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The correlation of plasma omentin-1 with insulin resistance in non-obese polycystic ovary syndrome.
Ann Endocrinol (Paris). 2015 Oct; 76(5):620-7.AE

Abstract

OBJECTIVES

Aberrant circulating adipokines are considered to be related to the pathological mechanism of polycystic ovary syndrome (PCOS). This study aims to evaluate the relationship between plasma omentin-1 levels, metabolic and hormonal parameters in the setting of non-obese Chinese women with PCOS.

MATERIAL AND METHODS

This was a case-controlled, cross-sectional study of 153 non-obese (BMI<25kg/m(2)) PCOS and 114 age-matched healthy non-obese control individuals. Levels of plasma omentin-1, fasting blood glucose, insulin and sexual hormones and ovary volume were analyzed in all subjects.

RESULTS

Plasma omentin-1 levels of non-obese PCOS individuals were significantly lower than in healthy non-obese controls. Body Mass Index (BMI), homeostasis model of assessment for insulin resistance index (HOMA-IR), levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), LH/FSH ratio and ovary volume (OV) were significantly higher in subjects with PCOS than controls. In the HOMA-IR stratified subgroups, PCOS individuals with insulin resistance had lower omentin-1 than those without insulin resistance after BMI adjustment. Omentin-1 was negatively correlated with BMI, HOMA-IR and fasting insulin. Multiple linear regressions revealed that BMI contributed to omentin-1 levels. Ovary volume was negatively correlated to HOMA-IR but had no correlation with omentin-1.

CONCLUSIONS

Plasma omentin-1 concentrations were decreased in the non-obese PCOS group. Insulin resistance could further decrease plasma omentin-1 in non-obese individuals with PCOS independent of BMI status.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Yang HY
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
Ma Y
Department of Ultrasonic Diagnosis, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Lu XH
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
Liang XH
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
Suo YJ
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
Huang ZX
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
Lu DC
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
Qin YF
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
Luo ZJ
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China. Electronic address: zluo888@163.com.

MeSH

AdolescentAdultBlood GlucoseBody Mass IndexBody WeightCase-Control StudiesChinaCross-Sectional StudiesCytokinesFastingFemaleFollicle Stimulating HormoneGPI-Linked ProteinsHumansInsulinInsulin ResistanceLectinsLuteinizing HormoneObesityOvaryPolycystic Ovary SyndromeTestosteroneYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26514948

Citation

Yang, Hai-Yan, et al. "The Correlation of Plasma Omentin-1 With Insulin Resistance in Non-obese Polycystic Ovary Syndrome." Annales D'endocrinologie, vol. 76, no. 5, 2015, pp. 620-7.
Yang HY, Ma Y, Lu XH, et al. The correlation of plasma omentin-1 with insulin resistance in non-obese polycystic ovary syndrome. Ann Endocrinol (Paris). 2015;76(5):620-7.
Yang, H. Y., Ma, Y., Lu, X. H., Liang, X. H., Suo, Y. J., Huang, Z. X., Lu, D. C., Qin, Y. F., & Luo, Z. J. (2015). The correlation of plasma omentin-1 with insulin resistance in non-obese polycystic ovary syndrome. Annales D'endocrinologie, 76(5), 620-7. https://doi.org/10.1016/j.ando.2015.08.002
Yang HY, et al. The Correlation of Plasma Omentin-1 With Insulin Resistance in Non-obese Polycystic Ovary Syndrome. Ann Endocrinol (Paris). 2015;76(5):620-7. PubMed PMID: 26514948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The correlation of plasma omentin-1 with insulin resistance in non-obese polycystic ovary syndrome. AU - Yang,Hai-Yan, AU - Ma,Yan, AU - Lu,Xin-Hong, AU - Liang,Xing-Huan, AU - Suo,Ying-Jun, AU - Huang,Zhen-Xing, AU - Lu,De-Cheng, AU - Qin,Ying-Fen, AU - Luo,Zuo-Jie, Y1 - 2015/10/26/ PY - 2015/03/16/received PY - 2015/08/03/revised PY - 2015/08/04/accepted PY - 2015/10/31/entrez PY - 2015/10/31/pubmed PY - 2016/8/24/medline KW - BMI KW - IMC KW - Omentin-1 KW - Omentine-1 KW - PCOS KW - SOPK SP - 620 EP - 7 JF - Annales d'endocrinologie JO - Ann Endocrinol (Paris) VL - 76 IS - 5 N2 - OBJECTIVES: Aberrant circulating adipokines are considered to be related to the pathological mechanism of polycystic ovary syndrome (PCOS). This study aims to evaluate the relationship between plasma omentin-1 levels, metabolic and hormonal parameters in the setting of non-obese Chinese women with PCOS. MATERIAL AND METHODS: This was a case-controlled, cross-sectional study of 153 non-obese (BMI<25kg/m(2)) PCOS and 114 age-matched healthy non-obese control individuals. Levels of plasma omentin-1, fasting blood glucose, insulin and sexual hormones and ovary volume were analyzed in all subjects. RESULTS: Plasma omentin-1 levels of non-obese PCOS individuals were significantly lower than in healthy non-obese controls. Body Mass Index (BMI), homeostasis model of assessment for insulin resistance index (HOMA-IR), levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), LH/FSH ratio and ovary volume (OV) were significantly higher in subjects with PCOS than controls. In the HOMA-IR stratified subgroups, PCOS individuals with insulin resistance had lower omentin-1 than those without insulin resistance after BMI adjustment. Omentin-1 was negatively correlated with BMI, HOMA-IR and fasting insulin. Multiple linear regressions revealed that BMI contributed to omentin-1 levels. Ovary volume was negatively correlated to HOMA-IR but had no correlation with omentin-1. CONCLUSIONS: Plasma omentin-1 concentrations were decreased in the non-obese PCOS group. Insulin resistance could further decrease plasma omentin-1 in non-obese individuals with PCOS independent of BMI status. SN - 2213-3941 UR - https://www.unboundmedicine.com/medline/citation/26514948/The_correlation_of_plasma_omentin_1_with_insulin_resistance_in_non_obese_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -