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Dietary fat and fatty acid intake and epithelial ovarian cancer risk: evidence from epidemiological studies.
Oncotarget. 2015 Dec 15; 6(40):43099-119.O

Abstract

The associations between dietary fat and fatty acid (FA) intakes and epithelial ovarian cancer (EOC) risk have been inconsistent in previous studies. We conducted a meta-analysis of epidemiological studies to evaluate these associations. We identified relevant studies by searching PubMed, EMBASE, and Web of Science databases. We used random-effects models to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Overall, the search yielded 20 studies (1 pooled analysis of 12 cohort studies, 5 cohorts, and 14 case-control studies). The summary RR for EOC for the highest versus lowest categories of total dietary fat intake was 1.12 (95%CI= 0.95-1.33; I2 = 77.4%; n = 14). The RRs were not significant when fats were divided into plant-based fats (RR = 0.93, 95%CI = 0.77-1.13; n = 6), animal-based fats (RR = 1.15, 95%CI = 0.95-1.39; n = 8), dairy-based fats (RR = 1.02, 95%CI = 0.88-1.18; n = 3), saturated FAs (RR = 1.04, 95%CI = 0.93-1.17; n = 12), monounsaturated FAs (RR = 0.98, 95%CI = 0.84-1.13; n = 10), polyunsaturated FAs (RR = 0.96, 95%CI = 0.81-1.12; n = 10), and trans-unsaturated FAs (RR = 1.15, 95%CI = 0.98-1.36; n = 3). Similar non-significant results were also observed in most of the subgroup and sensitivity analyses. The findings of this meta-analysis suggest a lack of evidence for associations between dietary fat and FA intakes and EOC risk. Further analyses should be conducted to assess the associations with other types of fat, and the results should be stratified by tumor invasiveness and EOC histology.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

26515595

Citation

Hou, Rui, et al. "Dietary Fat and Fatty Acid Intake and Epithelial Ovarian Cancer Risk: Evidence From Epidemiological Studies." Oncotarget, vol. 6, no. 40, 2015, pp. 43099-119.
Hou R, Wu QJ, Gong TT, et al. Dietary fat and fatty acid intake and epithelial ovarian cancer risk: evidence from epidemiological studies. Oncotarget. 2015;6(40):43099-119.
Hou, R., Wu, Q. J., Gong, T. T., & Jiang, L. (2015). Dietary fat and fatty acid intake and epithelial ovarian cancer risk: evidence from epidemiological studies. Oncotarget, 6(40), 43099-119. https://doi.org/10.18632/oncotarget.5525
Hou R, et al. Dietary Fat and Fatty Acid Intake and Epithelial Ovarian Cancer Risk: Evidence From Epidemiological Studies. Oncotarget. 2015 Dec 15;6(40):43099-119. PubMed PMID: 26515595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat and fatty acid intake and epithelial ovarian cancer risk: evidence from epidemiological studies. AU - Hou,Rui, AU - Wu,Qi-Jun, AU - Gong,Ting-Ting, AU - Jiang,Luo, PY - 2015/07/14/received PY - 2015/10/16/accepted PY - 2015/10/31/entrez PY - 2015/10/31/pubmed PY - 2016/10/8/medline KW - diet KW - fat KW - fatty acid KW - meta-analysis KW - ovarian cancer SP - 43099 EP - 119 JF - Oncotarget JO - Oncotarget VL - 6 IS - 40 N2 - The associations between dietary fat and fatty acid (FA) intakes and epithelial ovarian cancer (EOC) risk have been inconsistent in previous studies. We conducted a meta-analysis of epidemiological studies to evaluate these associations. We identified relevant studies by searching PubMed, EMBASE, and Web of Science databases. We used random-effects models to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Overall, the search yielded 20 studies (1 pooled analysis of 12 cohort studies, 5 cohorts, and 14 case-control studies). The summary RR for EOC for the highest versus lowest categories of total dietary fat intake was 1.12 (95%CI= 0.95-1.33; I2 = 77.4%; n = 14). The RRs were not significant when fats were divided into plant-based fats (RR = 0.93, 95%CI = 0.77-1.13; n = 6), animal-based fats (RR = 1.15, 95%CI = 0.95-1.39; n = 8), dairy-based fats (RR = 1.02, 95%CI = 0.88-1.18; n = 3), saturated FAs (RR = 1.04, 95%CI = 0.93-1.17; n = 12), monounsaturated FAs (RR = 0.98, 95%CI = 0.84-1.13; n = 10), polyunsaturated FAs (RR = 0.96, 95%CI = 0.81-1.12; n = 10), and trans-unsaturated FAs (RR = 1.15, 95%CI = 0.98-1.36; n = 3). Similar non-significant results were also observed in most of the subgroup and sensitivity analyses. The findings of this meta-analysis suggest a lack of evidence for associations between dietary fat and FA intakes and EOC risk. Further analyses should be conducted to assess the associations with other types of fat, and the results should be stratified by tumor invasiveness and EOC histology. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/26515595/Dietary_fat_and_fatty_acid_intake_and_epithelial_ovarian_cancer_risk:_evidence_from_epidemiological_studies_ L2 - http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=5525 DB - PRIME DP - Unbound Medicine ER -