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W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway.
Tumour Biol. 2016 Apr; 37(4):4791-801.TB

Abstract

The therapeutic agent selectively killing cancer cells is urgently needed for gastric cancer treatment. Curcumin has been investigated for its effect on the cancer treatment because of its significant therapeutic potential and safety profile. A synthetic unsymmetry mono-carbonyl compound termed W346 was developed from curcumin. In this study, we investigated the potential antineoplastic effect and mechanism of W346 against human gastric cancer cells. W346 suppressed the proliferation and invasion, blocked cell cycle arrest at G2/M phase, and increased apoptosis in gastric cancer cells, and it presented obviously improved anticancer activity than curcumin. Moreover, W346 effectively inhibited tumor necrosis factor (TNF-α)-induced NF-κB activation by suppressing IKK phosphorylation, inhibiting IκB-α degradation, and restraining the accumulation of NF-κB subunit p65 nuclear translocation. W346 also affected NF-κB-regulated downstream products involved in cycle arrest and apoptosis. In a word, W346 exhibited significantly improved anti-gastric cancer activity over curcumin by targeting NF-κB signaling pathway, and it is likely to be a promising starting point for the development of curcumin-based therapeutic agent.

Authors+Show Affiliations

Department of Digestive Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. Pharmacy Department, Tonglu First People's Hospital, Hangzhou, Zhejiang, 311500, China.Institute of Sports Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.Department of Digestive Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.Department of General Surgery, The fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.Department of Digestive Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.Department of Digestive Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.Department of Digestive Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. jinrongjrjr@163.com. Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. jinrongjrjr@163.com.Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. wjzwzmu@163.com.Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26520440

Citation

Xia, Yiqun, et al. "W346 Inhibits Cell Growth, Invasion, Induces Cycle Arrest and Potentiates Apoptosis in Human Gastric Cancer Cells in Vitro Through the NF-κB Signaling Pathway." Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, vol. 37, no. 4, 2016, pp. 4791-801.
Xia Y, Weng B, Wang Z, et al. W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway. Tumour Biol. 2016;37(4):4791-801.
Xia, Y., Weng, B., Wang, Z., Kang, Y., Shi, L., Huang, G., Ying, S., Du, X., Chen, Q., Jin, R., Wu, J., & Liang, G. (2016). W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway. Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 37(4), 4791-801. https://doi.org/10.1007/s13277-015-4277-2
Xia Y, et al. W346 Inhibits Cell Growth, Invasion, Induces Cycle Arrest and Potentiates Apoptosis in Human Gastric Cancer Cells in Vitro Through the NF-κB Signaling Pathway. Tumour Biol. 2016;37(4):4791-801. PubMed PMID: 26520440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway. AU - Xia,Yiqun, AU - Weng,Bixia, AU - Wang,Zhankun, AU - Kang,Yanting, AU - Shi,Lingyi, AU - Huang,Guanqun, AU - Ying,Shilong, AU - Du,Xiaojing, AU - Chen,Qiuxiang, AU - Jin,Rong, AU - Wu,Jianzhang, AU - Liang,Guang, Y1 - 2015/10/31/ PY - 2015/07/26/received PY - 2015/10/19/accepted PY - 2015/11/2/entrez PY - 2015/11/2/pubmed PY - 2017/2/14/medline KW - Anticancer drug KW - Apoptosis KW - Curcumin KW - Gastric cancer KW - NF-κB KW - W346 SP - 4791 EP - 801 JF - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine JO - Tumour Biol VL - 37 IS - 4 N2 - The therapeutic agent selectively killing cancer cells is urgently needed for gastric cancer treatment. Curcumin has been investigated for its effect on the cancer treatment because of its significant therapeutic potential and safety profile. A synthetic unsymmetry mono-carbonyl compound termed W346 was developed from curcumin. In this study, we investigated the potential antineoplastic effect and mechanism of W346 against human gastric cancer cells. W346 suppressed the proliferation and invasion, blocked cell cycle arrest at G2/M phase, and increased apoptosis in gastric cancer cells, and it presented obviously improved anticancer activity than curcumin. Moreover, W346 effectively inhibited tumor necrosis factor (TNF-α)-induced NF-κB activation by suppressing IKK phosphorylation, inhibiting IκB-α degradation, and restraining the accumulation of NF-κB subunit p65 nuclear translocation. W346 also affected NF-κB-regulated downstream products involved in cycle arrest and apoptosis. In a word, W346 exhibited significantly improved anti-gastric cancer activity over curcumin by targeting NF-κB signaling pathway, and it is likely to be a promising starting point for the development of curcumin-based therapeutic agent. SN - 1423-0380 UR - https://www.unboundmedicine.com/medline/citation/26520440/W346_inhibits_cell_growth_invasion_induces_cycle_arrest_and_potentiates_apoptosis_in_human_gastric_cancer_cells_in_vitro_through_the_NF_κB_signaling_pathway_ L2 - https://link.springer.com/article/10.1007/s13277-015-4277-2 DB - PRIME DP - Unbound Medicine ER -