectiveness of vegetarian diets on blood lipids (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride). Weighted mean effect sizes were calculated for net changes by using a random-effects model. We performed subgroup and univariate meta-regression analyses to explore sources of heterogeneity. Eleven trials were included in the meta-analysis. Vegetarian diets significantly lowered blood concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, and the pooled estimated changes were -0.36 mmol/L (95% CI -0.55 to -0.17; P<0.001), -0.34 mmol/L (95% CI -0.57 to -0.11; P<0.001), -0.10 mmol/L (95% CI -0.14 to -0.06; P<0.001), and -0.30 mmol/L (95% CI -0.50 to -0.10; P=0.04), respectively. Vegetarian diets did not significantly affect blood triglyceride concentrations, with a pooled estimated mean difference of 0.04 mmol/L (95% CI -0.05 to 0.13; P=0.40). CONCLUSIONS: This systematic review and meta-analysis provides evidence that vegetarian diets effectively lower blood concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol. Such diets could be a useful nonpharmaceutical means of managing dyslipidemia, especially hypercholesterolemia. SN - 2047-9980 UR - https://www.unboundmedicine.com/medline/citation/26508743/Effects_of_Vegetarian_Diets_on_Blood_Lipids:_A_Systematic_Review_and_Meta_Analysis_of_Randomized_Controlled_Trials_ L2 - http://www.ahajournals.org/doi/full/10.1161/JAHA.115.002408?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -