Tags

Type your tag names separated by a space and hit enter

Temporal change in prevalence and complications of uveitis associated with juvenile idiopathic arthritis:data from a cross-sectional analysis of a prospective nationwide study.
Clin Exp Rheumatol. 2015 Nov-Dec; 33(6):936-44.CE

Abstract

OBJECTIVES

To analyse the nationwide prevalence of uveitis in JIA and its complications over a whole decade.

METHODS

We conducted a prospective, observational and cross-sectional study including all JIA patients from a National Paediatric Rheumatological Database (NPRD) with a uveitis add-on module in Germany (2002-2013). Temporal changes in uveitis prevalence, related secondary complications and anti-inflammatory medication were evaluated.

RESULTS

A total of 60 centres including 18,555 JIA patients (mean 3,863 patients/year, SD=837) were documented in the NPRD between 2002 and 2013. The mean age of the patients was 11.4 ± 4.6 years, their mean disease duration 4.4 ± 3.7 years. Among them, 66.9% were female and 51.7% ANA positive. Patients' mean age at arthritis onset was 6.9 ± 4.5 years. Treatment rates with synthetic and biological DMARDs increased during the observation period (sDMARD: 39.8% to 47.2%, bDMARD: 3.3% to 21.8%). Uveitis prevalence decreased significantly from 2002 to 2013 (13.0% to 11.6%, OR = 0.98, p=0.015). The prevalence of secondary uveitis complications also decreased significantly between 2002 and 2013 (33.6% to 23.9%, OR=0.94, p<0.001). Among the complications, the most common ones were posterior synechiae, cataract and band keratopathy. A significant increase in achieving uveitis inactivity was observed at 30.6% in 2002 and 65.3% in 2013 (OR=1.15, p<0.001).

CONCLUSIONS

Uveitis prevalence and complications significantly decreased between 2002 and 2013. This may be associated with a more frequent use of DMARDs.

Authors+Show Affiliations

Tappeiner C
German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin; Department of Ophthalmology at St. Franziskus Hospital, Muenster, Germany; Department of Ophthalmology, Inselspital, University of Bern, Switzerland.
Klotsche J
German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin; and Charité Universitätsmedizin Berlin, Institute for Social Medicine, Epidemiology and Health Economics, Berlin, Germany.
Schenck S
German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin, Germany.
Niewerth M
German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin, Germany.
Minden K
German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin; and Charité Universitätsmedizin Berlin, Children's University Hospital, Berlin, Germany.
Heiligenhaus A
Department of Ophthalmology at St. Franziskus Hospital, Münster; and University Duisburg-Essen, Germany.

MeSH

AdolescentAge of OnsetAntirheumatic AgentsArthritis, JuvenileChildCross-Sectional StudiesDatabases, FactualFemaleGermanyHumansMalePrevalenceProspective StudiesRisk FactorsTime FactorsUveitis

Pub Type(s)

Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26517055

Citation

Tappeiner, C, et al. "Temporal Change in Prevalence and Complications of Uveitis Associated With Juvenile Idiopathic Arthritis:data From a Cross-sectional Analysis of a Prospective Nationwide Study." Clinical and Experimental Rheumatology, vol. 33, no. 6, 2015, pp. 936-44.
Tappeiner C, Klotsche J, Schenck S, et al. Temporal change in prevalence and complications of uveitis associated with juvenile idiopathic arthritis:data from a cross-sectional analysis of a prospective nationwide study. Clin Exp Rheumatol. 2015;33(6):936-44.
Tappeiner, C., Klotsche, J., Schenck, S., Niewerth, M., Minden, K., & Heiligenhaus, A. (2015). Temporal change in prevalence and complications of uveitis associated with juvenile idiopathic arthritis:data from a cross-sectional analysis of a prospective nationwide study. Clinical and Experimental Rheumatology, 33(6), 936-44.
Tappeiner C, et al. Temporal Change in Prevalence and Complications of Uveitis Associated With Juvenile Idiopathic Arthritis:data From a Cross-sectional Analysis of a Prospective Nationwide Study. Clin Exp Rheumatol. 2015 Nov-Dec;33(6):936-44. PubMed PMID: 26517055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temporal change in prevalence and complications of uveitis associated with juvenile idiopathic arthritis:data from a cross-sectional analysis of a prospective nationwide study. AU - Tappeiner,C, AU - Klotsche,J, AU - Schenck,S, AU - Niewerth,M, AU - Minden,K, AU - Heiligenhaus,A, Y1 - 2015/10/30/ PY - 2015/05/03/received PY - 2015/07/23/accepted PY - 2015/10/31/entrez PY - 2015/10/31/pubmed PY - 2016/3/25/medline SP - 936 EP - 44 JF - Clinical and experimental rheumatology JO - Clin Exp Rheumatol VL - 33 IS - 6 N2 - OBJECTIVES: To analyse the nationwide prevalence of uveitis in JIA and its complications over a whole decade. METHODS: We conducted a prospective, observational and cross-sectional study including all JIA patients from a National Paediatric Rheumatological Database (NPRD) with a uveitis add-on module in Germany (2002-2013). Temporal changes in uveitis prevalence, related secondary complications and anti-inflammatory medication were evaluated. RESULTS: A total of 60 centres including 18,555 JIA patients (mean 3,863 patients/year, SD=837) were documented in the NPRD between 2002 and 2013. The mean age of the patients was 11.4 ± 4.6 years, their mean disease duration 4.4 ± 3.7 years. Among them, 66.9% were female and 51.7% ANA positive. Patients' mean age at arthritis onset was 6.9 ± 4.5 years. Treatment rates with synthetic and biological DMARDs increased during the observation period (sDMARD: 39.8% to 47.2%, bDMARD: 3.3% to 21.8%). Uveitis prevalence decreased significantly from 2002 to 2013 (13.0% to 11.6%, OR = 0.98, p=0.015). The prevalence of secondary uveitis complications also decreased significantly between 2002 and 2013 (33.6% to 23.9%, OR=0.94, p<0.001). Among the complications, the most common ones were posterior synechiae, cataract and band keratopathy. A significant increase in achieving uveitis inactivity was observed at 30.6% in 2002 and 65.3% in 2013 (OR=1.15, p<0.001). CONCLUSIONS: Uveitis prevalence and complications significantly decreased between 2002 and 2013. This may be associated with a more frequent use of DMARDs. SN - 0392-856X UR - https://www.unboundmedicine.com/medline/citation/26517055/Temporal_change_in_prevalence_and_complications_of_uveitis_associated_with_juvenile_idiopathic_arthritis:data_from_a_cross_sectional_analysis_of_a_prospective_nationwide_study_ DB - PRIME DP - Unbound Medicine ER -