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Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the main cause of liver disease worldwide. NAFLD is linked to circumstances such as type 2 diabetes, insulin resistance, obesity, hyperlipidemia, and hypertension. Since the obesity figures and related comorbidities are increasing, NAFLD has turned into a liver problem that has become progressively more common. Currently, there is no effective drug therapy for NAFLD; therefore, interventions in lifestyles remain the first line of treatment. Bearing in mind that adherence rates to this type of treatment are poor, great efforts are currently focused on finding novel therapeutic agents for the prevention in the development of hepatic steatosis and its progression to nonalcoholic steatohepatitis and cirrhosis. This review presents a compilation of the scientific evidence found in the last years showing the results of interventions in lifestyle, diet, and behavioral therapies and research results in human, animal and cell models. Possible therapeutic agents ranging from supplementation with vitamins, amino acids, prebiotics, probiotics, symbiotics, polyunsaturated fatty acids and polyphenols to interventions with medicinal plants are analyzed.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile. cata.hernandezr@gmail.com.

    ,

    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile. rvalenzuelab@med.uchile.cl.

    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 8380453, Chile. lvidela@med.uchile.cl.

    Source

    International journal of molecular sciences 16:10 2015 Oct 23 pg 25168-98

    MeSH

    Animals
    Diet
    Humans
    Life Style
    Non-alcoholic Fatty Liver Disease
    Prebiotics

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26512643

    Citation

    Hernandez-Rodas, Maria Catalina, et al. "Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease." International Journal of Molecular Sciences, vol. 16, no. 10, 2015, pp. 25168-98.
    Hernandez-Rodas MC, Valenzuela R, Videla LA. Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease. Int J Mol Sci. 2015;16(10):25168-98.
    Hernandez-Rodas, M. C., Valenzuela, R., & Videla, L. A. (2015). Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease. International Journal of Molecular Sciences, 16(10), pp. 25168-98. doi:10.3390/ijms161025168.
    Hernandez-Rodas MC, Valenzuela R, Videla LA. Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease. Int J Mol Sci. 2015 Oct 23;16(10):25168-98. PubMed PMID: 26512643.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease. AU - Hernandez-Rodas,Maria Catalina, AU - Valenzuela,Rodrigo, AU - Videla,Luis A, Y1 - 2015/10/23/ PY - 2015/09/09/received PY - 2015/09/29/revised PY - 2015/10/14/accepted PY - 2015/10/30/entrez PY - 2015/10/30/pubmed PY - 2016/8/20/medline KW - NAFLD KW - amino acids KW - diet KW - exercise KW - lifestyle KW - medicinal plants KW - polyphenols KW - polyunsaturated fatty acids KW - prebiotics KW - vitamins SP - 25168 EP - 98 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 16 IS - 10 N2 - Non-alcoholic fatty liver disease (NAFLD) is the main cause of liver disease worldwide. NAFLD is linked to circumstances such as type 2 diabetes, insulin resistance, obesity, hyperlipidemia, and hypertension. Since the obesity figures and related comorbidities are increasing, NAFLD has turned into a liver problem that has become progressively more common. Currently, there is no effective drug therapy for NAFLD; therefore, interventions in lifestyles remain the first line of treatment. Bearing in mind that adherence rates to this type of treatment are poor, great efforts are currently focused on finding novel therapeutic agents for the prevention in the development of hepatic steatosis and its progression to nonalcoholic steatohepatitis and cirrhosis. This review presents a compilation of the scientific evidence found in the last years showing the results of interventions in lifestyle, diet, and behavioral therapies and research results in human, animal and cell models. Possible therapeutic agents ranging from supplementation with vitamins, amino acids, prebiotics, probiotics, symbiotics, polyunsaturated fatty acids and polyphenols to interventions with medicinal plants are analyzed. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/26512643/Relevant_Aspects_of_Nutritional_and_Dietary_Interventions_in_Non_Alcoholic_Fatty_Liver_Disease_ L2 - http://www.mdpi.com/resolver?pii=ijms161025168 DB - PRIME DP - Unbound Medicine ER -