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Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study.
Atherosclerosis. 2015 Dec; 243(2):546-52.A

Abstract

BACKGROUND AND AIMS

Endothelial cell-selective adhesion molecule (ESAM) is selectively expressed on vascular endothelium and is postulated to play a role in atherogenesis. We investigated the association of serum soluble ESAM (sESAM) levels with subsequent cardiovascular outcomes in patients with stable ischemic heart disease.

METHODS

We measured sESAM levels in 981 patients with stable coronary disease enrolled between September 2000 and December 2002 in a prospective cohort study. Poisson regression models were used to define the relationship between baseline sESAM levels and cardiovascular outcomes, including myocardial infarction, heart failure hospitalization, and mortality.

RESULTS

There were 293 occurrences of the composite endpoint over a median follow-up of 8.9 years. After adjusting for demographic and clinical risk factors, participants in the highest sESAM quartile (compared to the lower three sESAM quartiles) had a higher rate of the composite endpoint (incident rate ratio (IRR) 1.52 (95% CI 1.16-1.99) as well as of its individual components: myocardial infarction (IRR 1.64 (1.06-2.55)), heart failure hospitalizations (IRR 1.96 (1.32-2.81)), and death (IRR 1.5 (1.2-1.89)). These associations were no longer significant after adjustment for estimated glomerular filtration rate.

CONCLUSIONS

sESAM levels associate with myocardial infarction, heart failure, and death after adjustment for demographic and clinical risk factors, but not after adjustment for kidney function. sESAM may be involved in the pathogenesis of concurrent kidney and cardiovascular disease.

Authors+Show Affiliations

Division of Nephrology, University of California, San Francisco (UCSF), San Francisco, CA, USA. Electronic address: meyeon.park@ucsf.edu.Kaiser Permanente, McLean, VA, USA.Division of Cardiology, VA Puget Sound Health Care System, University of Washington, USA.Division of Cardiology, VA Puget Sound Health Care System, University of Washington, USA; Division of Cardiology, University of California San Francisco and San Francisco General Hospital, USA.Department of Medicine, San Francisco VA Hospital, San Francisco, CA, USA.Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, USA.Department of Medicine, San Francisco VA Hospital, San Francisco, CA, USA; Department of Medicine, UCSF, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26523992

Citation

Park, Meyeon, et al. "Soluble Endothelial Cell Selective Adhesion Molecule and Cardiovascular Outcomes in Patients With Stable Coronary Disease: a Report From the Heart and Soul Study." Atherosclerosis, vol. 243, no. 2, 2015, pp. 546-52.
Park M, Kulkarni A, Beatty A, et al. Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study. Atherosclerosis. 2015;243(2):546-52.
Park, M., Kulkarni, A., Beatty, A., Ganz, P., Regan, M., Vittinghoff, E., & Whooley, M. (2015). Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study. Atherosclerosis, 243(2), 546-52. https://doi.org/10.1016/j.atherosclerosis.2015.10.092
Park M, et al. Soluble Endothelial Cell Selective Adhesion Molecule and Cardiovascular Outcomes in Patients With Stable Coronary Disease: a Report From the Heart and Soul Study. Atherosclerosis. 2015;243(2):546-52. PubMed PMID: 26523992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study. AU - Park,Meyeon, AU - Kulkarni,Ameya, AU - Beatty,Alexis, AU - Ganz,Peter, AU - Regan,Mathilda, AU - Vittinghoff,Eric, AU - Whooley,Mary, Y1 - 2015/10/24/ PY - 2015/09/11/received PY - 2015/10/08/revised PY - 2015/10/21/accepted PY - 2015/11/3/entrez PY - 2015/11/3/pubmed PY - 2016/9/16/medline KW - Atherosclerosis KW - Cardiovascular mortality KW - Endothelium KW - Kidney disease SP - 546 EP - 52 JF - Atherosclerosis JO - Atherosclerosis VL - 243 IS - 2 N2 - BACKGROUND AND AIMS: Endothelial cell-selective adhesion molecule (ESAM) is selectively expressed on vascular endothelium and is postulated to play a role in atherogenesis. We investigated the association of serum soluble ESAM (sESAM) levels with subsequent cardiovascular outcomes in patients with stable ischemic heart disease. METHODS: We measured sESAM levels in 981 patients with stable coronary disease enrolled between September 2000 and December 2002 in a prospective cohort study. Poisson regression models were used to define the relationship between baseline sESAM levels and cardiovascular outcomes, including myocardial infarction, heart failure hospitalization, and mortality. RESULTS: There were 293 occurrences of the composite endpoint over a median follow-up of 8.9 years. After adjusting for demographic and clinical risk factors, participants in the highest sESAM quartile (compared to the lower three sESAM quartiles) had a higher rate of the composite endpoint (incident rate ratio (IRR) 1.52 (95% CI 1.16-1.99) as well as of its individual components: myocardial infarction (IRR 1.64 (1.06-2.55)), heart failure hospitalizations (IRR 1.96 (1.32-2.81)), and death (IRR 1.5 (1.2-1.89)). These associations were no longer significant after adjustment for estimated glomerular filtration rate. CONCLUSIONS: sESAM levels associate with myocardial infarction, heart failure, and death after adjustment for demographic and clinical risk factors, but not after adjustment for kidney function. sESAM may be involved in the pathogenesis of concurrent kidney and cardiovascular disease. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/26523992/Soluble_endothelial_cell_selective_adhesion_molecule_and_cardiovascular_outcomes_in_patients_with_stable_coronary_disease:_A_report_from_the_Heart_and_Soul_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(15)30176-3 DB - PRIME DP - Unbound Medicine ER -