Tags

Type your tag names separated by a space and hit enter

Magnetic resonance correlation of iron content with neuromelanin in the substantia nigra of early-stage Parkinson's disease.
Eur J Neurol. 2016 Feb; 23(2):368-74.EJ

Abstract

BACKGROUND AND PURPOSE

Magnetic resonance (MR) studies have demonstrated a significant reduction of neuromelanin in the substantia nigra (SN) of Parkinson's disease (PD) patients with high accuracy for differential diagnosis compared to non-PD controls and essential tremor. However, studies state that not knowing how paramagnetic effects of iron influence neuromelanin signal is a limitation. In this study a neuromelanin-sensitive MR sequence was combined with T2* relaxometry iron quantification analysis to study the SN of early-stage PD patients to investigate the correlation between these parameters.

METHODS

The inclusion criteria were untreated de novo PD patients and a 2-5 year disease duration (early PD); in addition, age-matched controls were enrolled. These were studied at 3.0 T with a high-resolution T1-weighted MR sequence to visualize neuromelanin and a relaxometry sequence for iron quantification. The primary outcome was the correlation of the width of the neuromelanin high signal region and the T2* values in the lateral, central and medial segments of the SN.

RESULTS

Very weak correlations of T2* values with neuromelanin width, positive for global and negative for the medial and lateral SN segments, were found in both PD groups and control subjects. The SN neuromelanin width was markedly reduced in the de novo and early PD groups compared with controls in all SN segments, but no significant difference in T2* values was found between the groups.

CONCLUSIONS

The SN neuromelanin signal does not have a significant correlation with iron content in PD patients or controls. The neuromelanin MR signal reduction in PD does not seem to be significantly influenced by paramagnetic iron effects.

Authors+Show Affiliations

Neurological Imaging Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Lisbon, Portugal. Clinical Pharmacology Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal.Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal.Clinical Pharmacology Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal. Neurology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Lisbon, Portugal. CNS - Campus Neurológico Sénior, Torres Vedras, Portugal.Clinical Pharmacology Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal. Neurology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Lisbon, Portugal.Clinical Pharmacology Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.Clinical Pharmacology Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.Neurological Imaging Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Lisbon, Portugal.Clinical Pharmacology Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal. Neurology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Lisbon, Portugal. CNS - Campus Neurológico Sénior, Torres Vedras, Portugal. Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26518135

Citation

Reimão, S, et al. "Magnetic Resonance Correlation of Iron Content With Neuromelanin in the Substantia Nigra of Early-stage Parkinson's Disease." European Journal of Neurology, vol. 23, no. 2, 2016, pp. 368-74.
Reimão S, Ferreira S, Nunes RG, et al. Magnetic resonance correlation of iron content with neuromelanin in the substantia nigra of early-stage Parkinson's disease. Eur J Neurol. 2016;23(2):368-74.
Reimão, S., Ferreira, S., Nunes, R. G., Pita Lobo, P., Neutel, D., Abreu, D., Gonçalves, N., Campos, J., & Ferreira, J. J. (2016). Magnetic resonance correlation of iron content with neuromelanin in the substantia nigra of early-stage Parkinson's disease. European Journal of Neurology, 23(2), 368-74. https://doi.org/10.1111/ene.12838
Reimão S, et al. Magnetic Resonance Correlation of Iron Content With Neuromelanin in the Substantia Nigra of Early-stage Parkinson's Disease. Eur J Neurol. 2016;23(2):368-74. PubMed PMID: 26518135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic resonance correlation of iron content with neuromelanin in the substantia nigra of early-stage Parkinson's disease. AU - Reimão,S, AU - Ferreira,S, AU - Nunes,R G, AU - Pita Lobo,P, AU - Neutel,D, AU - Abreu,D, AU - Gonçalves,N, AU - Campos,J, AU - Ferreira,J J, Y1 - 2015/10/31/ PY - 2015/02/28/received PY - 2015/08/04/accepted PY - 2015/11/1/entrez PY - 2015/11/1/pubmed PY - 2016/9/28/medline KW - MRI KW - Parkinson's disease KW - iron KW - neuromelanin KW - substantia nigra SP - 368 EP - 74 JF - European journal of neurology JO - Eur J Neurol VL - 23 IS - 2 N2 - BACKGROUND AND PURPOSE: Magnetic resonance (MR) studies have demonstrated a significant reduction of neuromelanin in the substantia nigra (SN) of Parkinson's disease (PD) patients with high accuracy for differential diagnosis compared to non-PD controls and essential tremor. However, studies state that not knowing how paramagnetic effects of iron influence neuromelanin signal is a limitation. In this study a neuromelanin-sensitive MR sequence was combined with T2* relaxometry iron quantification analysis to study the SN of early-stage PD patients to investigate the correlation between these parameters. METHODS: The inclusion criteria were untreated de novo PD patients and a 2-5 year disease duration (early PD); in addition, age-matched controls were enrolled. These were studied at 3.0 T with a high-resolution T1-weighted MR sequence to visualize neuromelanin and a relaxometry sequence for iron quantification. The primary outcome was the correlation of the width of the neuromelanin high signal region and the T2* values in the lateral, central and medial segments of the SN. RESULTS: Very weak correlations of T2* values with neuromelanin width, positive for global and negative for the medial and lateral SN segments, were found in both PD groups and control subjects. The SN neuromelanin width was markedly reduced in the de novo and early PD groups compared with controls in all SN segments, but no significant difference in T2* values was found between the groups. CONCLUSIONS: The SN neuromelanin signal does not have a significant correlation with iron content in PD patients or controls. The neuromelanin MR signal reduction in PD does not seem to be significantly influenced by paramagnetic iron effects. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/26518135/Magnetic_resonance_correlation_of_iron_content_with_neuromelanin_in_the_substantia_nigra_of_early_stage_Parkinson's_disease_ L2 - https://doi.org/10.1111/ene.12838 DB - PRIME DP - Unbound Medicine ER -