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Immune-mediated statin myopathy.
Expert Rev Clin Immunol. 2016; 12(1):33-8.ER

Abstract

Statin-induced necrotizing autoimmune myopathy (SINAM) is associated with a unique clinical 5 phenotype of severe proximal muscle weakness during or after exposure to statins in patients with high creatine kinase (CK) levels. Electromyography (EMG) and muscle biopsy reveal features of a necrotizing myopathy and the anti-HMGCR autoantibody is frequently detected. Treatment requires a combination of statin discontinuation as well as immunomodulatory or immunosuppressive therapy. HLA typing (HLADRB1*1101) is strongly associated with anti-10 HMGCR autoantibody positivity in statin-exposed patients. It is well documented that statin triggers autoimmune disease in those with a genetic susceptibility. With the commercial availability of an accurate ELISA test, the natural history of the disease and its phenotypic features are becoming increasingly understood.

Authors+Show Affiliations

a Division of Rheumatology and Clinical Immunology, Department of Medicine , University of Pittsburgh , Pittsburgh , PA , USA.a Division of Rheumatology and Clinical Immunology, Department of Medicine , University of Pittsburgh , Pittsburgh , PA , USA.a Division of Rheumatology and Clinical Immunology, Department of Medicine , University of Pittsburgh , Pittsburgh , PA , USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26515829

Citation

Loganathan, Priyadarshini, et al. "Immune-mediated Statin Myopathy." Expert Review of Clinical Immunology, vol. 12, no. 1, 2016, pp. 33-8.
Loganathan P, Oddis CV, Aggarwal R. Immune-mediated statin myopathy. Expert Rev Clin Immunol. 2016;12(1):33-8.
Loganathan, P., Oddis, C. V., & Aggarwal, R. (2016). Immune-mediated statin myopathy. Expert Review of Clinical Immunology, 12(1), 33-8. https://doi.org/10.1586/1744666X.2016.1103181
Loganathan P, Oddis CV, Aggarwal R. Immune-mediated Statin Myopathy. Expert Rev Clin Immunol. 2016;12(1):33-8. PubMed PMID: 26515829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune-mediated statin myopathy. AU - Loganathan,Priyadarshini, AU - Oddis,Chester V, AU - Aggarwal,Rohit, Y1 - 2015/10/30/ PY - 2015/10/31/entrez PY - 2015/10/31/pubmed PY - 2016/8/30/medline KW - anti HMGCR antibody KW - autoimmune KW - hydroxy-methyl-glutaryl-Co-A reductase KW - necrotizing myopathy KW - statin SP - 33 EP - 8 JF - Expert review of clinical immunology JO - Expert Rev Clin Immunol VL - 12 IS - 1 N2 - Statin-induced necrotizing autoimmune myopathy (SINAM) is associated with a unique clinical 5 phenotype of severe proximal muscle weakness during or after exposure to statins in patients with high creatine kinase (CK) levels. Electromyography (EMG) and muscle biopsy reveal features of a necrotizing myopathy and the anti-HMGCR autoantibody is frequently detected. Treatment requires a combination of statin discontinuation as well as immunomodulatory or immunosuppressive therapy. HLA typing (HLADRB1*1101) is strongly associated with anti-10 HMGCR autoantibody positivity in statin-exposed patients. It is well documented that statin triggers autoimmune disease in those with a genetic susceptibility. With the commercial availability of an accurate ELISA test, the natural history of the disease and its phenotypic features are becoming increasingly understood. SN - 1744-8409 UR - https://www.unboundmedicine.com/medline/citation/26515829/Immune_mediated_statin_myopathy_ L2 - https://www.tandfonline.com/doi/full/10.1586/1744666X.2016.1103181 DB - PRIME DP - Unbound Medicine ER -