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Dental Anomalies as Late Adverse Effect among Young Children Treated for Cancer.
Cancer Res Treat. 2016 Apr; 48(2):658-67.CR

Abstract

PURPOSE

The aim of this study was to compare the incidence of dental complications in childhood cancer survivors with that of healthy control subjects, and to determine the possible influence of various factors associated with patient and treatment.

MATERIALS AND METHODS

Sixty-one panoramic radiographs of the dentition of cancer survivors were compared with 521 radiographs of healthy patients at a similar age, between 5 and 18 years. The mean period from termination of therapy was 4.9 years (58.9 ± 34.3 months), and 51 children (83.60%) were under age 5 when therapy began.

RESULTS

Dental anomalies were found in 38 cancer survivors (62.29%) and 69 control subjects (13.24%) (p < 0.001). Agenesis of teeth was found in 19 cancer patients (31.14%) and in 48 control subjects (9.21%). Microdontic teeth were found in 22 cancer survivors (36.06%) and 15 control subjects (2.87%) (p < 0.001), whereas teeth with short roots were found in seven cancer patients (11.47%) and 15 control subjects (2.87%) (p < 0.01). Dental anomalies in cancer patients were more common in some tooth groups and were not observed in others. The frequency of dental anomalies did not show correlation with age at the beginning or termination or time of therapy.

CONCLUSION

Children under the age of 5 are in a high risk group for dental complications after anticancer treatment. Rudimentary chemotherapy has a considerable impact on the occurrence of dental anomalies.

Authors+Show Affiliations

Department of Pediatric Dentistry, Oncology, Hematology and Diabetology, Medical University of Łódź, Łódź, Poland.Department of Pediatric Dentistry, Oncology, Hematology and Diabetology, Medical University of Łódź, Łódź, Poland.Department of Orthodontics, Oncology, Hematology and Diabetology, Medical University of Łódź, Łódź, Poland.Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Łódź, Łódź, Poland.Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Łódź, Łódź, Poland.Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Łódź, Łódź, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26511809

Citation

Proc, Patrycja, et al. "Dental Anomalies as Late Adverse Effect Among Young Children Treated for Cancer." Cancer Research and Treatment : Official Journal of Korean Cancer Association, vol. 48, no. 2, 2016, pp. 658-67.
Proc P, Szczepańska J, Skiba A, et al. Dental Anomalies as Late Adverse Effect among Young Children Treated for Cancer. Cancer Res Treat. 2016;48(2):658-67.
Proc, P., Szczepańska, J., Skiba, A., Zubowska, M., Fendler, W., & Młynarski, W. (2016). Dental Anomalies as Late Adverse Effect among Young Children Treated for Cancer. Cancer Research and Treatment : Official Journal of Korean Cancer Association, 48(2), 658-67. https://doi.org/10.4143/crt.2015.193
Proc P, et al. Dental Anomalies as Late Adverse Effect Among Young Children Treated for Cancer. Cancer Res Treat. 2016;48(2):658-67. PubMed PMID: 26511809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dental Anomalies as Late Adverse Effect among Young Children Treated for Cancer. AU - Proc,Patrycja, AU - Szczepańska,Joanna, AU - Skiba,Adam, AU - Zubowska,Małgorzata, AU - Fendler,Wojciech, AU - Młynarski,Wojciech, Y1 - 2015/10/14/ PY - 2015/06/03/received PY - 2015/09/10/accepted PY - 2015/10/30/entrez PY - 2015/10/30/pubmed PY - 2018/3/9/medline KW - Child KW - Neoplasms KW - Tooth abnormalities SP - 658 EP - 67 JF - Cancer research and treatment : official journal of Korean Cancer Association JO - Cancer Res Treat VL - 48 IS - 2 N2 - PURPOSE: The aim of this study was to compare the incidence of dental complications in childhood cancer survivors with that of healthy control subjects, and to determine the possible influence of various factors associated with patient and treatment. MATERIALS AND METHODS: Sixty-one panoramic radiographs of the dentition of cancer survivors were compared with 521 radiographs of healthy patients at a similar age, between 5 and 18 years. The mean period from termination of therapy was 4.9 years (58.9 ± 34.3 months), and 51 children (83.60%) were under age 5 when therapy began. RESULTS: Dental anomalies were found in 38 cancer survivors (62.29%) and 69 control subjects (13.24%) (p < 0.001). Agenesis of teeth was found in 19 cancer patients (31.14%) and in 48 control subjects (9.21%). Microdontic teeth were found in 22 cancer survivors (36.06%) and 15 control subjects (2.87%) (p < 0.001), whereas teeth with short roots were found in seven cancer patients (11.47%) and 15 control subjects (2.87%) (p < 0.01). Dental anomalies in cancer patients were more common in some tooth groups and were not observed in others. The frequency of dental anomalies did not show correlation with age at the beginning or termination or time of therapy. CONCLUSION: Children under the age of 5 are in a high risk group for dental complications after anticancer treatment. Rudimentary chemotherapy has a considerable impact on the occurrence of dental anomalies. SN - 2005-9256 UR - https://www.unboundmedicine.com/medline/citation/26511809/Dental_Anomalies_as_Late_Adverse_Effect_among_Young_Children_Treated_for_Cancer_ L2 - https://dx.doi.org/10.4143/crt.2015.193 DB - PRIME DP - Unbound Medicine ER -